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    PRINTED STRETCHABLE STRAIN SENSOR
    2.
    发明申请
    PRINTED STRETCHABLE STRAIN SENSOR 审中-公开
    印刷可拉伸应变传感器

    公开(公告)号：US20160290880A1

    公开(公告)日：2016-10-06

    申请号：US15036937

    申请日：2014-11-17

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Jennifer A. Lewis ,  Joseph T. Muth ,  Daniel M. Vogt ,  Ryan L. Truby ,  Yigit Menguc ,  David B. Kolesky ,  Robert J. Wood

    IPC: G01L1/22

    CPC classification number: G01L1/2287 ,  G01L1/18 ,  G01L1/20 ,  G06F3/014

    Abstract: A printed stretchable strain sensor comprises a seamless elastomeric body and a strain-sensitive conductive structure embedded in the seamless elastomeric body. The strain-sensitive conductive structure comprises one or more conductive filaments arranged in a continuous pattern. A method of printing a stretchable strain sensor comprises depositing one or more conductive filaments in a predetermined continuous pattern into or onto a support matrix. After the depositing, the support matrix is cured to embed a strain-sensitive conductive structure in a seamless elastomeric body.

    Abstract translation: 印刷的可拉伸应变传感器包括无缝弹性体和嵌入无缝弹性体中的应变敏感导电结构。 应变敏感导电结构包括以连续图案布置的一个或多个导电细丝。 打印可拉伸应变传感器的方法包括将预定连续图案中的一个或多个导电细丝沉积到载体矩阵中或载体上。 在沉积之后，支撑基体被固化以将应变敏感导电结构嵌入到无缝弹性体中。

    METHOD OF PRINTING A TISSUE CONSTRUCT WITH EMBEDDED VASCULATURE
    4.
    发明申请
    METHOD OF PRINTING A TISSUE CONSTRUCT WITH EMBEDDED VASCULATURE 审中-公开
    打印组织结构与嵌入式血管的方法

    公开(公告)号：US20160287756A1

    公开(公告)日：2016-10-06

    申请号：US15146613

    申请日：2014-11-04

    Applicant: President and Fellows of Harvard College

    Inventor： Jennifer A. Lewis ,  David B. Kolesky ,  Mark A. Skylar-Scott ,  Kimberly A. Homan ,  Ryan L. Truby ,  Amelia Sydney Gladman

    IPC: A61L27/50 ,  A61L27/22 ,  A61F2/06 ,  B29C67/00 ,  B33Y10/00 ,  B33Y80/00 ,  A61L27/38 ,  A61L27/36

    CPC classification number: A61L27/507 ,  A61F2/06 ,  A61F2/105 ,  A61F2240/002 ,  A61L27/222 ,  A61L27/225 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3826 ,  A61L2430/34 ,  B29C64/106 ,  B29C64/40 ,  B33Y10/00 ,  B33Y80/00 ,  C12M33/00

    Abstract: A printed tissue construct comprises one or more tissue patterns, where each tissue pattern comprises a plurality of viable cells of one or more predetermined cell types. A network of vascular channels interpenetrates the one or more tissue patterns. An extracellular matrix composition at least partially surrounds the one or more tissue patterns and the network of vascular channels. A method of printing a tissue construct with embedded vasculature comprises depositing one or more cell-laden filaments, each comprising a plurality of viable cells, on a substrate to form one or more tissue patterns. Each of the one or more tissue patterns comprises one or more predetermined cell types. One or more sacrificial filaments, each comprising a fugitive ink, are deposited on the substrate to form a vascular pattern interpenetrating the one or more tissue patterns. The vascular pattern and the one or more tissue patterns are at least partially surrounded with an extracellular matrix composition. The fugitive ink is then removed to create vascular channels in the extracellular matrix composition, thereby forming an interpenetrating vascular network in a tissue construct.

    Abstract translation: 印刷的组织结构包括一个或多个组织图案，其中每个组织图案包括一个或多个预定细胞类型的多个活细胞。 血管通道网络穿过一个或多个组织模式。 细胞外基质组合物至少部分地包围一个或多个组织模式和血管通道的网络。 印刷具有嵌入脉管系统的组织构建体的方法包括在衬底上沉积一个或多个包含多个活细胞的细胞细胞丝，以形成一个或多个组织图案。 一个或多个组织图案中的每一个包括一个或多个预定的细胞类型。 一个或多个牺牲丝，每个包括一种短效油墨，沉积在该基底上以形成一个或多个组织图案互穿的血管图案。 血管图案和一个或多个组织图案至少部分地被细胞外基质组合物包围。 然后除去逸散性油墨以在细胞外基质组合物中产生血管通道，从而在组织构建体中形成互穿血管网络。

    Method of printing a tissue construct with embedded vasculature
    6.
    发明授权
    Method of printing a tissue construct with embedded vasculature 有权

    公开(公告)号：US10117968B2

    公开(公告)日：2018-11-06

    申请号：US15146613

    申请日：2014-11-04

    Applicant: President and Fellows of Harvard College

    Inventor： Jennifer A. Lewis ,  David B. Kolesky ,  Mark A. Skylar-Scott ,  Kimberly A. Homan ,  Ryan L. Truby ,  Amelia Sydney Gladman

    IPC: A61L27/50 ,  B29C64/40 ,  B29C64/106 ,  A61L27/38 ,  B33Y10/00 ,  B33Y80/00 ,  A61F2/06 ,  A61L27/22 ,  A61F2/10 ,  A61L27/36 ,  C12M1/26

    Abstract: A printed tissue construct comprises one or more tissue patterns, where each tissue pattern comprises a plurality of viable cells of one or more predetermined cell types. A network of vascular channels interpenetrates the one or more tissue patterns. An extracellular matrix composition at least partially surrounds the one or more tissue patterns and the network of vascular channels. A method of printing a tissue construct with embedded vasculature comprises depositing one or more cell-laden filaments, each comprising a plurality of viable cells, on a substrate to form one or more tissue patterns. Each of the one or more tissue patterns comprises one or more predetermined cell types. One or more sacrificial filaments, each comprising a fugitive ink, are deposited on the substrate to form a vascular pattern interpenetrating the one or more tissue patterns. The vascular pattern and the one or more tissue patterns are at least partially surrounded with an extracellular matrix composition. The fugitive ink is then removed to create vascular channels in the extracellular matrix composition, thereby forming an interpenetrating vascular network in a tissue construct.

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