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公开(公告)号：US20110054466A1
公开(公告)日：2011-03-03
申请号：US12771031
申请日：2010-04-30
申请人： Paul T. Rothstein , Cathleen A. Bergin , Cynthia T. Clague , Michael M. Green , Alexander J. Hill , James R. Keogh , Timothy G. Laske
发明人： Paul T. Rothstein , Cathleen A. Bergin , Cynthia T. Clague , Michael M. Green , Alexander J. Hill , James R. Keogh , Timothy G. Laske
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/1492 , A61B2018/00011 , A61B2018/143 , A61B2218/002 , A61B2218/007 , A61F2/82
摘要： An ablation catheter including an inner tube having a length, a distal end and a longitudinal axis, a plurality of needles extending from the distal end of the inner tube and biased away from the longitudinal axis, an outer sheath slideably moveable relative to the inner tube to surround at least a portion of the length of the inner tube and its extending needles, and a radio frequency energy source electrically connected to the plurality of needles.
摘要翻译： 一种消融导管，其包括具有长度，远端和纵向轴线的内管，从所述内管的远端延伸并偏离所述纵向轴线的多个针，相对于所述内管可滑动地移动的外护套 以围绕内管及其延伸针的长度的至少一部分，以及电连接到多个针的射频能量源。
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公开(公告)号：US08801706B2
公开(公告)日：2014-08-12
申请号：US12771031
申请日：2010-04-30
申请人： Paul T. Rothstein , Cathleen A. Bergin , Cynthia T. Clague , Michael M. Green , Alexander J. Hill , James R. Keogh , Timothy G. Laske
发明人： Paul T. Rothstein , Cathleen A. Bergin , Cynthia T. Clague , Michael M. Green , Alexander J. Hill , James R. Keogh , Timothy G. Laske
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/1492 , A61B2018/00011 , A61B2018/143 , A61B2218/002 , A61B2218/007 , A61F2/82
摘要： An ablation catheter including an inner tube having a length, a distal end and a longitudinal axis, a plurality of needles extending from the distal end of the inner tube and biased away from the longitudinal axis, an outer sheath slideably moveable relative to the inner tube to surround at least a portion of the length of the inner tube and its extending needles, and a radio frequency energy source electrically connected to the plurality of needles.
摘要翻译： 一种消融导管，其包括具有长度，远端和纵向轴线的内管，从所述内管的远端延伸并偏离所述纵向轴线的多个针，相对于所述内管可滑动地移动的外护套 以围绕内管及其延伸针的长度的至少一部分，以及电连接到多个针的射频能量源。
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公开(公告)号：US20090222026A1
公开(公告)日：2009-09-03
申请号：US12039629
申请日：2008-02-28
申请人： Paul T. Rothstein , Cynthia T. Clague , Michael M. Green , Damian A. Jelich , Eric A. Meyer , Mark T. Stewart , Chris M. Coppin , Rany Huynh , Mark W. Torrianni , Asha S. Nayak , John R. Liddicoat , Timothy G. Laske
发明人： Paul T. Rothstein , Cynthia T. Clague , Michael M. Green , Damian A. Jelich , Eric A. Meyer , Mark T. Stewart , Chris M. Coppin , Rany Huynh , Mark W. Torrianni , Asha S. Nayak , John R. Liddicoat , Timothy G. Laske
IPC分类号： A61B17/122 , A61B17/128
CPC分类号： A61B17/0057 , A61B17/068 , A61B2017/00243 , A61B2017/00575 , A61B2017/00623 , A61B2017/00867 , A61B2017/0649 , A61B2017/081
摘要： A surgical fastener clip for proximating tissue, the clip providing an undeflected state in which the clip comprises a center portion, a first leg, and a second leg. The center portion has a perimeter defining a circle-like shape. The legs project outwardly relative to the perimeter from a point of departure to a tip. Extension of each of the legs relative to the perimeter defines an identical wind direction that is either clockwise or counterclockwise. The clip optionally includes a linear cross-member extending across the perimeter. The surgical clip can be formed by a wire that is partially wound onto itself in a spiral-like fashion, with the center portion and the legs being co-planar in the undeflected state. During use, the clip is rotated, drawing tissue into the center portion. Systems incorporating the clip are also provided.
摘要翻译： 一种用于接近组织的手术紧固夹，所述夹提供未偏转状态，其中所述夹包括中心部分，第一腿部和第二腿部。 中心部分具有限定圆形形状的周长。 腿从出发点到尖端相对于周边向外突出。 每个腿相对于周边的延伸限定了顺时针或逆时针方向相同的风向。 夹子可选地包括跨越周边延伸的线性横向构件。 手术夹可以由线形成，该线以螺旋状的方式部分地缠绕在自身上，其中心部分和腿在非偏转状态下是共面的。 在使用过程中，夹子旋转，将纸巾拉入中心部分。 还提供了结合夹子的系统。
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公开(公告)号：US08998933B2
公开(公告)日：2015-04-07
申请号：US12039629
申请日：2008-02-28
申请人： Paul T. Rothstein , Cynthia T. Clague , Michael M. Green , Damian A. Jelich , Eric A. Meyer , Mark T. Stewart , Chris M. Coppin , Rany Huynh , Mark W. Torrianni , Asha S. Nayak , John R. Liddicoat , Timothy G. Laske
发明人： Paul T. Rothstein , Cynthia T. Clague , Michael M. Green , Damian A. Jelich , Eric A. Meyer , Mark T. Stewart , Chris M. Coppin , Rany Huynh , Mark W. Torrianni , Asha S. Nayak , John R. Liddicoat , Timothy G. Laske
IPC分类号： A61B17/10 , A61B17/00 , A61B17/064 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/068 , A61B2017/00243 , A61B2017/00575 , A61B2017/00623 , A61B2017/00867 , A61B2017/0649 , A61B2017/081
摘要： A surgical fastener clip for proximating tissue, the clip providing an undeflected state in which the clip comprises a center portion, a first leg, and a second leg. The center portion has a perimeter defining a circle-like shape. The legs project outwardly relative to the perimeter from a point of departure to a tip. Extension of each of the legs relative to the perimeter defines an identical wind direction that is either clockwise or counterclockwise. The clip optionally includes a linear cross-member extending across the perimeter. The surgical clip can be formed by a wire that is partially wound onto itself in a spiral-like fashion, with the center portion and the legs being co-planar in the undeflected state. During use, the clip is rotated, drawing tissue into the center portion. Systems incorporating the clip are also provided.
摘要翻译： 一种用于接近组织的手术紧固夹，所述夹提供未偏转状态，其中所述夹包括中心部分，第一腿部和第二腿部。 中心部分具有限定圆形形状的周长。 腿从出发点到尖端相对于周边向外突出。 每个腿相对于周边的延伸限定了顺时针或逆时针方向相同的风向。 夹子可选地包括跨越周边延伸的线性横向构件。 手术夹可以由线形成，该线以螺旋状的方式部分地缠绕在自身上，其中心部分和腿在非偏转状态下是共面的。 在使用过程中，夹子旋转，将纸巾拉入中心部分。 还提供了结合夹子的系统。
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公开(公告)号：US08241274B2
公开(公告)日：2012-08-14
申请号：US12570888
申请日：2009-09-30
申请人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
发明人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
IPC分类号： A61B18/04
CPC分类号： A61F2/2496 , A61B5/0044 , A61B5/1076 , A61B5/6853 , A61B8/445 , A61B18/1442 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2017/00243 , A61B2018/00291 , A61B2018/00351 , A61B2018/00577 , A61B2034/2051 , A61B2034/2063 , A61B2090/378 , A61B2090/397 , A61F2/2433 , A61F2210/009 , A61F2250/0096 , A61N7/02
摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to place a valve or repair valve and removing the delivery member from the patient. In one aspect of the invention, a delivery system is provided for percutaneous delivery of a heart valve to a predetermined position in the heart of a patient, where the delivery system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a delivery system is provided for percutaneous repair of a heart valve in the heart of a patient, where the repair system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a method and device are provided that involve imaging a native root using an interoperative technique, then introducing a device that is easily visualized in a chosen imaging modality.
摘要翻译： 公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件 的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望的位置以放置瓣膜或修复瓣膜并从患者移除输送构件。 在本发明的一个方面，提供一种用于将心脏瓣膜经皮递送到患者心脏中的预定位置的递送系统，其中递送系统本身包括允许其准确地定位在心脏中的特征。 在本发明的另一方面，提供一种用于经皮修复患者心脏中的心脏瓣膜的递送系统，其中所述修复系统本身包括允许其准确地定位在心脏中的特征。 在本发明的另一方面，提供了一种方法和装置，其涉及使用手术技术对本地根进行成像，然后引入在选择的成像模式中容易可视化的装置。
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公开(公告)号：US20130072786A1
公开(公告)日：2013-03-21
申请号：US13585622
申请日：2012-08-14
申请人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
发明人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
IPC分类号： A61B6/12
CPC分类号： A61F2/2496 , A61B5/0044 , A61B5/1076 , A61B5/6853 , A61B8/445 , A61B18/1442 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2017/00243 , A61B2018/00291 , A61B2018/00351 , A61B2018/00577 , A61B2034/2051 , A61B2034/2063 , A61B2090/378 , A61B2090/397 , A61F2/2433 , A61F2210/009 , A61F2250/0096 , A61N7/02
摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to replace a valve or repair valve and removing the delivery member from the patient.
摘要翻译： 公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件 的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望位置以更换瓣膜或修复瓣膜并从患者移除输送构件。
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公开(公告)号：US20100198346A1
公开(公告)日：2010-08-05
申请号：US12570888
申请日：2009-09-30
申请人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
发明人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
IPC分类号： A61F2/24
CPC分类号： A61F2/2496 , A61B5/0044 , A61B5/1076 , A61B5/6853 , A61B8/445 , A61B18/1442 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2017/00243 , A61B2018/00291 , A61B2018/00351 , A61B2018/00577 , A61B2034/2051 , A61B2034/2063 , A61B2090/378 , A61B2090/397 , A61F2/2433 , A61F2210/009 , A61F2250/0096 , A61N7/02
摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to place a valve or repair valve and removing the delivery member from the patient. In one aspect of the invention, a delivery system is provided for percutaneous delivery of a heart valve to a predetermined position in the heart of a patient, where the delivery system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a delivery system is provided for percutaneous repair of a heart valve in the heart of a patient, where the repair system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a method and device are provided that involve imaging a native root using an interoperative technique, then introducing a device that is easily visualized in a chosen imaging modality.
摘要翻译： 公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件 的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望的位置以放置瓣膜或修复瓣膜并从患者移除输送构件。 在本发明的一个方面，提供一种用于将心脏瓣膜经皮递送到患者心脏中的预定位置的递送系统，其中递送系统本身包括允许其准确地定位在心脏中的特征。 在本发明的另一方面，提供一种用于经皮修复患者心脏中的心脏瓣膜的递送系统，其中所述修复系统本身包括允许其准确地定位在心脏中的特征。 在本发明的另一方面，提供了一种方法和装置，其涉及使用手术技术对本地根进行成像，然后引入在选择的成像模式中容易可视化的装置。
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8.发明授权System and method for closure of an internal opening in tissue, such as a trans-apical access opening 有权用于封闭组织中的内部开口的系统和方法，例如跨顶部进入开口公开(公告)号：US08734484B2
公开(公告)日：2014-05-27
申请号：US12427395
申请日：2009-04-21
申请人： Sarah Ahlberg , Sara Simma , Paul T. Rothstein , Martin Clements , Damian Jelich , Timothy G. Laske , Cynthia Clague , Michael Green , Paul Iaizzo
发明人： Sarah Ahlberg , Sara Simma , Paul T. Rothstein , Martin Clements , Damian Jelich , Timothy G. Laske , Cynthia Clague , Michael Green , Paul Iaizzo
IPC分类号： A61B17/03 , A61B17/122 , A61B17/128 , A61F2/24
CPC分类号： A61B17/0401 , A61B2017/00243 , A61B2017/00663 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/1142
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.
摘要翻译： 一种用于在包括身体组织在内的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子嵌入目标部位。 每个夹子具有相对的夹子端部和中间部分。 柔性系链联接到嵌入的夹子以围绕开口周边形成环。 将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。 环路端部被固定以将目标部位保持在关闭状态。 在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。
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9.发明申请SYSTEM AND METHOD FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 有权用于关闭组织内部开放的系统和方法，例如转接开关公开(公告)号：US20100268253A1
公开(公告)日：2010-10-21
申请号：US12427395
申请日：2009-04-21
申请人： Sarah Ahlberg , Sara Simma , Paul T. Rothstein , Martin Clements , Damian Jelich , Timothy G. Laske , Cynthia Clague , Michael Green , Paul Iaizzo
发明人： Sarah Ahlberg , Sara Simma , Paul T. Rothstein , Martin Clements , Damian Jelich , Timothy G. Laske , Cynthia Clague , Michael Green , Paul Iaizzo
CPC分类号： A61B17/0401 , A61B2017/00243 , A61B2017/00663 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/1142
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.
摘要翻译： 一种用于在包括身体组织在内的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子嵌入目标部位。 每个夹子具有相对的夹子端部和中间部分。 柔性系链联接到嵌入的夹子以围绕开口周边形成环。 将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。 环路端部被固定以将目标部位保持在关闭状态。 在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。
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10.发明授权Stented heart valve devices and methods for atrioventricular valve replacement 有权心脏瓣膜瓣膜置换装置及房室瓣置换方法公开(公告)号：US09510943B2
公开(公告)日：2016-12-06
申请号：US12009323
申请日：2008-01-17
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/82 , A61F2/852 , A61F2/958 , A61F2002/065 , A61F2002/8486 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/005 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0037 , A61F2250/0039 , A61F2250/0064 , A61F2250/0069
摘要： A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.
摘要翻译： 一种用于植入体腔（例如二尖瓣）的可压缩和可扩展的支架组件，所述支架组件包括至少一个成形和尺寸使其允许相邻心脏结构的正常操作的支架筒。 一个或多个支架套筒可以包括在支架组件中，其中一个或多个支架套筒可以包括具有锥形边缘的圆柱体。
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