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公开(公告)号：US20060234328A1
公开(公告)日：2006-10-19
申请号：US11326985
申请日：2006-01-05
申请人： Nicholas Duesbery , Craig Webb , Stephen Leppla , George Woude
发明人： Nicholas Duesbery , Craig Webb , Stephen Leppla , George Woude
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
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公开(公告)号：US06485925B1
公开(公告)日：2002-11-26
申请号：US09623104
申请日：2000-12-13
IPC分类号： C12Q137
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
摘要翻译： 本发明涉及筛选致死因子丝裂原活化蛋白激酶激酶（MAPKK）蛋白酶活性的调节剂，同系物和模拟物的体外和离体方法，以及通过向转化细胞施用LF来治疗癌症的方法。
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公开(公告)号：US06893835B2
公开(公告)日：2005-05-17
申请号：US10093248
申请日：2002-03-05
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
摘要翻译： 本发明涉及筛选致死因子丝裂原活化蛋白激酶激酶（MAPKK）蛋白酶活性的调节剂，同系物和模拟物的体外和离体方法，以及通过向转化细胞施用LF来治疗癌症的方法。
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公开(公告)号：US07183071B2
公开(公告)日：2007-02-27
申请号：US11326985
申请日：2006-01-05
IPC分类号： G01N33/567 , G01N33/53 , C12Q1/37 , C12N9/54 , C12N9/12
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
摘要翻译： 本发明涉及筛选致死因子丝裂原活化蛋白激酶激酶（MAPKK）蛋白酶活性的调节剂，同系物和模拟物的体外和离体方法，以及通过向转化细胞施用LF来治疗癌症的方法。
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公开(公告)号：US06911203B2
公开(公告)日：2005-06-28
申请号：US10093200
申请日：2002-03-05
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
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公开(公告)号：US07056693B2
公开(公告)日：2006-06-06
申请号：US11112137
申请日：2005-04-22
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
摘要翻译： 本发明涉及筛选致死因子丝裂原活化蛋白激酶激酶（MAPKK）蛋白酶活性的调节剂，同系物和模拟物的体外和离体方法，以及通过向转化细胞施用LF来治疗癌症的方法。
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公开(公告)号：US20050196822A1
公开(公告)日：2005-09-08
申请号：US11112137
申请日：2005-04-22
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/37 , G01N2333/32 , G01N2500/00
摘要： The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
摘要翻译： 本发明涉及筛选致死因子丝裂原活化蛋白激酶激酶（MAPKK）蛋白酶活性的调节剂，同系物和模拟物的体外和离体方法，以及通过向转化细胞施用LF来治疗癌症的方法。
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8.发明申请Monoclonal Antibodies That Neutralize Anthrax Protective Antigen (PA) Toxin 有权中和炭疽保护性抗原（PA）毒素的单克隆抗体公开(公告)号：US20100074892A1
公开(公告)日：2010-03-25
申请号：US11793735
申请日：2005-12-21
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽保护性抗原（PA）毒素的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段，其保留了炭疽PA毒素结合能力，完全人或人源化抗体保留了炭疽杆菌PA毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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9.发明申请Multimeric protein toxins to target cells having multiple identifying characteristics 有权多聚蛋白毒素靶向具有多重鉴定特征的细胞公开(公告)号：US20050255083A1
公开(公告)日：2005-11-17
申请号：US11055557
申请日：2005-02-09
申请人： Stephen Leppla , Shi-Hui Liu , Thomas Bugge
发明人： Stephen Leppla , Shi-Hui Liu , Thomas Bugge
IPC分类号： A61K38/00 , A61K38/19 , A61K39/02 , A61K39/40 , A61K47/48 , C07K14/195 , C07K14/32 , C07K16/30
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/665 , C07K14/32 , C07K16/30 , C07K2319/00 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating diseases.
摘要翻译： 本发明提供包含改良的细菌毒素的组合物和用于使用经修饰的细菌毒素靶向特定细胞群体并用于治疗疾病的方法。
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10.发明授权Monoclonal antibodies that neutralize anthrax protective antigen (PA) toxin 有权中和炭疽保护性抗原（PA）毒素的单克隆抗体公开(公告)号：US08685396B2
公开(公告)日：2014-04-01
申请号：US11793735
申请日：2005-12-21
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N5/10 , G01N33/53
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和炭疽保护性抗原（PA）毒素的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段，其保留了炭疽PA毒素结合能力，完全人或人源化抗体保留了炭疽杆菌PA毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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