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    ILEAL ELECTRICAL STIMULATION
    4.
    发明申请
    ILEAL ELECTRICAL STIMULATION 有权
    ILEAL电刺激

    公开(公告)号：US20110066208A1

    公开(公告)日：2011-03-17

    申请号：US12865292

    申请日：2009-01-30

    申请人： Pankaj Pasricha ,  Jiande Chen

    发明人： Pankaj Pasricha ,  Jiande Chen

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36007

    摘要： The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.

    摘要翻译： 本公开是在需要的个体中治疗肥胖症的方法，包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在 部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说，在脉冲串中提供电刺激。 此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜，内窥镜或外科手段放置。

    Gastrointestinal electrical stimulation for the treatment of pacreatitis
    6.
    发明授权
    Gastrointestinal electrical stimulation for the treatment of pacreatitis 有权
    胃肠电刺激治疗胰腺炎

    公开(公告)号：US08326427B2

    公开(公告)日：2012-12-04

    申请号：US12836377

    申请日：2010-07-14

    申请人： Pankaj Pasricha ,  Jlande Chen

    发明人： Pankaj Pasricha ,  Jlande Chen

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

    摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

    摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。

    GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS
    7.
    发明申请
    GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS 有权
    用于治疗胰腺炎的胃肠电刺激

    公开(公告)号：US20110015695A1

    公开(公告)日：2011-01-20

    申请号：US12836377

    申请日：2010-07-14

    申请人： Pankaj Pasricha ,  Jiande Chen

    发明人： Pankaj Pasricha ,  Jiande Chen

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

    摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

    摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。

    Compositions and methods for treating and diagnosing irritable bowel syndrome
    8.
    发明申请
    Compositions and methods for treating and diagnosing irritable bowel syndrome 有权
    用于治疗和诊断肠易激综合征的组合物和方法

    公开(公告)号：US20050130189A1

    公开(公告)日：2005-06-16

    申请号：US10923035

    申请日：2004-08-23

    申请人： Pankaj Pasricha ,  Mohan Shenoy ,  John Winston

    发明人： Pankaj Pasricha ,  Mohan Shenoy ,  John Winston

    IPC分类号： A61K20060101 ,  A61K38/17 ,  A61K48/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2800/065

    摘要： Compositions and methods for diagnosing and treating CVH and CVH-associated disorders are disclosed. Genes differentially expressed in CVH tissues relative to normal tissues are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used as markers of CVH. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products.

    摘要翻译： 公开了用于诊断和治疗CVH和CVH相关疾病的组合物和方法。 鉴定出相对于正常组织在CVH组织中差异表达的基因。 可以将基因和基因产物（即从该基因转录的多核苷酸和由该基因编码的多肽）用作CVH的标记物。 基因和基因产物也可以用于筛选调节基因表达或基因产物活性的试剂。

    COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING IRRITABLE BOWEL SYNDROME
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING IRRITABLE BOWEL SYNDROME 审中-公开
    用于治疗和诊断有用的牙刷综合征的组合物和方法

    公开(公告)号：US20120115746A1

    公开(公告)日：2012-05-10

    申请号：US13311492

    申请日：2011-12-05

    申请人： Pankaj Pasricha ,  Mohan Shenoy ,  John Winston

    发明人： Pankaj Pasricha ,  Mohan Shenoy ,  John Winston

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  G01N33/566 ,  C07K14/435 ,  C07H21/04

    CPC分类号： G01N33/6893 ,  G01N2800/065

    摘要： Compositions and methods for diagnosing and treating CVH and CVH-associated disorders are disclosed. Genes differentially expressed in CVH tissues relative to normal tissues are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used as markers of CVH. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products.

    摘要翻译： 公开了用于诊断和治疗CVH和CVH相关疾病的组合物和方法。 鉴定出相对于正常组织在CVH组织中差异表达的基因。 可以将基因和基因产物（即从该基因转录的多核苷酸和由该基因编码的多肽）用作CVH的标记物。 基因和基因产物也可用于筛选调节基因表达或基因产物活性的试剂。