公开(公告)号：US6071943A

公开(公告)日：2000-06-06

申请号：US200750

申请日：1998-11-30

申请人： Noriaki Shioiri ,  Tadashi Mikami ,  Shinichi Morimoto ,  Kazuo Yamazaki ,  Hiroyuki Naito ,  Junji Okawa ,  Noriyuki Kawamoto ,  Hiroshi Hasegawa ,  Koichi Tachibana ,  Susumu Sato ,  Toshio Yokoyama

发明人： Noriaki Shioiri ,  Tadashi Mikami ,  Shinichi Morimoto ,  Kazuo Yamazaki ,  Hiroyuki Naito ,  Junji Okawa ,  Noriyuki Kawamoto ,  Hiroshi Hasegawa ,  Koichi Tachibana ,  Susumu Sato ,  Toshio Yokoyama

IPC分类号： C07D233/54 ,  C07D233/64 ,  C07D233/70 ,  C07D405/12 ,  A01N43/50

CPC分类号： C07D233/64 ,  C07D405/12

摘要： Disclosed herein are an imidazole derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, or an alkyl, alkoxy or alkoxycarbonyl group, and R.sup.2, R.sup.3 and R.sup.4 are the same or different from one another and are independently a hydrogen or halogen atom, an alkyl, halogenoalkyl, hydroxyl or alkoxy group, or the like, or a salt thereof, and a medicine comprising such a compound. The compound specifically suppresses the production of particular cytokine and is hence useful as an active ingredient for immune function modulators and the like.

摘要翻译： 本文公开了由以下通式（1）表示的咪唑衍生物：其中R1是氢原子或烷基，烷氧基或烷氧基羰基，R2，R3和R4彼此相同或不同，独立地为 氢或卤素原子，烷基，卤代烷基，羟基或烷氧基等，或其盐，以及包含这种化合物的药物。 该化合物特别抑制特定细胞因子的产生，因此可用作免疫功能调节剂等的活性成分。

公开(公告)号：US6046218A

公开(公告)日：2000-04-04

申请号：US952072

申请日：1997-11-17

申请人： Hiroshi Hasegawa ,  Tadashi Mikami ,  Koichi Tachibana ,  Kazuo Yamazaki ,  Noriyuki Kawamoto ,  Noriaki Shioiri ,  Koji Kusano ,  Susumu Sato ,  Hideaki Matsuda ,  Toshio Yokoyama

发明人： Hiroshi Hasegawa ,  Tadashi Mikami ,  Koichi Tachibana ,  Kazuo Yamazaki ,  Noriyuki Kawamoto ,  Noriaki Shioiri ,  Koji Kusano ,  Susumu Sato ,  Hideaki Matsuda ,  Toshio Yokoyama

IPC分类号： C07D213/69 ,  C07D405/06 ,  C07D409/06 ,  A61K31/435 ,  A61K31/44 ,  C07D211/72

CPC分类号： C07D213/69 ,  C07D405/06 ,  C07D409/06 ,  Y10S514/885

摘要： Described is a pyridine derivative represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 individually represent H, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, an alkoxyalkyl group which may have a substituent, a carboxyalkyl group, an alkoxycarbonylalkyl group, an aralkyl group which may have a substituent, a phenacyl group or an acyl group, R.sup.3 represents an alkyl group, a phenyl group which may have a substituent, a heteroaryl group or a cyclic amino group, X represents O or combination of OH and H, or a salt thereof; and a medicament, such as cytokine production suppressant, comprising the derivative or salt thereof as an effective ingredient. The invention compound has potential, highly specific and highly safe immunoregulating capacity so that it can suppress the excessive production of a specific cytokine in various diseases related to the immune system.

摘要翻译： PCT No.PCT / JP97 / 00712 Sec。 371日期：1997年11月17日 102（e）日期1997年11月17日PCT 1997年3月7日PCT公布。 出版物WO97 / 33870 PCT 日期：1997年9月18日是由下式（1）表示的吡啶衍生物：其中R1和R2分别表示H，烷基，环烷基，羟烷基，可具有取代基的烷氧基烷基，羧基烷基 烷氧基羰基烷基，可具有取代基的芳烷基，苯甲酰甲酰基或酰基，R3表示烷基，可具有取代基的苯基，杂芳基或环状氨基，X表示O 或OH和H的组合或其盐; 以及包含其衍生物或其盐作为有效成分的药物，例如细胞因子产生抑制剂。 本发明化合物具有潜在的，高度特异性和高度安全的免疫调节能力，从而可以抑制与免疫系统相关的各种疾病中特定细胞因子的过量产生。

公开(公告)号：US5935977A

公开(公告)日：1999-08-10

申请号：US68986

申请日：1998-05-26

申请人： Kazuo Yamazaki ,  Yoichiro Ogawa ,  Hidehiko Kohya ,  Tadashi Mikami ,  Noriyuki Kawamoto ,  Noriaki Shioiri ,  Hiroshi Hasegawa ,  Susumu Sato

发明人： Kazuo Yamazaki ,  Yoichiro Ogawa ,  Hidehiko Kohya ,  Tadashi Mikami ,  Noriyuki Kawamoto ,  Noriaki Shioiri ,  Hiroshi Hasegawa ,  Susumu Sato

IPC分类号： C07D213/69 ,  C07D401/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D417/14 ,  A61K31/44

CPC分类号： C07D213/69 ,  C07D401/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D417/14

摘要： The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): ##STR1## (wherein R.sup.1 represents a hydrogen atom, an alkyl group, etc., R.sup.2 represents an alkyl group; one of R.sup.3 and R.sup.4, which are different from each other, represents a hydrogen atom and the other represents a nitrile group, R.sup.5 represents an aryl group or a heteroaryl group, X represents an oxygen atom, etc., and one of Q.sup.1, Q.sup.2, and Q.sup.3 represents a nitrogen atom and the other two represent CH); a salt of the derivative; and a drug containing the derivative or salt as the active ingredient. Due to strong PDE inhibitory action and TNF-.alpha. production inhibitory action, the derivative, salt, and drug are useful for the prevention and treatment of a wide variety of inflammatory diseases and autoimmune diseases.

摘要翻译： PCT No.PCT / JP97 / 03354 Sec。 371日期：1998年5月26日 102（e）日期1998年5月26日PCT 1997年9月22日PCT公布。 公开号WO98 / 13348 日期：1998年4月2日本发明涉及由下式（1）表示的取代乙烯基吡啶衍生物：其中，R1表示氢原子，烷基等，R2表示烷基，R3和R4之一， 彼此不同，表示氢原子，另一个表示腈基，R 5表示芳基或杂芳基，X表示氧原子等，Q 1，Q 2和Q 3中的一个表示氮 原子，另外两个表示CH）; 衍生物的盐; 和含有衍生物或盐的活性成分的药物。 由于强烈的PDE抑制作用和TNF-α产生抑制作用，衍生物，盐和药物可用于预防和治疗各种炎性疾病和自身免疫性疾病。

公开(公告)号：US09093350B2

公开(公告)日：2015-07-28

申请号：US13808865

申请日：2011-07-04

申请人： Nobuyuki Endo ,  Tetsuya Itano ,  Kazuo Yamazaki ,  Kyouhei Watanabe ,  Junji Iwata

发明人： Nobuyuki Endo ,  Tetsuya Itano ,  Kazuo Yamazaki ,  Kyouhei Watanabe ,  Junji Iwata

IPC分类号： H01L27/00 ,  H01L27/146 ,  H01L31/04

CPC分类号： H01L27/1469 ,  H01L27/14634 ,  H01L27/14636 ,  H01L27/1464 ,  H01L27/14687 ,  H01L27/14689 ,  H01L31/04 ,  H01L2224/05655

摘要： A member for a solid-state image pickup device having a bonding plane with no gaps and a method for manufacturing the same are provided. The manufacturing method includes the steps of providing a first substrate provided with a photoelectric converter on its primary face and a first wiring structure, providing a second substrate provided with a part of a peripheral circuit on its primary face and a second wiring structure, and performing bonding so that the first substrate, the first wiring structure, the second wiring structure, and the second substrate are disposed in this order. In addition, at least one of an upper face of the first wiring structure and an upper face of the second wiring structure has a concave portion, and a conductive material forms a bottom face of the concave portion.

摘要翻译： 提供具有无间隙的接合面的固态摄像装置的构件及其制造方法。 该制造方法包括以下步骤：在其主面上设置设置有光电转换器的第一基板和第一布线结构，在其主面上设置设置有周边电路的一部分的第二基板和第二布线结构， 使得第一基板，第一布线结构，第二布线结构和第二基板按顺序布置。 此外，第一布线结构的上表面和第二布线结构的上表面中的至少一个具有凹部，并且导电材料形成凹部的底面。

公开(公告)号：US08928143B2

公开(公告)日：2015-01-06

申请号：US13244369

申请日：2011-09-24

申请人： Kazuo Yamazaki

发明人： Kazuo Yamazaki

IPC分类号： H01L23/48 ,  H01L23/52 ,  H01L29/40 ,  H01L27/108 ,  H01L21/768 ,  H01L23/485

CPC分类号： H01L21/76831 ,  H01L21/76883 ,  H01L23/485 ,  H01L27/10814 ,  H01L27/10885 ,  H01L2924/0002 ,  H01L2924/00

摘要： To prevent two contacts that have different heights, share at least one interlayer insulating film and are disposed close to each other from being short-circuited to each other due to misalignment thereof, a semiconductor device according to the invention has a recess in an interlayer insulating film in which a first contact having a lower height, the recess being formed by the upper surface of the first contact, and a silicon nitride sidewall is formed in the recess to extend from the upper surface of the first contact and along the side surface of the recess.

摘要翻译： 为了防止具有不同高度的两个触点，共享至少一个层间绝缘膜并且由于其不对准而彼此靠近彼此设置，根据本发明的半导体器件具有在层间绝缘中的凹部 其中具有较低高度的第一接触件，由第一接触件的上表面形成的凹部和氮化硅侧壁形成在凹部中，以从第一接触件的上表面延伸并沿着第一接触件的侧表面 凹槽

公开(公告)号：US08920080B2

公开(公告)日：2014-12-30

申请号：US13070870

申请日：2011-03-24

申请人： Kazuo Yamazaki ,  Toru Fujimori

发明人： Kazuo Yamazaki ,  Toru Fujimori

IPC分类号： B23C1/06 ,  B23Q17/22 ,  G05B19/402 ,  G05B19/404 ,  B23C1/00

CPC分类号： G05B19/404 ,  B23C1/002 ,  B23C1/06 ,  B23C2250/00 ,  B23C2260/48 ,  B23C2260/76 ,  B23Q17/22 ,  B23Q17/2233 ,  B23Q17/225 ,  B23Q2717/006 ,  G05B2219/37024 ,  G05B2219/42318 ,  Y10T408/175 ,  Y10T409/300896 ,  Y10T409/306888 ,  Y10T409/306944 ,  Y10T409/308064 ,  Y10T409/308288

摘要： A machine tool 1 comprises a bed 11, a column 12, a spindle head 15, a spindle 16, a saddle 17, a table 18, a feed mechanism for moving the spindle head 15, the saddle 17 and the table 18 in Z-axis, Y-axis and X-axis directions respectively, a position detector for detecting the positions of the spindle head 15, saddle 17 and table 18, a controller for feedback controlling the feed mechanism, a position detector 51 for detecting the position of the spindle head 15, a position detector 54 for detecting the position of the spindle head 15, a position detector 57 for detecting the position of the table 18, and a measurement frame 50 which is configured with a different member from the bed 11 and the column 12 and on which readers 53, 56, 59 of the position detectors 51, 54, 57 are disposed.

摘要翻译： 机床1包括床11，柱12，主轴头15，主轴16，鞍座17，工作台18，用于使主轴头15，鞍座17和工作台18在Z轴方向上移动的进给机构， 轴，Y轴和X轴方向的位置检测器，用于检测主轴头15，鞍座17和工作台18的位置的位置检测器，用于反馈控制进给机构的控制器，位置检测器51， 主轴头15，用于检测主轴头15的位置的位置检测器54，用于检测工作台18的位置的位置检测器57以及配置有与床11和列的不同构件的测量框架50 位置检测器51,54,57的读取器53,56,59设置在其上。

公开(公告)号：US08325260B2

公开(公告)日：2012-12-04

申请号：US12628271

申请日：2009-12-01

申请人： Kazuo Yamazaki ,  Hiroki Hiyama ,  Masaaki Iwane

发明人： Kazuo Yamazaki ,  Hiroki Hiyama ,  Masaaki Iwane

IPC分类号： H04N3/14 ,  H04N5/335

CPC分类号： H04N5/3742

摘要： It is an object of the present invention to provide a solid-state imaging apparatus that outputs digital signals at high speed. A solid-state imaging apparatus is provided that includes plural analog-to-digital converters that convert analog signals obtained by photoelectric conversion into digital signals, plural digital memories that store the digital signals converted by the analog-to-digital converters, plural block digital output lines that are provided to correspond to blocks of the plural digital memories and to which the digital signals stored in the plural digital memories included in the blocks are output, a common digital output line that outputs the digital signals output from the plural block digital output lines, buffer circuits that buffer the digital signals output from the block digital output lines, and block selecting units that can switch the block digital output lines electrically connected to the common digital output line.

摘要翻译： 本发明的目的是提供一种以高速输出数字信号的固态成像装置。 提供了一种固态成像装置，其包括将通过光电转换获得的模拟信号转换为数字信号的多个模数转换器，存储由模数转换器转换的数字信号的多个数字存储器，多个数字数字 输出对应于多个数字存储器中的块并被存储在包含在块中的多个数字存储器中的数字信号的输出线，输出从多个数字输出端输出的数字信号的公共数字输出线 用于缓冲从块数字输出线输出的数字信号的缓冲电路，以及可以切换电连接到公共数字输出线的块数字输出线的块选择单元。

公开(公告)号：US20120013778A1

公开(公告)日：2012-01-19

申请号：US13243168

申请日：2011-09-23

申请人： Kazuhiro Sonoda ,  Kazuo Yamazaki ,  Shintaro Takenaka

发明人： Kazuhiro Sonoda ,  Kazuo Yamazaki ,  Shintaro Takenaka

IPC分类号： H04N5/335

CPC分类号： H04N5/37455 ,  H04N5/3456 ,  H04N9/04511

摘要： When a horizontal skipping operation is performed in a solid-state imaging apparatus that includes an A/D converting circuit in each column and that applies an arithmetic operation process to a digitalized signal and an arithmetic operation is performed with signals held by a plurality of register circuits, A/D converters and register circuits in columns in which signals are skipped, or not read out, are not involved in the operations. A more consideration is needed in terms of the use efficiency of circuits. A unit for connecting a register circuit of a certain column and a register circuit of a different column is arranged.

摘要翻译： 当在包括每列中的A / D转换电路的固态成像装置中执行水平跳过操作并且对数字化信号应用算术运算处理并且利用由多个寄存器保持的信号执行算术运算时 电路，A / D转换器和信号被跳过或未读出的列中的寄存器电路不涉及操作。 在电路的使用效率方面需要更多的考虑。 用于连接特定列的寄存器电路和不同列的寄存器电路的单元被布置。

公开(公告)号：US20120012910A1

公开(公告)日：2012-01-19

申请号：US13244369

申请日：2011-09-24

申请人： Kazuo Yamazaki

发明人： Kazuo Yamazaki

IPC分类号： H01L27/108

CPC分类号： H01L21/76831 ,  H01L21/76883 ,  H01L23/485 ,  H01L27/10814 ,  H01L27/10885 ,  H01L2924/0002 ,  H01L2924/00

摘要： To prevent two contacts that have different heights, share at least one interlayer insulating film and are disposed close to each other from being short-circuited to each other due to misalignment thereof, a semiconductor device according to the invention has a recess in an interlayer insulating film in which a first contact having a lower height, the recess being formed by the upper surface of the first contact, and a silicon nitride sidewall is formed in the recess to extend from the upper surface of the first contact and along the side surface of the recess.

摘要翻译： 为了防止具有不同高度的两个触点，共享至少一个层间绝缘膜并且由于其不对准而彼此靠近彼此设置，根据本发明的半导体器件具有在层间绝缘中的凹部 其中具有较低高度的第一接触件，由第一接触件的上表面形成的凹部和氮化硅侧壁形成在凹部中，以从第一接触件的上表面延伸并沿着第一接触件的侧表面 凹槽

公开(公告)号：US08053360B2

公开(公告)日：2011-11-08

申请号：US12356844

申请日：2009-01-21

申请人： Kazuo Yamazaki

发明人： Kazuo Yamazaki

IPC分类号： H01L21/4763

CPC分类号： H01L21/76831 ,  H01L21/76883 ,  H01L23/485 ,  H01L27/10814 ,  H01L27/10885 ,  H01L2924/0002 ,  H01L2924/00

摘要： To prevent two contacts that have different heights, share at least one interlayer insulating film and are disposed close to each other from being short-circuited to each other due to misalignment thereof, a semiconductor device according to the invention has a recess in an interlayer insulating film in which a first contact hiving a lower height, the recess being formed by the upper surface of the first contact, and a silicon nitride sidewall is formed in the recess to extend from the upper surface of the first contact and along the side surface of the recess.

摘要翻译： 为了防止具有不同高度的两个触点，共享至少一个层间绝缘膜并且由于其不对准而彼此靠近彼此设置，根据本发明的半导体器件具有在层间绝缘中的凹部 其中第一接触件具有较低的高度，所述凹部由所述第一接触件的上表面形成，并且在所述凹部中形成氮化硅侧壁，以从所述第一接触件的上表面延伸并沿着所述第一接触件的侧表面 凹槽