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公开(公告)号：US5808032A
公开(公告)日：1998-09-15
申请号：US157101
申请日：1994-04-05
CPC分类号： C07K16/082
摘要： The L and H chains of the human anti-HBs antibody can be produced by the genetic recombination techniques to provide the desired human anti-HBs antibody easily on a large scale. The invention relates to nucleotide base sequences coding for the respective polypeptides that constitute the L and H chains of the anti-HBs antibody, expression plasmids containing them, and transformants prepared by transformation with the expression plasmids.
摘要翻译： PCT No.PCT / JP93 / 00396 Sec。 371日期1994年04月5日 102（e）日期1994年4月5日PCT 1993年3月30日PCT公布。 WO93 / 20205 PCT出版物 日期1993年10月14日人抗HBs抗体的L链和H链可以通过遗传重组技术产生，以便大规模提供所需的人类抗HBs抗体。 本发明涉及编码构成抗HBs抗体的L链和H链的各种多肽的核苷酸碱基序列，含有它们的表达质粒和通过用表达质粒转化制备的转化体。
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公开(公告)号：US5972886A
公开(公告)日：1999-10-26
申请号：US611977
申请日：1996-03-06
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91 , C07K14/52 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host.The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.
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公开(公告)号：US5831030A
公开(公告)日：1998-11-03
申请号：US472659
申请日：1995-06-07
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C07K14/475 , A61K38/00
摘要： The present invention provides novel megakaryocyte differentiation factors, which are useful as therapeutic agents due to their accelerating effects on the differentiation of megakaryocytes and their thrombopoietic effects. The megakaryocyte differentiation factors of the present invention include the megakaryocyte differentiation factor having the amino acid sequence shown in SEQ ID NO: 34. The present invention also provides DNA coding for the megakaryocyte differentiation factors of the present invention, expression vectors containing the DNA, hosts transformed with the expression vectors, and processes for production of the megakaryocyte differentiation factors using transformed hosts. The present invention further provides specific antibodies to the megakaryocyte differentiation factors of the present invention.
摘要翻译： 本发明提供了新的巨核细胞分化因子，由于它们对巨核细胞的分化及其血小板生成作用的加速作用，它们可用作治疗剂。 本发明的巨核细胞分化因子包括具有SEQ ID NO：34所示的氨基酸序列的巨核细胞分化因子。本发明还提供编码本发明的巨核细胞分化因子的DNA，含有该DNA的表达载体，宿主 用表达载体转化，以及使用转化宿主生产巨核细胞分化因子的过程。 本发明还提供了针对本发明的巨核细胞分化因子的特异性抗体。
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公开(公告)号：US5874253A
公开(公告)日：1999-02-23
申请号：US474661
申请日：1995-06-07
申请人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
发明人： Masafumi Tsujimoto , Fuyuki Iwasa , Nobuo Tsuruoka , Hiroshi Nakazato , Kenju Miura , Nobuhiro Ishida , Tatsuya Kurihara , Kozo Yamaichi , Nozomi Yamaguchi
IPC分类号： A61K38/00 , A61K38/19 , A61P7/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/475 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/91 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host. The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.
摘要翻译： 一种新型巨核细胞分化因子，例如基本上由SEQ ID NO：30组成; 编码巨核细胞分化因子的DNA，包含DNA的表达载体，用表达载体转化的宿主以及使用该宿主产生巨核细胞分化因子的方法。 巨核细胞分化因子加速了在IL-3存在下巨核细胞的分化，并且作为血小板生成素，因此是涉及减少血小板的各种疾病的有效药物。
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公开(公告)号：US09518282B2
公开(公告)日：2016-12-13
申请号：US13997683
申请日：2011-12-27
申请人： Eiichiro Ono , Nobuo Tsuruoka
发明人： Eiichiro Ono , Nobuo Tsuruoka
IPC分类号： C12N9/10 , C12N15/09 , C12N15/82 , C12P19/18 , A23B9/00 , A23L1/00 , A61K36/31 , C12P19/44 , A61K8/60 , A61Q19/00 , A61K8/64
CPC分类号： C12P19/44 , A23L27/36 , A61K8/602 , A61K8/64 , A61Q19/00 , C12N9/1048 , C12N9/1051 , C12N15/8257 , C12P19/18 , C12Y204/01 , Y02P20/52
摘要： The object of the present invention is to provide a novel method for producing a terpene 8-glycoside.The present invention provides a method for producing a terpene 8-glycoside by means of glycosyltransferase acting on the 8-position of terpenes. The present invention provides a transformant transformed with a gene for the glycosyltransferase acting on the 8-position of terpenes and a method for producing such a transformant. The present invention provides a plant modified to suppress the expression of a protein having glycosylation activity on the 8-position of a monoterpene compound.
摘要翻译： 本发明提供了通过作用于萜烯8位的糖基转移酶来制备萜烯8-糖苷的方法。 本发明提供了用作用于萜烯8位的糖基转移酶的基因转化的转化体及其生产方法。 本发明提供了修饰以抑制在单萜化合物的8-位具有糖基化活性的蛋白质的表达的植物。
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公开(公告)号：US20140020137A1
公开(公告)日：2014-01-16
申请号：US13997683
申请日：2011-12-27
申请人： Eiichiro Ono , Nobuo Tsuruoka
发明人： Eiichiro Ono , Nobuo Tsuruoka
CPC分类号： C12P19/44 , A23L27/36 , A61K8/602 , A61K8/64 , A61Q19/00 , C12N9/1048 , C12N9/1051 , C12N15/8257 , C12P19/18 , C12Y204/01 , Y02P20/52
摘要： The object of the present invention is to provide a novel method for producing a terpene 8-glycoside.The present invention provides a method for producing a terpene 8-glycoside by means of glycosyltransferase acting on the 8-position of terpenes. The present invention provides a transformant transformed with a gene for the glycosyltransferase acting on the 8-position of terpenes and a method for producing such a transformant. The present invention provides a plant modified to suppress the expression of a protein having glycosylation activity on the 8-position of a monoterpene compound.
摘要翻译： 本发明的目的是提供一种制备萜烯8-糖苷的新方法。 本发明提供了通过作用于萜烯8位的糖基转移酶来制备萜烯8-糖苷的方法。 本发明提供了用作用于萜烯8位的糖基转移酶的基因转化的转化体及其生产方法。 本发明提供了修饰以抑制在单萜化合物的8-位具有糖基化活性的蛋白质的表达的植物。
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公开(公告)号：US20120283178A1
公开(公告)日：2012-11-08
申请号：US13517109
申请日：2010-02-26
CPC分类号： A61K38/12 , A23L2/52 , A23L33/18 , A23V2002/00 , A61K9/0053 , A61K31/496 , A61K31/498
摘要： The present invention aims to provide antidepressants which are free from the problem of side effects and are excellent in safety. The present invention also aims to provide learning motivation improvers which are useful for improvement of learning motivation and can be ingested continuously.The present invention provides antidepressants and learning motivation improvers, each comprising a cyclic dipeptide with the 2,5-diketopiperazine structure as an active ingredient.
摘要翻译： 本发明的目的在于提供不含副作用的问题的抗抑郁药，安全性优异。 本发明还旨在提供一种学习动机改进者，其对于改善学习动机是有用的，并且可以持续摄取。 本发明提供抗抑郁药和学习动机改善剂，每一种都包含具有2,5-二酮哌嗪结构的环状二肽作为活性成分。
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8.发明申请MEDICINAL COMPOSITION, FOOD OR DRINK HAVING EFFECT OF ENHANCING SYMPATHETIC NERVOUS ACTIVITY 审中-公开药物组合物，食物或饮料具有增强反应性神经活性的作用公开(公告)号：US20100150890A1
公开(公告)日：2010-06-17
申请号：US12593438
申请日：2008-03-28
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Tomohiro Rogi , Hajime Komura , Katsuya Nagai
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Tomohiro Rogi , Hajime Komura , Katsuya Nagai
摘要： It is intended to provide a safe composition for preventing or treating obesity or related complications which has an autonomic nervous control effect, in particular, an effect of enhancing sympathetic nervous activity and an effect of promoting energy metabolism. Thus, a medicinal composition, a food or a drink containing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and having an autonomic nervous control effect and an effect of promoting energy metabolism is provided.
摘要翻译： 本发明旨在提供一种用于预防或治疗具有自主神经控制作用的肥胖或相关并发症的安全组合物，特别是增强交感神经活性和促进能量代谢的作用。 因此，含有2,3-二氢-3,5-二羟基-6-甲基-4H-吡喃-4-酮的药物组合物，食品或饮料具有自主神经控制作用和促进能量代谢的作用是 提供。
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9.发明授权Novel polypeptide having an anti-tumor activity and a method of preparation thereof 失效具有抗肿瘤活性的新型多肽及其制备方法
公开(公告)号：US4948875A
公开(公告)日：1990-08-14
申请号：US123316
申请日：1987-11-20
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C12N15/00 , C12N15/70 , C12P21/02 , C12R1/19
CPC分类号： C07K14/525 , C12N15/70
摘要： Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.
摘要翻译： 公开了通过用可能引起严重不良反应的人TNF的氨基酸序列的N-末端替代第31位和32位精氨酸残基而导致副作用降低的趋势的人TNF衍生物， 分别使用天冬酰胺残基和苏氨酸残基，以及利用重组DNA技术制备其的方法。
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10.发明授权Pharmaceutical, food or beverage having inhibitory activity on serotonin transporter 有权对5-羟色胺转运蛋白具有抑制活性的药物，食品或饮料公开(公告)号：US08669267B2
公开(公告)日：2014-03-11
申请号：US13059819
申请日：2009-08-06
申请人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura
发明人： Yoshinori Beppu , Nobuo Tsuruoka , Hajime Komura
IPC分类号： A01N43/42 , A61K31/44 , C07D471/00
CPC分类号： C07D471/04 , A23C9/1307 , A23F5/243 , A23G9/32 , A23L2/02 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/473 , A61K35/74 , C12G3/04 , A23V2200/3204 , A23V2250/032 , A23V2250/606 , A23V2250/5072 , A23V2200/31
摘要： There is provided a pharmaceutical agent, food, or beverage for treating or preventing a disease or condition that can be ameliorated by inhibiting serotonin reuptake, comprising a clinically-effective amount of (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid.
摘要翻译： 提供了用于治疗或预防可以通过抑制血清素再摄取而改善的疾病或病症的药剂，食品或饮料，其包含临床有效量的（1S，3S）-1-甲基-1,2,3 ，4-四氢-β-咔啉-3-羧酸。
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