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公开(公告)号：US5619984A
公开(公告)日：1997-04-15
申请号：US437291
申请日：1995-05-08
IPC分类号： A61K9/14 , A61K45/08 , A61K47/30 , A61M15/00 , A61M15/02 , A61M16/00 , A61P11/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0045 , A61M15/0006 , A61M15/0016 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0066 , A61M15/0078 , A61M15/0085 , A61M15/0091 , A61M15/02 , A61M2016/0024 , A61M2202/064 , A61M2205/8206
摘要： A dry powder inhalation device comprising a housing defining a chamber in communication with a patient port in the form of a mouthpiece or nasal adaptor, and an elongate carrier bearing a powdered medicament, the device being constructed and arranged such that areas of predetermined size of the elongate carrier may sequentially be exposed within the chamber, the device comprising one or more air inlets such that when a patient inhales through the patient port an air flow is established from the air inlet(s) to the patient port through the chamber such that particles of the powdered medicament of respirable size from said exposed area of the elongate carrier are entrained within the air flow.
摘要翻译： 一种干粉吸入装置，其特征在于，包括壳体，所述壳体限定与所述口部或鼻部适配器形式的患者端口连通的室，以及承载有粉末状药物的细长载体，所述装置被构造和布置成使得预定尺寸的 细长的载体可以顺序地在腔室内暴露，该装置包括一个或多个空气入口，使得当患者通过患者端口吸入时，通过腔室从空气入口到患者端口建立空气流，使得颗粒 的来自所述细长载体的所述暴露区域的可吸入尺寸的粉末状药物被夹带在空气流中。
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公开(公告)号：US5482032A
公开(公告)日：1996-01-09
申请号：US273898
申请日：1994-07-12
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0026 , A61M15/0051 , A61M15/0055 , A61M2202/064
摘要： The present invention relates to a device for dislodging powder carried on the surface of a flexible sheet material. The device incorporates a resettable impactor including a head for striking the sheet material, wherein the head comprises an elongate striking surface which is curved in both planes orthoganol to the plan of the sheet material.
摘要翻译： 本发明涉及一种用于移动在柔性片材表面上承载的粉末的装置。 该装置包括可复位冲击器，其包括用于冲击片材的头部，其中头部包括细长的打击表面，该突出表面在与平板材料的平面的正交面的两个平面中弯曲。
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公开(公告)号：US5740793A
公开(公告)日：1998-04-21
申请号：US471612
申请日：1995-06-06
IPC分类号： A61K9/14 , A61K45/08 , A61K47/30 , A61M15/00 , A61M15/02 , A61M16/00 , A61P11/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0045 , A61M15/0006 , A61M15/0016 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0066 , A61M15/0078 , A61M15/0085 , A61M15/0091 , A61M15/02 , A61M2016/0024 , A61M2202/064 , A61M2205/8206
摘要： A dry powder inhalation device comprising a housing defining a chamber in communication with a patient port in the form of a mouthpiece or nasal adaptor, and an elongate carrier bearing a powdered medicament, the device being constructed and arranged such that areas of predetermined size of the elongate carrier may sequentially be exposed within the chamber, the device comprising one or more air inlets such that when a patient inhales through the patient port an air flow is established from the air inlet(s) to the patient port through the chamber such that particles of the powdered medicament of respirable size from said exposed area of the elongate carrier are entrained within the air flow.
摘要翻译： 一种干粉吸入装置，其特征在于，包括壳体，所述壳体限定与所述口部或鼻部适配器形式的患者端口连通的室，以及承载有粉末状药物的细长载体，所述装置被构造和布置成使得预定尺寸的 细长的载体可以顺序地在腔室内暴露，该装置包括一个或多个空气入口，使得当患者通过患者端口吸入时，通过腔室从空气入口到患者端口建立空气流，使得颗粒 的来自所述细长载体的所述暴露区域的可吸入尺寸的粉末状药物被夹带在空气流中。
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公开(公告)号：US6102179A
公开(公告)日：2000-08-15
申请号：US850439
申请日：1997-05-05
CPC分类号： F16D41/18
摘要： A device for the transmission of one-way torque comprising an outer annular member having a plurality of radially inwardly projecting teeth each comprising a driving surface and a cam surface, and a shaft concentrically mounted with respect to the outer annular member and comprising a plurality of drive elements each having a driving surface and a cam surface. Rotation of the shaft or outer annular member in its driving direction causes engagement of a driving surface of at least one drive element with a driving surface of at least one tooth thereby resulting in joint rotation of the shaft and outer annular member. Rotation of the shaft or outer annular member in its non-driving direction causes engagement of the cam surface of at least one drive element with the cam surface of at least one tooth resulting in additional relative movement, substantially radially, between the drive element and tooth, thereby preventing rotational movement being transmitted between the shaft and the outer annular member.
摘要翻译： 一种用于单向扭矩传递的装置，包括具有多个径向向内突出的齿的外环形构件，每个径向向内突出的齿各自包括驱动表面和凸轮表面，以及相对于外环形构件同心安装的轴， 驱动元件各自具有驱动表面和凸轮表面。 轴或外环形构件沿其驱动方向的旋转使得至少一个驱动元件的驱动表面与至少一个齿的驱动表面接合，从而导致轴和外环形构件的联合旋转。 轴或外环形构件在其非驱动方向上的旋转导致至少一个驱动元件的凸轮表面与至少一个齿的凸轮表面的接合，从而在驱动元件和齿之间基本上径向地进一步相对移动 从而防止旋转运动在轴和外环形构件之间传递。
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公开(公告)号：US06460537B1
公开(公告)日：2002-10-08
申请号：US09437047
申请日：1999-11-09
IPC分类号： A61M1100
CPC分类号： A61M15/0091 , A61M15/0081 , A61M15/009 , A61M15/0093
摘要： A dispenser for dispensing a product from a pressurized product container comprising a housing defining a user port and adapted to have a pressurized product container mounted therein, the pressurized product container having a dispensing valve movable relative to the container between an open and a closed position; the housing further comprising a rolling member comprising a vane, and two associated rolling surfaces, the rolling member being capable of rotation in contact with the rolling surfaces such that they translate in opposite directions relative to the rolling member in response to inhalation through the user port, the rolling member being rotatable between a locking position in which the rolling member directly or indirectly engages the pressurized product container or valve to maintain the valve in the closed position, and a release position in which the valve and the pressurized product container move relative to each other so that the valve moves to the open position to dispense product from the container and towards the user port.
摘要翻译： 一种用于从加压产品容器分配产品的分配器，包括限定用户端口并适于安装在其中的加压产品容器的壳体，所述加压产品容器具有可在打开和关闭位置之间相对于容器移动的分配阀; 所述壳体还包括滚动构件，所述滚动构件包括叶片和两个相关联的滚动表面，所述滚动构件能够旋转地与所述滚动表面接触，使得所述滚动构件响应于通过所述用户端口的吸入而相对于所述滚动构件在相反方向上平移 所述滚动构件可在锁定位置之间旋转，在所述锁定位置中，所述滚动构件直接或间接地接合所述加压产品容器或阀，以将所述阀保持在关闭位置;以及释放位置，其中所述阀和所述加压产品容器相对于 彼此使得阀移动到打开位置以从容器和用户端口分配产品。
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公开(公告)号：US5408994A
公开(公告)日：1995-04-25
申请号：US50440
申请日：1993-05-11
CPC分类号： A61M15/0091 , A61M15/009
摘要： An inhalation device for administration of aerosolized medicament to the respiratory system of a patient comprising a housing defining a patient port and an air inlet, the housing containing means for dispensing a dose of aerosolized medicament, an inhalation-activatable triggering mechanism for initiating the dispensing means, and reset means. The triggering mechanism comprises a vane mounted for pivotable movement between closed and open positions, the vane being positioned within the patient port such that inhalation through the patient port generates an airflow from the air inlet to the patient port causing pivotable movement of the vane. The device further includes an activator component moveable between a restrained position and a dispensing position which movement causes dispensing of medicament from the dispensing means, the activator component being biased towards its dispensing position.
摘要翻译： PCT No.PCT / GB91 / 01983 Sec。 371日期：1993年5月11日 102（e）日期1993年5月11日PCT 1991年11月12日PCT PCT。 公开号WO92 / 08509 日期：1992年5月29日。一种用于向患者的呼吸系统施用雾化药物的吸入装置，包括限定患者口和空气入口的壳体，所述壳体容纳装置用于分配雾化药剂的剂量，可吸入激活的触发 用于启动分配装置的机构和复位装置。 触发机构包括安装成用于在闭合位置和打开位置之间可枢转运动的叶片，叶片定位在患者端口内，使得通过患者端口的吸入产生从空气入口到患者端口的气流，引起叶片的可枢转运动。 该装置还包括可在限制位置和分配位置之间移动的活化剂组件，该运动导致药物从分配装置分配，活化剂组分被偏向其分配位置。
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公开(公告)号：US5192548A
公开(公告)日：1993-03-09
申请号：US516327
申请日：1990-04-30
CPC分类号： A61K9/0075 , A61J3/00 , A61M15/0045 , A61M15/0051 , A61M15/02 , B29C65/18 , B29C66/81457 , B29C66/83413 , B29K2821/00 , B29L2031/7164 , B29L2031/753
摘要： A sheet material comprising discrete depressions which are at least partially filled with micronized medicament and which are useful as or in a drug delivery device. This sheet material is useful in devices which provide for aerosolization of the medicament, for delivery to a patient by inhalation.
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公开(公告)号：US5347998A
公开(公告)日：1994-09-20
申请号：US965406
申请日：1992-12-23
CPC分类号： A61M15/0091
摘要： An inhalation device for use with a pressurized aerosol canister. The device involves an electromechanical mechanism for applying a priming force to the aerosol canister prior to or at the start of inhalation. The device also involves a blocking mechanism. The electromechanical mechanism electromechanically applies to the aerosol canister a priming force sufficient to actuate the aerosol canister, and the blocking mechanism prevents the priming force from actuating the aerosol canister until inhalation is detected.
摘要翻译： PCT No.PCT / GB91 / 01116 Sec。 371日期1992年12月23日 102（e）日期1992年12月23日PCT提交1991年7月8日PCT公布。 出版物WO92 / 00770 日期1992年1月23日。用于加压气溶胶罐的吸入装置。 该装置涉及一种机电机构，用于在吸入之前或开始时向喷雾罐施加起动力。 该装置还涉及阻塞机制。 机电机构在气溶胶罐上机电地施加足以致动气溶胶罐的起动力，并且阻塞机构防止起动力致动气溶胶罐直到检测到吸入。
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公开(公告)号：US09067031B2
公开(公告)日：2015-06-30
申请号：US12444864
申请日：2007-10-19
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译： 一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气溶胶制剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种 多孔的，可流体渗透的，颗粒状的半渗透体，所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游 的计量室。
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公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译： 干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内， 载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置 在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。
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