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公开(公告)号：US20120283178A1
公开(公告)日：2012-11-08
申请号：US13517109
申请日：2010-02-26
CPC分类号： A61K38/12 , A23L2/52 , A23L33/18 , A23V2002/00 , A61K9/0053 , A61K31/496 , A61K31/498
摘要： The present invention aims to provide antidepressants which are free from the problem of side effects and are excellent in safety. The present invention also aims to provide learning motivation improvers which are useful for improvement of learning motivation and can be ingested continuously.The present invention provides antidepressants and learning motivation improvers, each comprising a cyclic dipeptide with the 2,5-diketopiperazine structure as an active ingredient.
摘要翻译： 本发明的目的在于提供不含副作用的问题的抗抑郁药，安全性优异。 本发明还旨在提供一种学习动机改进者，其对于改善学习动机是有用的，并且可以持续摄取。 本发明提供抗抑郁药和学习动机改善剂，每一种都包含具有2,5-二酮哌嗪结构的环状二肽作为活性成分。
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2.发明申请MEDICINAL COMPOSITION, FOOD OR DRINK HAVING EFFECT OF ENHANCING SYMPATHETIC NERVOUS ACTIVITY 审中-公开药物组合物，食物或饮料具有增强反应性神经活性的作用公开(公告)号：US20100150890A1
公开(公告)日：2010-06-17
申请号：US12593438
申请日：2008-03-28
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Tomohiro Rogi , Hajime Komura , Katsuya Nagai
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Tomohiro Rogi , Hajime Komura , Katsuya Nagai
摘要： It is intended to provide a safe composition for preventing or treating obesity or related complications which has an autonomic nervous control effect, in particular, an effect of enhancing sympathetic nervous activity and an effect of promoting energy metabolism. Thus, a medicinal composition, a food or a drink containing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and having an autonomic nervous control effect and an effect of promoting energy metabolism is provided.
摘要翻译： 本发明旨在提供一种用于预防或治疗具有自主神经控制作用的肥胖或相关并发症的安全组合物，特别是增强交感神经活性和促进能量代谢的作用。 因此，含有2,3-二氢-3,5-二羟基-6-甲基-4H-吡喃-4-酮的药物组合物，食品或饮料具有自主神经控制作用和促进能量代谢的作用是 提供。
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3.发明授权Pharmaceutical, food or beverage having inhibitory activity on serotonin transporter 有权对5-羟色胺转运蛋白具有抑制活性的药物，食品或饮料公开(公告)号：US08669267B2
公开(公告)日：2014-03-11
申请号：US13059819
申请日：2009-08-06
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00
CPC分类号： C07D471/04 , A23C9/1307 , A23F5/243 , A23G9/32 , A23L2/02 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/473 , A61K35/74 , C12G3/04 , A23V2200/3204 , A23V2250/032 , A23V2250/606 , A23V2250/5072 , A23V2200/31
摘要： There is provided a pharmaceutical agent, food, or beverage for treating or preventing a disease or condition that can be ameliorated by inhibiting serotonin reuptake, comprising a clinically-effective amount of (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid.
摘要翻译： 提供了用于治疗或预防可以通过抑制血清素再摄取而改善的疾病或病症的药剂，食品或饮料，其包含临床有效量的（1S，3S）-1-甲基-1,2,3 ，4-四氢-β-咔啉-3-羧酸。
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4.发明申请PHARMACEUTICAL, FOOD OR BEVERAGE HAVING INHIBITORY ACTIVITY ON SEROTONIN TRANSPORTER 有权糖精运输机的药物，食品或饮料中具有抑制活性公开(公告)号：US20110152309A1
公开(公告)日：2011-06-23
申请号：US13059819
申请日：2009-08-06
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura
IPC分类号： A61K31/437 , C07D471/04 , C12N1/20 , C12P13/04 , A61P25/24
CPC分类号： C07D471/04 , A23C9/1307 , A23F5/243 , A23G9/32 , A23L2/02 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/473 , A61K35/74 , C12G3/04 , A23V2200/3204 , A23V2250/032 , A23V2250/606 , A23V2250/5072 , A23V2200/31
摘要： There is provided a pharmaceutical agent, food, or beverage for treating or preventing a disease or condition that can be ameliorated by inhibiting serotonin reuptake, comprising a clinically-effective amount of (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid.
摘要翻译： 提供了用于治疗或预防可通过抑制血清素再摄取而改善的疾病或病症的药剂，食品或饮料，其包含临床有效量的（1S，3S）-1-甲基-1,2,3 ，4-四氢 - 咔啉-3-羧酸。
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5.发明申请MEDICINAL COMPOSITION, FOOD OR DRINK HAVING EFFECT OF ENHANCING PARASYMPATHETIC NERVOUS ACTIVITY 有权药物组合物，食物或饮料具有增强PARASYMPATHETIC NERVOUS活动的作用公开(公告)号：US20100150891A1
公开(公告)日：2010-06-17
申请号：US12593468
申请日：2008-03-28
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura , Katsuya Nagai
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura , Katsuya Nagai
IPC分类号： A61K31/192 , A61K35/74 , A61P25/00 , C12P7/42
CPC分类号： A61K35/747 , A23L33/10 , A23V2002/00 , A61K31/19 , A61K35/744 , A61K35/745 , A23V2250/042 , A23V2200/322
摘要： It is intended to provide a safe composition for treating a disease or condition relating to autonomic nervous activity which has an autonomic nervous control effect; in particular, an effect of enhancing parasympathetic nervous activity. Thus, a medicinal composition, a food or a drink containing L-phenyl lactic acid and/or D-phenyl lactic acid and having an autonomic nervous control effect is provided.
摘要翻译： 旨在提供一种用于治疗与具有自主神经控制作用的自主神经活动有关的疾病或病症的安全组合物; 特别是增强副交感神经活动的作用。 因此，提供了含有L-苯基乳酸和/或D-苯基乳酸并具有自主神经控制作用的药物组合物，食品或饮料。
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6.发明授权Medicinal composition, food or drink having effect of enhancing parasympathetic nervous activity 有权具有促进副交感神经活动作用的药物组合物，食物或饮料公开(公告)号：US08492442B2
公开(公告)日：2013-07-23
申请号：US12593468
申请日：2008-03-28
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura , Katsuya Nagai
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura , Katsuya Nagai
CPC分类号： A61K35/747 , A23L33/10 , A23V2002/00 , A61K31/19 , A61K35/744 , A61K35/745 , A23V2250/042 , A23V2200/322
摘要： It is intended to provide a safe composition for treating a disease or condition relating to autonomic nervous activity which has an autonomic nervous control effect; in particular, an effect of enhancing parasympathetic nervous activity. Thus, a medicinal composition, a food or a drink containing L-phenyl lactic acid and/or D-phenyl lactic acid and having an autonomic nervous control effect is provided.
摘要翻译： 旨在提供一种用于治疗与具有自主神经控制作用的自主神经活动有关的疾病或病症的安全组合物; 特别是增强副交感神经活动的作用。 因此，提供了含有L-苯基乳酸和/或D-苯基乳酸并具有自主神经控制作用的药物组合物，食品或饮料。
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公开(公告)号：US09518282B2
公开(公告)日：2016-12-13
申请号：US13997683
申请日：2011-12-27
申请人： Eiichiro Ono , Nobuo Tsuruoka
发明人： Eiichiro Ono , Nobuo Tsuruoka
IPC分类号： C12N9/10 , C12N15/09 , C12N15/82 , C12P19/18 , A23B9/00 , A23L1/00 , A61K36/31 , C12P19/44 , A61K8/60 , A61Q19/00 , A61K8/64
CPC分类号： C12P19/44 , A23L27/36 , A61K8/602 , A61K8/64 , A61Q19/00 , C12N9/1048 , C12N9/1051 , C12N15/8257 , C12P19/18 , C12Y204/01 , Y02P20/52
摘要： The object of the present invention is to provide a novel method for producing a terpene 8-glycoside.The present invention provides a method for producing a terpene 8-glycoside by means of glycosyltransferase acting on the 8-position of terpenes. The present invention provides a transformant transformed with a gene for the glycosyltransferase acting on the 8-position of terpenes and a method for producing such a transformant. The present invention provides a plant modified to suppress the expression of a protein having glycosylation activity on the 8-position of a monoterpene compound.
摘要翻译： 本发明提供了通过作用于萜烯8位的糖基转移酶来制备萜烯8-糖苷的方法。 本发明提供了用作用于萜烯8位的糖基转移酶的基因转化的转化体及其生产方法。 本发明提供了修饰以抑制在单萜化合物的8-位具有糖基化活性的蛋白质的表达的植物。
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公开(公告)号：US20140020137A1
公开(公告)日：2014-01-16
申请号：US13997683
申请日：2011-12-27
申请人： Eiichiro Ono , Nobuo Tsuruoka
发明人： Eiichiro Ono , Nobuo Tsuruoka
CPC分类号： C12P19/44 , A23L27/36 , A61K8/602 , A61K8/64 , A61Q19/00 , C12N9/1048 , C12N9/1051 , C12N15/8257 , C12P19/18 , C12Y204/01 , Y02P20/52
摘要： The object of the present invention is to provide a novel method for producing a terpene 8-glycoside.The present invention provides a method for producing a terpene 8-glycoside by means of glycosyltransferase acting on the 8-position of terpenes. The present invention provides a transformant transformed with a gene for the glycosyltransferase acting on the 8-position of terpenes and a method for producing such a transformant. The present invention provides a plant modified to suppress the expression of a protein having glycosylation activity on the 8-position of a monoterpene compound.
摘要翻译： 本发明的目的是提供一种制备萜烯8-糖苷的新方法。 本发明提供了通过作用于萜烯8位的糖基转移酶来制备萜烯8-糖苷的方法。 本发明提供了用作用于萜烯8位的糖基转移酶的基因转化的转化体及其生产方法。 本发明提供了修饰以抑制在单萜化合物的8-位具有糖基化活性的蛋白质的表达的植物。
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公开(公告)号：US5808032A
公开(公告)日：1998-09-15
申请号：US157101
申请日：1994-04-05
CPC分类号： C07K16/082
摘要： The L and H chains of the human anti-HBs antibody can be produced by the genetic recombination techniques to provide the desired human anti-HBs antibody easily on a large scale. The invention relates to nucleotide base sequences coding for the respective polypeptides that constitute the L and H chains of the anti-HBs antibody, expression plasmids containing them, and transformants prepared by transformation with the expression plasmids.
摘要翻译： PCT No.PCT / JP93 / 00396 Sec。 371日期1994年04月5日 102（e）日期1994年4月5日PCT 1993年3月30日PCT公布。 WO93 / 20205 PCT出版物 日期1993年10月14日人抗HBs抗体的L链和H链可以通过遗传重组技术产生，以便大规模提供所需的人类抗HBs抗体。 本发明涉及编码构成抗HBs抗体的L链和H链的各种多肽的核苷酸碱基序列，含有它们的表达质粒和通过用表达质粒转化制备的转化体。
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公开(公告)号：US5972886A
公开(公告)日：1999-10-26
申请号：US611977
申请日：1996-03-06
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91 , C07K14/52 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host.The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.
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