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9 条记录 (耗时 0.021 秒)

    Error checking in blood analyzer
    5.
    发明授权
    Error checking in blood analyzer 失效
    血液分析仪检查错误

    公开(公告)号：US5590052A

    公开(公告)日：1996-12-31

    申请号：US227554

    申请日：1994-04-14

    申请人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    发明人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    IPC分类号： G01N21/25 ,  G01N35/00 ,  G01N35/02 ,  G01N21/17

    CPC分类号： G01N35/00594 ,  G01N21/253 ,  G01N35/025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

    摘要： The present invention provides various methods for detecting errors in a blood analysis system. The system includes a blood analyzer and a molded plastic rotor with a series of chambers and capillary channels through which blood is processed and distributed to cuvettes which contain lyophilized reagents. The rotor is placed in the analyzer which spins the rotor, and an optical system reads the cuvettes as light is flashed through the cuvettes. The invention provides checks for: confirming the presence of a reagent in the cuvettes before a sample is applied to the cuvettes; determining whether a fluid sample has been properly distributed to the cuvettes of the rotor; determining whether an adequate amount of fluid sample was applied to the analytical rotor; determining whether a fluid sample has been properly distributed to a cuvette of an analytical rotor; determining whether a reaction chemistry in a cuvette has reached an end point; checking the noise level and non-linearity of a reaction rate in a cuvette; determining whether an adequate amount of diluent was delivered to the cuvettes of an analytical rotor; determining dilution systematic failure when measuring different reaction chemistries in the cuvettes of the rotor; determining whether a blood sample in a cuvette is hemolyzed, lipemic, or icteric; determining the degradation of a reagent in a cuvette; determining proper light source and light detector operation; and determining proper motor function and cuvette mark detection.

    摘要翻译： 本发明提供了用于检测血液分析系统中的错误的各种方法。 该系统包括血液分析仪和具有一系列腔室和毛细通道的模制塑料转子，通过血液分析器和毛细管通道将血液加工并分配到含有冻干试剂的比色皿。 将转子放置在旋转转子的分析仪中，当光通过反应杯闪烁时，光学系统读取比色皿。 本发明提供了以下检查：在将样品施加到比色杯之前，确认试剂在试管中的存在; 确定流体样品是否已经被适当地分配到转子的比色杯中; 确定足够量的流体样品是否被施加到分析转子; 确定流体样品是否已经被适当地分配到分析转子的比色杯中; 确定比色皿中的反应化学物质是否达到终点; 检查反应杯中的反应速率的噪声水平和非线性; 确定足够量的稀释剂是否被输送到分析转子的比色杯中; 测量转子的比色杯中的不同反应化学物质时的稀释系统失效; 确定比色皿中的血液样品是否溶血，脂肪或黄疸; 确定试剂在试管中的降解; 确定适当的光源和光检测器的操作; 并确定适当的运动功能和比色皿标记检测。

    Apparatus and method for the separation of immiscible liquids
    7.
    发明授权
    Apparatus and method for the separation of immiscible liquids 失效
    用于分离不混溶液体的装置和方法

    公开(公告)号：US4971912A

    公开(公告)日：1990-11-20

    申请号：US73050

    申请日：1987-07-14

    申请人： Steven N. Buhl ,  Syed I. Ahmad ,  Arden Grassick

    发明人： Steven N. Buhl ,  Syed I. Ahmad ,  Arden Grassick

    IPC分类号： G01N33/48 ,  B01D17/02 ,  B01D17/022 ,  G01N1/28 ,  G01N1/34

    CPC分类号： G01N1/34 ,  B01D17/0202 ,  G01N2001/4061 ,  Y10T436/117497 ,  Y10T436/118339

    摘要： Apparatus and method for the separation of immiscible liquids are provided, and comprise the use of separator means having a surface which is preferentially "wettable" by one of the liquids to the substantial exclusion of another of the liquids. In use, the liquids are flowed from a common liquid source onto said surface with the one liquid being sorbed thereby to the substantial exclusion of the other liquid to thus substantially separate the liquids. The separator means surface may be maintained essentially level to retain the substantially separated liquid thereon, or may be inclined to result in the flow of the same therefrom under the influence of the force of gravity. Alternatively, the separator means may be made of a liquid-permeable material to permit the flow of the substantially separated liquid therethrough and therefrom under the influence of the force of gravity. The apparatus and method are particularly adapted to the substantial separation of aqueous sample liquids from hydrophobic isolation liquids which encapsulate the same; and are readily combinable with a sample liquid reaction device to effectively combine the sample liquid separation and reaction operations. The material of the separator means may be inherently hydrophobic, or may be rendered super-hydrophobic by the surface coating thereof with a super-hydrophobic coating material.

    摘要翻译： 提供了用于分离不混溶液体的装置和方法，并且包括使用具有优选地被其中一种液体“润湿”的表面的分离器装置，从而基本排除另一种液体。 在使用中，液体从公共液体源流到所述表面上，其中一种液体被吸收，从而基本排除其它液体，从而基本上分离液体。 分离器装置的表面可以保持基本上水平以将基本上分离的液体保持在其上，或者可以在重力的影响下倾斜以导致其相同的流动。 或者，分离器装置可以由液体可渗透的材料制成，以允许基本分离的液体在重力的影响下通过其流过。 该装置和方法特别适用于水性样品液体与其封装的疏水隔离液体的实质分离; 并且可以容易地与样品液体反应装置组合，以有效地组合样品液体分离和反应操作。 分离器装置的材料可以是固有的疏水性的，或者可以通过其超疏水涂层材料的表面涂层使其变得超疏水。

    Cryogenic apparatus
    9.
    发明授权
    Cryogenic apparatus 失效
    低温装置

    公开(公告)号：US5275016A

    公开(公告)日：1994-01-04

    申请号：US873327

    申请日：1992-04-24

    申请人： Bikash K. Chatterjee ,  Steven N. Buhl ,  Chi-Sou Yu ,  Thuy N. Tang ,  Gary L. Smith ,  Bhaskar Bhayani ,  Anthony Alvarado ,  Swee Wong

    发明人： Bikash K. Chatterjee ,  Steven N. Buhl ,  Chi-Sou Yu ,  Thuy N. Tang ,  Gary L. Smith ,  Bhaskar Bhayani ,  Anthony Alvarado ,  Swee Wong

    IPC分类号： F25D3/10 ,  A23L3/375 ,  A61J3/00 ,  A61J3/06 ,  B01J19/06 ,  F25C1/00 ,  F26B5/06 ,  G01N1/42 ,  F25D25/02

    CPC分类号： A23L3/375 ,  B01J19/06 ,  F25C1/00 ,  F26B5/06 ,  G01N1/42

    摘要： The present invention provides methods and devices for freezing drops of liquid reagent solution in a cryogenic liquid. In one embodiment, the apparatus of the present invention comprises means for dispensing uniform, precisely measured drops of a liquid reagent and a rotatable carousel positioned below the dispensing means. The upper surface of the carousel has a plurality of trays each containing a cryogenic liquid, typically liquid nitrogen, for receiving the drops of liquid reagent. An alternative embodiment of the present invention comprises a tank comprising a cryogenic liquid for receiving the drops of liquid reagent. The tank has a heat source for slightly heating a portion of the cryogenic liquid such that a convection current in the cryogenic liquid is created. The convection currents in the cryogenic liquid provide mild agitation of the liquid and prevent aggregation of the frozen drops.

    摘要翻译： 本发明提供用于冷冻液体试剂溶液在低温液体中的液滴的方法和装置。 在一个实施例中，本发明的装置包括用于分配均匀的精确测量的液体试剂液滴和位于分配装置下方的可旋转转盘的装置。 转盘的上表面具有多个托盘，每个托盘包含用于接收液体试剂液滴的低温液体，通常为液氮。 本发明的替代实施方案包括一个包含用于接收液体试剂滴的低温液体的罐。 罐具有用于稍微加热部分低温液体的热源，使得产生低温液体中的对流。 低温液体中的对流电流提供液体的温和搅拌并防止冷冻液滴的聚集。