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公开(公告)号：US09029540B2
公开(公告)日：2015-05-12
申请号：US14313085
申请日：2014-06-24
申请人： Nizar Haddad , Heewon Lee , Bo Qu , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Nizar Haddad , Heewon Lee , Bo Qu , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07F15/00 , C07D405/04 , B01J31/22 , C07D215/20 , C07D209/04 , C07D333/54 , C07D307/79 , C07C29/145 , C07D231/56 , B01J23/46 , B01J31/24 , C07C29/156 , C07B53/00
CPC分类号： B01J31/2295 , B01J23/462 , B01J31/1805 , B01J31/1815 , B01J31/1825 , B01J31/24 , B01J31/2471 , B01J2231/643 , B01J2531/0238 , B01J2531/821 , C07B53/00 , C07C29/145 , C07C29/156 , C07D209/04 , C07D215/20 , C07D231/56 , C07D307/79 , C07D333/54 , C07D405/04 , C07F15/0046 , C07F15/0053 , C07C35/23 , C07C35/52 , C07C33/46 , C07C33/22
摘要： Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R1 and the moiety are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and excellent selectivities.
摘要翻译： 公开了式（Ia）和（Ib）的新型钌化合物：其中R 1和该部分在本文中定义。 还公开了使用这些新型钌化合物作为催化剂用于具有高反应性和优异的选择性的酮的不对称氢化和转移氢化的方法。
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公开(公告)号：US20130137902A1
公开(公告)日：2013-05-30
申请号：US13635671
申请日：2011-03-31
申请人： Nizar Haddad , Bo Qu , Sonia Rodriguez , Chris Senanayake , Wenjun Tang , Xudong Wei , Nathan K. Yee
发明人： Nizar Haddad , Bo Qu , Sonia Rodriguez , Chris Senanayake , Wenjun Tang , Xudong Wei , Nathan K. Yee
IPC分类号： C07F9/6571
CPC分类号： C07F9/657163 , C07B37/04 , C07F9/65683 , C07F9/65685
摘要： Phosphine ligands of the formula Ia, IB and mixtures thereof.
摘要翻译： 式Ia，IB的膦配体及其混合物。
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公开(公告)号：US09096626B2
公开(公告)日：2015-08-04
申请号：US13635671
申请日：2011-03-31
申请人： Nizar Haddad , Bo Qu , Sonia Rodriguez , Chris Senanayake , Wenjun Tang , Xudong Wei , Nathan K. Yee
发明人： Nizar Haddad , Bo Qu , Sonia Rodriguez , Chris Senanayake , Wenjun Tang , Xudong Wei , Nathan K. Yee
IPC分类号： C07F9/6571 , C07B37/04 , C07F9/6568
CPC分类号： C07F9/657163 , C07B37/04 , C07F9/65683 , C07F9/65685
摘要： Phosphine ligands of the formula Ia, IB and mixtures thereof.
摘要翻译： 式Ia，IB的膦配体及其混合物。
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![Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein](/abs-image/US/2014/02/18/US08653282B2/abs.jpg.150x150.jpg)
4.发明授权Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein 有权制备二氢噻吩并[3,2-D]嘧啶及其中使用的中间体公开(公告)号：US08653282B2
公开(公告)日：2014-02-18
申请号：US12738152
申请日：2008-10-15
申请人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
发明人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
IPC分类号： C07D333/32 , C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
摘要翻译： 本发明涉及制备式1的二氢噻吩并嘧啶的改进方法及其中间体，其中X是SO或SO 2，优选SO，其中RA，R 1，R 2，R 3，R 4和R 5具有在说明书中给出的含义 。 根据本发明的方法比现有方法更适合于大规模合成所述化合物，因为新的合成方法避免了步骤之间的蒸馏和色谱纯化并导致所需产物的更高的总产率。
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5.发明授权Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof 有权制备含有4-和5-咪唑基环的细胞因子抑制化合物的方法及其中间体公开(公告)号：US07858804B2
公开(公告)日：2010-12-28
申请号：US12295636
申请日：2007-04-16
申请人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , C07D233/64 , C07F7/0812
摘要： Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the intermediates useful in the processes disclosed herein.
摘要翻译： 公开的是制备含有4-和5-咪唑基环的化合物的方法，还公开了可用于本文公开的方法的中间体。
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![PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN](/abs-image/US/2010/09/02/US20100222585A1/abs.jpg.150x150.jpg)
6.发明申请PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN 有权二氢O O O O O IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN公开(公告)号：US20100222585A1
公开(公告)日：2010-09-02
申请号：US12738152
申请日：2008-10-15
申请人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
发明人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
IPC分类号： C07D491/04
CPC分类号： C07D495/04
摘要： The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said pounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
摘要翻译： 本发明涉及制备式1的二氢噻吩并嘧啶的改进方法及其中间体，其中X是SO或SO 2，优选SO，其中RA，R 1，R 2，R 3，R 4和R 5具有在说明书中给出的含义 。 根据本发明的方法比现有方法更适合于大规模合成所述磅，因为新的合成方法避免了步骤之间的蒸馏和色谱纯化并导致所需产物的更高的总产率。
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7.发明申请Process for Making Cytokine Inhibiting Compounds Containing 4- and 5-Imidazolyl Rings and the Intermediates Thereof 有权制备含有4-和5-咪唑环的细胞因子抑制化合物及其中间体的方法公开(公告)号：US20090137815A1
公开(公告)日：2009-05-28
申请号：US12295636
申请日：2007-04-16
申请人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07F7/02 , C07D403/04 , C07D233/54
CPC分类号： C07D403/04 , C07D233/64 , C07F7/0812
摘要： Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the inter-mediates useful in the processes disclosed herein.
摘要翻译： 公开的是制备含有4-和5-咪唑基环的化合物的方法，还公开了可用于本文公开的方法的中间体。
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公开(公告)号：US07714127B2
公开(公告)日：2010-05-11
申请号：US11538465
申请日：2006-10-04
申请人： Guisheng Li , Jianxiu Liu , Zhi-Hui (Bruce) Lu , Ming Shen , Sonia Rodriguez , Vittorio Farina
发明人： Guisheng Li , Jianxiu Liu , Zhi-Hui (Bruce) Lu , Ming Shen , Sonia Rodriguez , Vittorio Farina
IPC分类号： C07D413/06
CPC分类号： C07D213/38
摘要： Disclosed are processes to produce a compound of the formula (I):
摘要翻译： 公开了制备式（I）化合物的方法：
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公开(公告)号：US20070105857A1
公开(公告)日：2007-05-10
申请号：US11538465
申请日：2006-10-04
申请人： Guisheng Li , Jianxiu Liu , Zhi-Hui (Bruce) Lu , Ming Shen , Sonia Rodriguez , Vittorio Farina
发明人： Guisheng Li , Jianxiu Liu , Zhi-Hui (Bruce) Lu , Ming Shen , Sonia Rodriguez , Vittorio Farina
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D213/38
摘要： Disclosed are processes to produce a compound of the formula (I):
摘要翻译： 公开了制备式（I）化合物的方法：
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公开(公告)号：US08946203B2
公开(公告)日：2015-02-03
申请号：US13785034
申请日：2013-03-05
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
IPC分类号： C07D519/00 , C07D491/04 , C07D487/08 , A61K31/357 , C07D491/052 , C07D405/10 , C07D295/096 , C07D295/155 , C07D513/04 , C07D405/14 , C07D319/20 , C07D405/12 , C07D487/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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