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公开(公告)号：US20100040880A1
公开(公告)日：2010-02-18
申请号：US12539810
申请日：2009-08-12
申请人： Rudolf J. Koopmans , Amalia Aggeli , Eileen Ingham
发明人： Rudolf J. Koopmans , Amalia Aggeli , Eileen Ingham
CPC分类号： D01D5/0084 , D01D5/0985 , D06M15/15 , D06M23/005 , Y10T428/2967 , Y10T428/2969
摘要： The present invention generally relates to peptide-coated fibers, processes of fabricating said fibers, and articles incorporating said fibers.
摘要翻译： 本发明一般涉及肽包被的纤维，制造所述纤维的方法和掺入所述纤维的制品。
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公开(公告)号：US07354749B2
公开(公告)日：2008-04-08
申请号：US10478198
申请日：2002-05-20
申请人： John Fisher , Catherine Booth , Eileen Ingham
发明人： John Fisher , Catherine Booth , Eileen Ingham
CPC分类号： A61L27/3687 , A61L27/3633
摘要： A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors.
摘要翻译： 制备用于植入的基质或组织工程生物材料的方法，特别是在植入之前改进基质或组织工程化生物材料脱细胞化的方法。 该方法采用单一阴离子洗涤剂与蛋白酶抑制剂组合。
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公开(公告)号：US09510933B2
公开(公告)日：2016-12-06
申请号：US13876429
申请日：2011-09-26
申请人： Eileen Ingham , John Fisher , Stacy-Paul Wilshaw
发明人： Eileen Ingham , John Fisher , Stacy-Paul Wilshaw
CPC分类号： A61F2/06 , A61L27/3625 , A61L27/3695 , A61L27/507 , A61L2430/40
摘要： A product comprising a natural acellular xenogenic vascular tissue matrix having at least an 80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery.
摘要翻译： 一种产品，其包含与未处理的对照血管组织基质相比具有至少80％的DNA含量降低的天然无细胞异种血管组织基质，并且通过基本上不含能够与预先形成的人抗体反应的抗原决定基因而具有抗原惰性 而不具有基本上激活补体的能力。 本发明还包括制备这些产品的方法和产品的用途，特别是在旁路手术中。
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公开(公告)号：US08956411B2
公开(公告)日：2015-02-17
申请号：US12514703
申请日：2007-11-13
申请人： Eileen Ingham , John Fisher , Thomas Stapleton , Joanne Ingram
发明人： Eileen Ingham , John Fisher , Thomas Stapleton , Joanne Ingram
CPC分类号： A61L27/3612 , A61F2/3872 , A61L27/3683 , A61L2430/40
摘要： The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised.
摘要翻译： 本发明涉及一种制备组织基质的方法及其随后用于更换和/或修复损伤或有缺陷的半月板。 本发明还提供了基本上脱细胞的半月板组织。
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公开(公告)号：US08586539B2
公开(公告)日：2013-11-19
申请号：US12729046
申请日：2010-03-22
申请人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号： C07K7/06 , A61K8/64 , A61K47/42 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/52 , A61L27/56 , A61L27/60 , A61L31/047 , A61L31/14 , A61L2400/18 , A61L2430/02 , A61L2430/12 , A61L2430/32 , A61L2430/34 , A61Q5/00 , A61Q11/00 , A61Q19/00 , C09K8/62 , C09K2208/08
摘要： There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a β-sheet tape-like substructure.
摘要翻译： 描述了包括带，带，原纤维或纤维的材料，其特征在于，每个带，原纤维或纤维在β-片带状亚结构中具有肽的反向平行布置。
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公开(公告)号：US20100234304A1
公开(公告)日：2010-09-16
申请号：US12729046
申请日：2010-03-22
申请人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号： C07K7/06 , A61K8/64 , A61K47/42 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/52 , A61L27/56 , A61L27/60 , A61L31/047 , A61L31/14 , A61L2400/18 , A61L2430/02 , A61L2430/12 , A61L2430/32 , A61L2430/34 , A61Q5/00 , A61Q11/00 , A61Q19/00 , C09K8/62 , C09K2208/08
摘要： There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a β-sheet tape-like substructure.
摘要翻译： 描述了包括带，带，原纤维或纤维的材料，其特征在于，每个条带，原纤维或纤维具有在“带状”底层结构中的肽的反向平行布置。
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公开(公告)号：US20130012457A1
公开(公告)日：2013-01-10
申请号：US13551878
申请日：2012-07-18
申请人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
CPC分类号： C07K14/001 , A61K6/0002 , A61K6/02 , A61K6/08 , A61K8/042 , A61K8/64 , A61K47/42 , A61K47/64 , A61K47/6903 , A61K2800/40 , A61L27/22 , A61L27/227 , A61L27/38 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , A61Q5/00 , A61Q19/00 , C07K7/06 , C12N5/0068 , C12N2533/50
摘要： There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
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公开(公告)号：US07700721B2
公开(公告)日：2010-04-20
申请号：US10521628
申请日：2003-07-15
申请人： Neville Boden , Amalia Agelli , Eileen Ingham , Jennifer Kirkham
发明人： Neville Boden , Amalia Agelli , Eileen Ingham , Jennifer Kirkham
CPC分类号： A61L27/22 , C07K14/001
摘要： There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.
摘要翻译： 描述了包括丝带，原纤维或纤维的材料，其特征在于，每个条带，原纤维或纤维在β-片带状亚结构中具有肽的反向平行布置。
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公开(公告)号：US20060154852A1
公开(公告)日：2006-07-13
申请号：US10521628
申请日：2003-07-15
申请人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
发明人： Neville Boden , Amalia Aggeli , Eileen Ingham , Jennifer Kirkham
IPC分类号： A61K38/00
CPC分类号： A61L27/22 , C07K14/001
摘要： There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.
摘要翻译： 描述了包括丝带，原纤维或纤维的材料，其特征在于，每个条带，原纤维或纤维在β-片带状亚结构中具有肽的反向平行布置。
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公开(公告)号：US08828448B2
公开(公告)日：2014-09-09
申请号：US12295190
申请日：2007-03-28
CPC分类号： A61K35/22 , A61F2/042 , A61L27/3604 , A61L27/3679 , A61L27/3687 , A61L27/38 , A61L2430/00 , A61L2430/22 , A61L2430/40 , C12N5/0068 , C12N5/0605 , C12N2509/00 , C12N2533/92 , G01N33/5088
摘要： The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularization is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.
摘要翻译： 本发明提供了一种生产天然的无细胞基质支架的改进方法，用于随后用于组织工程化替代诸如膀胱的组织。 脱细胞化在膨胀或膨胀的膀胱上进行，产品保持天然材料的强度和顺应性。 本发明还提供了基质支架作为伤口愈合材料的用途，并且在体外研究组织结构和功能。
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