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    Gel Formulations and Uses Thereof
    2.
    发明申请
    Gel Formulations and Uses Thereof 有权
    凝胶制剂及其用途

    公开(公告)号：US20080182287A1

    公开(公告)日：2008-07-31

    申请号：US11571559

    申请日：2005-07-01

    申请人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

    发明人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

    IPC分类号： C12Q1/02 ,  G01N33/543 ,  B01J19/00 ,  C40B40/00

    CPC分类号： G01N33/5005 ,  A61L31/145 ,  C11D3/3707 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6458 ,  G01N33/545 ,  Y02A50/58

    摘要： The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.

    摘要翻译： 本发明提供包含嵌段聚合物作为载体基质的组合物在微粒例如细胞和荧光珠的操作，加工或分析中的用途。 在优选的实施方案中，组合物显示凝胶 - 溶胶热可逆性，胶凝条件下的胶束形成，光学相容性，可控表面活性剂性质，分子筛分性质和生物相容性。 本发明的另外方面提供（a）载体基质组合物，其包含用于操作，加工或分析颗粒的嵌段聚合物，荧光珠和/或染料，（b）涂覆在载体基质组合物中的多室板， （c）制作该产品的成套工具。

    Gel Formulations and Uses Thereof
    3.
    发明申请
    Gel Formulations and Uses Thereof 有权
    凝胶制剂及其用途

    公开(公告)号：US20120219470A1

    公开(公告)日：2012-08-30

    申请号：US12749056

    申请日：2010-03-29

    申请人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

    发明人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

    IPC分类号： B01L3/00

    CPC分类号： G01N33/5005 ,  A61L31/145 ,  C11D3/3707 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6458 ,  G01N33/545 ,  Y02A50/58

    摘要： The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.

    摘要翻译： 本发明提供包含嵌段聚合物作为载体基质的组合物在微粒例如细胞和荧光珠的操作，加工或分析中的用途。 在优选的实施方案中，组合物显示凝胶 - 溶胶热可逆性，胶凝条件下的胶束形成，光学相容性，可控表面活性剂性质，分子筛分性质和生物相容性。 本发明的另外方面提供（a）载体基质组合物，其包含用于操作，加工或分析颗粒的嵌段聚合物，荧光珠和/或染料，（b）涂覆在载体基质组合物中的多室板， （c）制作该产品的成套工具。

    Analyzing cells immobilized in block copolymers
    4.
    发明授权
    Analyzing cells immobilized in block copolymers 有权
    分析固定在嵌段共聚物中的细胞

    公开(公告)号：US07723085B2

    公开(公告)日：2010-05-25

    申请号：US11571559

    申请日：2005-07-01

    申请人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

    发明人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

    IPC分类号： C12N11/02

    CPC分类号： G01N33/5005 ,  A61L31/145 ,  C11D3/3707 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6458 ,  G01N33/545 ,  Y02A50/58

    摘要： The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.

    摘要翻译： 本发明提供包含嵌段聚合物作为载体基质的组合物在微粒例如细胞和荧光珠的操作，加工或分析中的用途。 在优选的实施方案中，组合物显示凝胶 - 溶胶热可逆性，胶凝条件下的胶束形成，光学相容性，可控表面活性剂性质，分子筛分性质和生物相容性。 本发明的另外方面提供（a）载体基质组合物，其包含用于操作，加工或分析颗粒的嵌段聚合物，荧光珠和/或染料，（b）涂覆在载体基质组合物中的多室板， （c）制作该产品的成套工具。

    Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone
    5.
    发明申请
    Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone 审中-公开
    通过烷基化蒽醌对细胞周期进程的有效细胞毒性和抑制作用

    公开(公告)号：US20070208085A1

    公开(公告)日：2007-09-06

    申请号：US11655043

    申请日：2007-01-17

    申请人： Agamemnon Epenetos ,  Klaus Pors ,  Paul Smith ,  Laurence Patterson

    发明人： Agamemnon Epenetos ,  Klaus Pors ,  Paul Smith ,  Laurence Patterson

    IPC分类号： A61K31/137

    CPC分类号： A61K31/137

    摘要： The present invention generally relates to chemotherapeutic treatment of proliferative disorders, such as cancer. The invention more specifically relates to inhibition of pan-cell cycle progression with alkylating anthraquinones, which may inhibit mitotic commitment, lead to limited expression of G2 arrest and force cells to enter polyploidy via an aberrant mitosis. The methods of the invention are particularly useful in the treatment of chemotherapy-resistant cancers.

    摘要翻译： 本发明一般涉及增生性疾病如癌症的化学治疗。 本发明更具体地涉及用烷基化蒽醌抑制泛细胞周期进程，其可抑制有丝分裂承诺，导致G2阻滞的有限表达，并且通过异常有丝分裂使强制细胞进入多倍体。 本发明的方法在化疗耐药性癌症的治疗中特别有用。

    Anthraquinone and its derivatives
    6.
    发明申请
    Anthraquinone and its derivatives 有权

    公开(公告)号：US20060148777A1

    公开(公告)日：2006-07-06

    申请号：US11367328

    申请日：2006-03-06

    申请人： Paul Smith ,  Laurence Patterson

    发明人： Paul Smith ,  Laurence Patterson

    IPC分类号： A61K31/55 ,  A61K31/445 ,  A61K31/40 ,  A61K31/138

    CPC分类号： G01N33/52 ,  C07C225/36 ,  C09B1/5155

    摘要： There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.

    Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment
    7.
    发明申请
    Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment 有权
    苯并吲哚和苯并喹啉衍生物作为肿瘤治疗的前药

    公开(公告)号：US20070161669A1

    公开(公告)日：2007-07-12

    申请号：US11710899

    申请日：2007-02-27

    申请人： Mark Searcey ,  Laurence Patterson

    发明人： Mark Searcey ,  Laurence Patterson

    IPC分类号： A61K31/473 ,  A61K31/4184 ,  A61K31/4178 ,  A61K31/403 ,  C07D487/02 ,  C07D403/02

    CPC分类号： A61K31/47 ,  A61K31/403 ,  C07D209/60

    摘要： Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which C is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumours. The prodrug is expected to be activated preferentially in tumour cells, which it will act as a DNA alkylating agent preventing cell division.

    摘要翻译： 其中X为H，Y为离去基团的通式（I）或（IA）的化合物优选为芳族DNA结合亚基，为杜卡霉素的前药类似物。 化合物预期在C连接的碳原子上被细胞色素P450特别是CYP1B1羟化，在肿瘤中以高水平表达。 预期前体药物在肿瘤细胞中优先被活化，其将用作防止细胞分裂的DNA烷基化剂。

    Formulations of anthraquinone derivatives
    8.
    发明申请
    Formulations of anthraquinone derivatives 失效
    蒽醌衍生物的配方

    公开(公告)号：US20060205820A1

    公开(公告)日：2006-09-14

    申请号：US11433545

    申请日：2006-05-15

    申请人： William Denny ,  Laurence Patterson ,  Gavin Halbert ,  Steven Ford

    发明人： William Denny ,  Laurence Patterson ,  Gavin Halbert ,  Steven Ford

    IPC分类号： C07C239/16 ,  A61K31/135

    CPC分类号： C07C225/36 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  C07C291/04 ,  C07C2603/24

    摘要： A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R′R″ of at least 2 carbon atoms and R′ and R″ are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups, or R′ and R″ together are a C2-6 alkylene group, is formulated so that upon dissolution in aqueous solution the pH of the solution is in the range of 5 to 9. The compound may be in the form of salt with a physiologically acceptable acid having a pKa in the range of −3.0 (minus 3.0) to 9.0.

    摘要翻译： 式（I）化合物：其中A是具有NH和至少2个碳原子的N（O）R'R“之间的链长的C亚烷基，R'和R”分别选自 C 1-4烷基和C 2-4 2-4羟基烷基和C 2-4 2-4羟基烷基，或者R'和R“一起是 配制C 2-6亚烷基，使得当溶解在水溶液中时，溶液的pH在5至9的范围内。该化合物可以是与生理学上的盐的形式 具有-3.0（减3.0）至9.0范围内的pK 的可接受的酸。