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公开(公告)号：US07438856B2
公开(公告)日：2008-10-21
申请号：US10603339
申请日：2003-06-24
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译： 本发明的实施例涉及微流体装置。 在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。 转印分离通道终止于放电孔。
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公开(公告)号：US20090028755A1
公开(公告)日：2009-01-29
申请号：US12210389
申请日：2008-09-15
IPC分类号： B01J19/00
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译： 本发明的实施例涉及微流体装置。 在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。 转印分离通道终止于放电孔。
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公开(公告)号：US06730516B2
公开(公告)日：2004-05-04
申请号：US10208381
申请日：2002-07-29
IPC分类号： G01N3500
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
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公开(公告)号：US06454924B2
公开(公告)日：2002-09-24
申请号：US09792488
申请日：2001-02-23
IPC分类号： C02F140
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译： 本发明的实施例涉及微流体装置。 在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。 转印分离通道终止于放电孔。
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公开(公告)号：US06720157B2
公开(公告)日：2004-04-13
申请号：US09792335
申请日：2001-02-23
IPC分类号： G01N3353
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A chip is disclosed. The chip includes a base including a non-sample surface and at least one structure includes a pillar. Each structure includes a sample surface that is elevated with respect to the non-sample surface and each structure may be adapted to receive a sample.
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公开(公告)号：US20110086779A1
公开(公告)日：2011-04-14
申请号：US12950698
申请日：2010-11-19
申请人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
发明人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
CPC分类号： G01N33/6845 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
摘要翻译： 提供了可用于同时检测生物体中细胞或细胞群体的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。 特别描述了各种抗体阵列。 还公开了制备和使用蛋白质捕获剂的阵列的方法。 本发明阵列对于各种蛋白质组学应用特别有用，包括评估细胞中蛋白质表达和修饰的模式。
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公开(公告)号：US20090047695A1
公开(公告)日：2009-02-19
申请号：US12173515
申请日：2008-07-15
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： C12Q1/48 , G01N33/68 , G01N33/50 , G01N33/543
CPC分类号： B82Y30/00 , Y10S435/805 , Y10S435/81 , Y10T436/143333
摘要： Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, nucleic acids, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These devices are useful in high-throughput drug screening and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译： 提供了使用微型微加工装置并行，体外筛选生物分子活性的方法和装置。 可以固定在本发明装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，核酸，多糖，磷脂和相关的非天然聚合物。 这些装置在高通量药物筛选和临床诊断中是有用的，并且优选用于相关蛋白家族的并行筛选。
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公开(公告)号：US06682942B1
公开(公告)日：2004-01-27
申请号：US09570589
申请日：2000-05-12
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y30/00
摘要： Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices employed in the method of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These methods are useful in drug development, functional proteomics studies and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译： 提供了使用微型微型加工装置平行体外筛选生物分子活性的方法。 固定在本发明方法中使用的装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，多核苷酸，多糖，磷脂和相关的非天然聚合物。 这些方法可用于药物开发，功能蛋白质组学研究和临床诊断，并且优选用于相关蛋白家族的平行筛选。
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公开(公告)号：US06475808B1
公开(公告)日：2002-11-05
申请号：US09353215
申请日：1999-07-14
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： G01N33/6845 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thinfilms on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.
摘要翻译： 提供了用于平行，体外筛选生物分子活性的蛋白质阵列。 还公开了使用蛋白质阵列的方法。 在阵列上，多个不同的蛋白质，例如单个蛋白质家族的不同成员，被固定在基底表面上的一个或多个有机薄膜上。 蛋白质阵列特别适用于药物开发，蛋白质组学和临床诊断。
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公开(公告)号：US06780582B1
公开(公告)日：2004-08-24
申请号：US09574692
申请日：2000-05-17
申请人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
发明人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y5/00 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y30/00 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
摘要翻译： 提供了可用于同时检测生物体中细胞或细胞群的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。 特别描述了各种抗体阵列。 还公开了制备和使用蛋白质捕获剂的阵列的方法。 本发明阵列对于各种蛋白质组学应用特别有用，包括评估细胞中蛋白质表达和修饰的模式。
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