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公开(公告)号:US09101687B2
公开(公告)日:2015-08-11
申请号:US13551878
申请日:2012-07-18
申请人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号: C07K14/001 , A61K6/0002 , A61K6/02 , A61K6/08 , A61K8/042 , A61K8/64 , A61K47/42 , A61K47/64 , A61K47/6903 , A61K2800/40 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , A61Q5/00 , A61Q19/00 , C07K7/06 , C12N5/0068 , C12N2533/50
摘要: There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
摘要翻译: 描述了包括带,带,原纤维或纤维的材料,其特征在于,每个条带,原纤维或纤维具有在“带状”子结构中的反向平行布置的肽,其中该材料包括一对自组装互补 多肽。
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公开(公告)号:US08586539B2
公开(公告)日:2013-11-19
申请号:US12729046
申请日:2010-03-22
申请人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号: C07K7/06 , A61K8/64 , A61K47/42 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/52 , A61L27/56 , A61L27/60 , A61L31/047 , A61L31/14 , A61L2400/18 , A61L2430/02 , A61L2430/12 , A61L2430/32 , A61L2430/34 , A61Q5/00 , A61Q11/00 , A61Q19/00 , C09K8/62 , C09K2208/08
摘要: There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a β-sheet tape-like substructure.
摘要翻译: 描述了包括带,带,原纤维或纤维的材料,其特征在于,每个带,原纤维或纤维在β-片带状亚结构中具有肽的反向平行布置。
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公开(公告)号:US20100234304A1
公开(公告)日:2010-09-16
申请号:US12729046
申请日:2010-03-22
申请人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号: C07K7/06 , A61K8/64 , A61K47/42 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/52 , A61L27/56 , A61L27/60 , A61L31/047 , A61L31/14 , A61L2400/18 , A61L2430/02 , A61L2430/12 , A61L2430/32 , A61L2430/34 , A61Q5/00 , A61Q11/00 , A61Q19/00 , C09K8/62 , C09K2208/08
摘要: There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a β-sheet tape-like substructure.
摘要翻译: 描述了包括带,带,原纤维或纤维的材料,其特征在于,每个条带,原纤维或纤维具有在“带状”底层结构中的肽的反向平行布置。
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公开(公告)号:US20130012457A1
公开(公告)日:2013-01-10
申请号:US13551878
申请日:2012-07-18
申请人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号: C07K14/001 , A61K6/0002 , A61K6/02 , A61K6/08 , A61K8/042 , A61K8/64 , A61K47/42 , A61K47/64 , A61K47/6903 , A61K2800/40 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , A61Q5/00 , A61Q19/00 , C07K7/06 , C12N5/0068 , C12N2533/50
摘要: There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
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公开(公告)号:US20060154852A1
公开(公告)日:2006-07-13
申请号:US10521628
申请日:2003-07-15
申请人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人: Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
IPC分类号: A61K38/00
CPC分类号: A61L27/22 , C07K14/001
摘要: There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.
摘要翻译: 描述了包括丝带,原纤维或纤维的材料,其特征在于,每个条带,原纤维或纤维在β-片带状亚结构中具有肽的反向平行布置。
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公开(公告)号:US07700721B2
公开(公告)日:2010-04-20
申请号:US10521628
申请日:2003-07-15
申请人: Neville Boden , Amalia Agelli , Eileen Ingham , Jennifer Kirkham
发明人: Neville Boden , Amalia Agelli , Eileen Ingham , Jennifer Kirkham
CPC分类号: A61L27/22 , C07K14/001
摘要: There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.
摘要翻译: 描述了包括丝带,原纤维或纤维的材料,其特征在于,每个条带,原纤维或纤维在β-片带状亚结构中具有肽的反向平行布置。
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公开(公告)号:US20100040880A1
公开(公告)日:2010-02-18
申请号:US12539810
申请日:2009-08-12
申请人: Rudolf J. Koopmans , Amalia Aggeli , Eileen Ingham
发明人: Rudolf J. Koopmans , Amalia Aggeli , Eileen Ingham
CPC分类号: D01D5/0084 , D01D5/0985 , D06M15/15 , D06M23/005 , Y10T428/2967 , Y10T428/2969
摘要: The present invention generally relates to peptide-coated fibers, processes of fabricating said fibers, and articles incorporating said fibers.
摘要翻译: 本发明一般涉及肽包被的纤维,制造所述纤维的方法和掺入所述纤维的制品。
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公开(公告)号:US20100040879A1
公开(公告)日:2010-02-18
申请号:US12539805
申请日:2009-08-12
申请人: Rudolf J. Koopmans , Amalia Aggeli , Eileen Ingham
发明人: Rudolf J. Koopmans , Amalia Aggeli , Eileen Ingham
IPC分类号: D02G3/00
CPC分类号: D06M15/15 , D06M23/005 , Y10T428/2933
摘要: The present invention generally relates to peptide-coated fibers, processes of fabricating said fibers, and articles incorporating said fibers.
摘要翻译: 本发明一般涉及肽包被的纤维,制造所述纤维的方法和掺入所述纤维的制品。
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公开(公告)号:US07354749B2
公开(公告)日:2008-04-08
申请号:US10478198
申请日:2002-05-20
申请人: John Fisher , Catherine Booth , Eileen Ingham
发明人: John Fisher , Catherine Booth , Eileen Ingham
CPC分类号: A61L27/3687 , A61L27/3633
摘要: A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors.
摘要翻译: 制备用于植入的基质或组织工程生物材料的方法,特别是在植入之前改进基质或组织工程化生物材料脱细胞化的方法。 该方法采用单一阴离子洗涤剂与蛋白酶抑制剂组合。
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公开(公告)号:US08828448B2
公开(公告)日:2014-09-09
申请号:US12295190
申请日:2007-03-28
CPC分类号: A61K35/22 , A61F2/042 , A61L27/3604 , A61L27/3679 , A61L27/3687 , A61L27/38 , A61L2430/00 , A61L2430/22 , A61L2430/40 , C12N5/0068 , C12N5/0605 , C12N2509/00 , C12N2533/92 , G01N33/5088
摘要: The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularization is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.
摘要翻译: 本发明提供了一种生产天然的无细胞基质支架的改进方法,用于随后用于组织工程化替代诸如膀胱的组织。 脱细胞化在膨胀或膨胀的膀胱上进行,产品保持天然材料的强度和顺应性。 本发明还提供了基质支架作为伤口愈合材料的用途,并且在体外研究组织结构和功能。
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