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    Valve block
    3.
    发明授权
    Valve block 失效
    阀块

    公开(公告)号：US5653259A

    公开(公告)日：1997-08-05

    申请号：US539496

    申请日：1995-10-06

    Applicant: Paul O. Ramstad

    Inventor： Paul O. Ramstad

    IPC: B01J4/02 ,  B01J19/00 ,  C40B60/14 ,  F16K7/14 ,  F16K27/00 ,  F16K31/06 ,  F16K7/12

    CPC classification number: F16K31/06 ,  B01J19/0046 ,  B01J4/02 ,  F16K27/003 ,  F16K7/14 ,  B01J2219/00389 ,  B01J2219/00412 ,  C40B60/14 ,  Y10T137/4259 ,  Y10T137/87684 ,  Y10T137/87885

    Abstract: A manifold block and valving system using the manifold block are provided, which are used for conducting chemical reagents, solvents, and other fluids. The manifold block includes a "straight-through" common passage in fluid connection with several entry ports, including also a number of projections in the common passage in the vicinity of the entry ports. These projections partially obstruct the fluid flow, causing a turbulence that provides a washing action in those port regions. The manifold may be constructed of a photosensitive glass ceramic such as Fotoceram.TM. which consists of a number of layers which have been processed to form the manifold block, or of other suitable materials such as silicon.

    Abstract translation: 提供使用歧管块的歧管块和阀门系统，用于导入化学试剂，溶剂和其它流体。 歧管块包括与多个入口端口流体连接的“直通”公共通道，包括在入口端口附近的公共通道中的多个突起。 这些突起部分地阻碍流体流动，导致在这些端口区域中提供洗涤动作的湍流。 歧管可以由诸如Fotoceram TM的感光玻璃陶瓷构成，其由已经被处理以形成歧管块的多个层或其它合适的材料例如硅组成。

    Automated polypeptide synthesis process
    7.
    发明授权
    Automated polypeptide synthesis process 失效
    自动多肽合成过程

    公开(公告)号：US4816513A

    公开(公告)日：1989-03-28

    申请号：US53324

    申请日：1987-05-22

    Applicant: John Bridgham ,  Timothy G. Geiser ,  Michael W. Hunkapiller ,  Stephen B. H. Kent ,  Mark P. Marriott ,  Paul O. Ramstad ,  Eric S. Nordman

    Inventor： John Bridgham ,  Timothy G. Geiser ,  Michael W. Hunkapiller ,  Stephen B. H. Kent ,  Mark P. Marriott ,  Paul O. Ramstad ,  Eric S. Nordman

    IPC: C07K1/00 ,  B01J19/00 ,  C07K1/04 ,  C40B40/10 ,  C40B60/14 ,  C08L89/00 ,  C07C103/52

    CPC classification number: C07K1/045 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00389 ,  B01J2219/00484 ,  B01J2219/00488 ,  B01J2219/0049 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14

    Abstract: An apparatus is provided for automatically constructing a polypeptide of high purity, up to 50 amino acids in length, using only single couplings. The apparatus includes an activation system for receiving protected amino acids, one kind at a time, having a common vessel (an activator vessel) in which to activate each of the amino acids. Also included is a reaction vessel for containing a resin used in solid-phase peptide synthesis for attaching a peptide chain thereto. A transfer system is also provided, which operates under control of a computer, to transfer the activated species from the activation system to the reaction vessel and to transfer amino acids, reagents, gases, and solvents from one part of the apparatus to another. The activator system also includes a temperature controlled concentrator vessel in which an activator solvent is replaced by a coupling solvent to enhance the coupling of the activated species to the peptide chain in the reaction vessel. Also included in the synthesizer system is a vortexer for affecting total washing of materials in the reaction vessel and the reaction vessel itself, an automated peptide resin sampling system, and an autodelivery system for providing individual containers of amino acid to the synthesizer in the order desired in the peptide sequence. A liquid sensor system is also included to monitor transitions between gases and liquids in specific tubes in the synthesizer in order to provide input signals to the computer system for control purposes. The computer system software which controls the operation of the synthesizer is organized according to a series of menus which allows the user of the system to select individual cycles of operation for each vessel in the synthesizer. In addition, an algorithm has been developed which provides for optimum efficiency in the production of a peptide for any given selection of cycles.

    Abstract translation: 提供了一种用于仅使用单个耦合自动构建高纯度多达50个氨基酸长度的多肽的装置。 该装置包括用于一次接收受保护的氨基酸的激活系统，其具有在其中激活每个氨基酸的共同血管（活化剂容器）。 还包括用于含有固相肽合成中用于连接肽链的树脂的反应容器。 还提供了在计算机控制下操作的转移系统，以将活化物质从活化系统转移到反应容器中，并将氨基酸，试剂，气体和溶剂从设备的一部分转移到另一部分。 活化剂体系还包括温度控制的浓缩容器，其中活化剂溶剂被偶联溶剂代替以增强活化物质与反应容器中的肽链的偶联。 还包括在合成器系统中的是用于影响反应容器和反应容器本身中的材料的全部洗涤的涡流器，自动化肽树脂取样系统和用于按合适的顺序向合成器提供单个氨基酸容器的自动输送系统 在肽序列中。 还包括液体传感器系统以监测合成器中特定管中的气体和液体之间的转换，以便为控制目的向计算机系统提供输入信号。 控制合成器操作的计算机系统软件根据一系列菜单进行组织，这些菜单允许系统的用户为合成器中的每个容器选择各个操作周期。 此外，已经开发了一种算法，其提供用于任何给定选择周期的肽的生产的最佳效率。

    Petal-array support for use with microplates
    9.
    发明授权
    Petal-array support for use with microplates 失效
    花瓣阵列支持与微孔板一起使用

    公开(公告)号：US06632660B2

    公开(公告)日：2003-10-14

    申请号：US10038974

    申请日：2002-01-04

    Applicant: Paul O. Ramstad

    Inventor： Paul O. Ramstad

    IPC: C12M122

    CPC classification number: B01L3/50853 ,  B01L2300/046 ,  B01L2300/0636 ,  B01L2300/0829

    Abstract: The present invention provides, among other things, supports upon which one or more species can be adsorbed, captured, or immobilized for biochemical procedures. In various embodiments, the supports include a plurality of deformable petal-like members that provide binding sites for biochemical species. The invention provides an apparatus and method for the ready insertion of the petal-like members into respective wells of a multi-well microplate (e.g., a standard-format 96- or 384-well plate).

    Abstract translation: 本发明尤其提供了一种或多种物质可以被吸附，捕获或固定用于生化过程的载体。 在各种实施方案中，支持物包括提供用于生物化学物质的结合位点的多个可变形花瓣状构件。 本发明提供了一种用于将花瓣状构件准备好插入多孔微孔板（例如，标准格式96-或384-孔板）的相应孔中的装置和方法。

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