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19 条记录 (耗时 0.034 秒)

    Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them
    2.
    发明授权
    Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them 失效
    类固醇，它们作为药物的用途，其制备方法，该方法的中间体和含有它们的组合物

    公开(公告)号：US06492536B2

    公开(公告)日：2002-12-10

    申请号：US09891558

    申请日：2001-06-25

    申请人： Neerja Bhatnagar ,  Andre Claussner ,  Christian Marchandeau ,  Michele Resche Rigon ,  Jean-Georges Teutsch

    发明人： Neerja Bhatnagar ,  Andre Claussner ,  Christian Marchandeau ,  Michele Resche Rigon ,  Jean-Georges Teutsch

    IPC分类号： C07J300

    CPC分类号： C07J41/0094 ,  C07J7/0085 ,  C07J9/005 ,  C07J31/006

    摘要： The subject of the invention is the products of formula (I): in which either R1 represents halogen, hydroxyl, (C1-C8) alkyloxy or (C1-C12) acyloxy, and R2 represents halogen or hydrogen, or R1 and R2 form together a double bond, Z is chosen from optionally substituted (C1-C8) alkylthio, optionally substituted arylthio, (C1-C8) alkyloxy, halogen, cyano, mercapto, thiocyanato and (CH2)0-1—CO2H, optionally esterified, Y represents hydrogen or methyl, the dotted line in position 1-2 or 5-6 optionally representing a second bond, as well as their addition salts, their preparation process, the intermediates of this process and the pharmaceutical compositions containing them.

    摘要翻译： 本发明的主题是式（I）的产物：其中R 1表示卤素，羟基，（C 1 -C 8）烷氧基或（C 1 -C 12）酰氧基，R 2表示卤素或氢，或R 1和R 2一起形成 Z选自任选取代的（C 1 -C 8）烷硫基，任选取代的芳硫基，（C 1 -C 8）烷氧基，卤素，氰基，巯基，氰硫基和（CH 2）0-1-CO 2 H，任选酯化，Y代表 氢或甲基，位置1-2或5-6中的虚线任选代表第二个键，以及它们的加成盐，其制备方法，该方法的中间体和含有它们的药物组合物。