Microelectrode system
    1.
    发明授权
    Microelectrode system 有权
    微电极系统

    公开(公告)号:US06811663B1

    公开(公告)日:2004-11-02

    申请号:US09700649

    申请日:2001-05-21

    IPC分类号: G01N2730

    摘要: A microelectrode system suitable for use in preparative and analytical chemistry having a laminated structure with one or more apertures. In one embodiment a microelectrode system (1) comprises alternating layers of conductor (3) and dielectric (or insulator) (4). The laminated structure (2) comprises two conductor layers (3) and two dielectric layers (4) formed on a base (5) of silicon or a polymeric material. The conducting layers (3) form electrodes in the microelectrodes system (1). The laminated structure has formed within it an aperture in the form of a well (6) being open at one end (7) and closed at the opposite end (8). In another embodiment, the apertures take the form of through holes.

    摘要翻译: 适用于具有一个或多个孔的层压结构的制备和分析化学中的微电极系统。 在一个实施例中,微电极系统(1)包括导体(3)和电介质(或绝缘体)(4)的交替层。 层压结构(2)包括形成在硅或聚合物材料的基底(5)上的两个导体层(3)和两个电介质层(4)。 导电层(3)在微电极系统(1)中形成电极。 层压结构在其中形成为在一端(7)处开口并在相对端(8)处封闭的孔(6)形式的孔。 在另一个实施例中,孔呈通孔的形式。

    Detecting analytes
    2.
    发明授权
    Detecting analytes 有权
    检测分析物

    公开(公告)号:US08778157B2

    公开(公告)日:2014-07-15

    申请号:US12921902

    申请日:2009-03-11

    IPC分类号: G01N27/447 G01N27/327

    摘要: Provided is a method for processing a sample, which method comprises: a) contacting a binding phase, which binding phase is capable of binding an analyte, with the sample in the presence of a medium; b) applying across the medium a first alternating field composed of a plurality of pulses and having a first frequency, a first pulse duration and a first pulse rise time; c) optionally applying across the medium a second alternating field; and d) thereby influencing the sample and/or the binding phase in the medium.

    摘要翻译: 提供了一种处理样品的方法,该方法包括:a)在介质存在下使结合相与结合相结合,该结合相能够与分析物结合; b)在介质上施加由多个脉冲组成的具有第一频率,第一脉冲持续时间和第一脉冲上升时间的第一交变场; c)任选地在所述介质上施加第二交变场; 和d)从而影响培养基中的样品和/或结合相。

    DETECTING ANALYTES
    3.
    发明申请
    DETECTING ANALYTES 有权
    检测分析

    公开(公告)号:US20110031123A1

    公开(公告)日:2011-02-10

    申请号:US12921902

    申请日:2009-03-11

    IPC分类号: G01N27/26 G01N27/447

    摘要: Provided is a method for processing a sample, which method comprises:a) contacting a binding phase, which binding phase is capable of binding an analyte, with the sample in the presence of a medium;b) applying across the medium a first alternating field composed of a plurality of pulses and having a first frequency, a first pulse duration and a first pulse rise time;c) optionally applying across the medium a second alternating field; andd) thereby influencing the sample and/or the binding phase in the medium.

    摘要翻译: 提供了一种处理样品的方法,该方法包括:a)在介质存在下使结合相与结合相结合,该结合相能够与分析物结合; b)在介质上施加由多个脉冲组成的具有第一频率,第一脉冲持续时间和第一脉冲上升时间的第一交变场; c)任选地在所述介质上施加第二交变场; 和d)从而影响培养基中的样品和/或结合相。

    TRIPLE FUNCTION ELECTRODES
    4.
    发明申请
    TRIPLE FUNCTION ELECTRODES 审中-公开
    三功能电极

    公开(公告)号:US20110100820A1

    公开(公告)日:2011-05-05

    申请号:US12994424

    申请日:2009-03-20

    IPC分类号: G01N27/447

    摘要: Provided is a device for assaying one or more analytes, said device comprising an electrode, a means for optical detection; and a means for electrochemical detection, wherein the device is configured such that the electrode is capable of promoting transport of an analyte when a field is applied to the analyte via the electrode, and wherein the means for electrochemical detection employs the electrode and the means for optical detection employs the electrode, and wherein the device is configured to carry out dielectrophoresis.Further provided is the use of the device of the present invention for promoting transport of an analyte, detecting the optical properties of the analyte and detecting the electrochemical properties of the analyte.Also provided is method for assaying one or more analytes, which method comprises the steps of: promoting transport of an analyte, performing an optical measurement of the analyte and performing an electrochemical measurement of the analyte, which method employs the device of the present invention.

    摘要翻译: 提供了一种用于测定一种或多种分析物的装置,所述装置包括电极,用于光学检测的装置; 以及用于电化学检测的装置,其中所述装置被配置为使得当通过所述电极将场施加到所述分析物时,所述电极能够促进分析物的运输,并且其中所述用于电化学检测的装置使用所述电极和所述装置 光学检测使用电极,并且其中该器件被配置为执行介电电泳。 还提供了本发明的装置用于促进分析物的运输,检测分析物的光学性质和检测分析物的电化学性质的用途。 还提供了用于测定一种或多种分析物的方法,该方法包括以下步骤:促进分析物的转运,进行分析物的光学测量并进行分析物的电化学测量,该方法采用本发明的装置。

    Biomolecular devices
    5.
    发明申请
    Biomolecular devices 审中-公开
    生物分子装置

    公开(公告)号:US20070190656A1

    公开(公告)日:2007-08-16

    申请号:US10555493

    申请日:2004-05-04

    IPC分类号: G01N33/48

    摘要: The present invention provides a macromolecular switch (51) suitable for use in a data acquisition and/or processing device. The switch comprises a macromolecular structure (10) having an ion binding site (14), and is flippable between a plurality of discretely different conformations corresponding to different ion binding conditions at the ion binding site (14). The macromolecular structure (10) is provided with at least one electrochemical input device (43) for applying such different ion binding conditions to the ion binding site (14) in response to corresponding external input signals. The invention also provides a method for data acquisition and/or processing, using a macromolecular structure switch of the invention.

    摘要翻译: 本发明提供适用于数据采集和/或处理装置的大分子开关(51)。 开关包含具有离子结合位点(14)的大分子结构(10),并且可以在对应于离子结合位点(14)处的不同离子结合条件的多个离散不同构象之间进行剥离。 大分子结构(10)设置有至少一个电化学输入装置(43),用于响应于相应的外部输入信号将这种不同的离子结合条件施加到离子结合位点(14)。 本发明还提供了使用本发明的大分子结构开关进行数据采集和/或处理的方法。

    DETECTING ANALYTES USING BOTH AN OPTICAL AND AN ELECTRICAL MEASUREMENT METHOD
    7.
    发明申请
    DETECTING ANALYTES USING BOTH AN OPTICAL AND AN ELECTRICAL MEASUREMENT METHOD 审中-公开
    使用两种光学和电气测量方法检测分析

    公开(公告)号:US20100203516A1

    公开(公告)日:2010-08-12

    申请号:US12524562

    申请日:2008-01-25

    摘要: Provided is a method for detecting an analyte, wherein the analyte is labelled with one or more labels relatable to the analyte, which method comprises: a) performing an optical detection method on the labelled analyte to obtain optical data from the one or more labels; b) performing an electrical detection method on the labelled analyte to obtain electrical data from the one or more labels; and c) determining the identity and/or quantity of the analyte from both the optical and electrical data. Further provided is a method for detecting a plurality of analytes, wherein the each different analyte is labelled with one or more different labels relatable to the analyte, which method comprises: a) performing an optical detection method on a plurality of labelled analytes to obtain optical data from the labels; b) performing an electrochemical detection method on the plurality of labelled analytes to obtain electrical data from the labels; and c) determining the identity and/or quantity of the plurality of analytes from both the optical and electrical data.

    摘要翻译: 提供了一种用于检测分析物的方法,其中所述分析物用与所述分析物相关的一个或多个标记进行标记,所述方法包括:a)对所述标记的分析物执行光学检测方法以从所述一个或多个标签获得光学数据; b)对标记的分析物执行电检测方法以从一个或多个标签获得电数据; 以及c)从所述光学和电学数据两者确定所述分析物的身份和/或数量。 还提供了一种用于检测多个分析物的方法,其中每个不同的分析物用与分析物相关的一个或多个不同标记进行标记,该方法包括:a)对多个标记的分析物进行光学检测方法以获得光学 标签数据; b)对所述多个标记的分析物进行电化学检测方法以从所述标签获得电数据; 以及c)从所述光学和电气数据两者确定所述多个分析物的身份和/或数量。