公开(公告)号：US20060230818A1

公开(公告)日：2006-10-19

申请号：US11107996

申请日：2005-04-14

申请人： Phillip Barth ,  Derek Stein ,  Curt Flory ,  Rick Pittaro ,  Daniel Roitman

发明人： Phillip Barth ,  Derek Stein ,  Curt Flory ,  Rick Pittaro ,  Daniel Roitman

IPC分类号： H01L31/072

CPC分类号： G01Q30/02 ,  G01N15/1031

摘要： Planar resonant tunneling sensor devices and methods for using the same are provided. The subject devices include first and second electrodes present on a surface of a planar substrate and separated from each other by a nanodimensioned gap. The devices also include a first member for holding a sample, and a second member for moving the first member and planar resonant tunneling electrode relative to each other. Also provided are methods of fabricating such a device and methods of using such a device for improved detection and characterization of a sample.

摘要翻译： 提供了平面谐振隧道传感器装置及其使用方法。 本装置包括存在于平面基板表面上的第一和第二电极，并通过纳米尺寸的间隙彼此分离。 这些装置还包括用于保持样品的第一构件和用于相对于彼此移动第一构件和平面谐振隧穿电极的第二构件。 还提供了制造这种装置的方法和使用这种装置来改进样品的检测和表征的方法。

公开(公告)号：US20060068401A1

公开(公告)日：2006-03-30

申请号：US10957378

申请日：2004-09-30

申请人： Curt Flory ,  Richard Pittaro ,  Phillip Barth

发明人： Curt Flory ,  Richard Pittaro ,  Phillip Barth

IPC分类号： C12Q1/68 ,  H01L29/82

CPC分类号： G01N33/48721 ,  B82Y10/00 ,  B82Y15/00 ,  G01N15/1031

摘要： The invention provides an apparatus and method for sequencing and identifying a biopolymer. The invention provides a first electrode, a second electrode, a first gate electrode, a second gate electrode, a gate voltage source and a potential means. The gate electrodes may be ramped by a voltage source to search and determine a resonance level between the first electrode, biopolymer and second electrode. The potential means that is in electrical connection with the first electrode and the second electrode is maintained at a fixed voltage. A method of biopolymer sequencing and identification is also disclosed.

公开(公告)号：US20060071209A1

公开(公告)日：2006-04-06

申请号：US10996846

申请日：2004-11-23

申请人： Curt Flory ,  Richard Pittaro ,  Phillip Barth

发明人： Curt Flory ,  Richard Pittaro ,  Phillip Barth

IPC分类号： H01M8/16 ,  G01R31/26

CPC分类号： G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N15/1031 ,  C12Q2565/631

摘要： The invention provides an apparatus and method for sequencing and identifying a biopolymer. The invention provides a first electrode, a second electrode, a first gate electrode, a second gate electrode, a gate voltage source and a potential means. The gate electrodes may be ramped by a voltage source to search and determine a resonance level between the first electrode, biopolymer and second electrode. The potential means that is in electrical connection with the first electrode and the second electrode is maintained at a fixed voltage. A method of biopolymer sequencing and identification is also disclosed.

公开(公告)号：US20070138132A1

公开(公告)日：2007-06-21

申请号：US10462216

申请日：2003-06-12

申请人： Phillip Barth

发明人： Phillip Barth

IPC分类号： B31D3/00 ,  C23C14/00

CPC分类号： G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00

摘要： The present invention provides an apparatus and method for making an apparatus for sensing and/or characterizing a biopolymer translocating a nanopore. The apparatus of the present invention provides a first electrode, a first insulator, a second electrode, a optional insulator, a voltage source for applying a time varying potential difference between the electrodes, and a means of measuring the resulting current between the two electrodes. A method for making the apparatus is also disclosed.

摘要翻译： 本发明提供了一种用于制造用于感测和/或表征易位纳米孔的生物聚合物的装置的装置和方法。 本发明的装置提供了一种第一电极，第一绝缘体，第二电极，任选的绝缘体，用于在电极之间施加时变电位差的电压源，以及测量两个电极之间产生的电流的装置。 还公开了一种制造该装置的方法。

公开(公告)号：US5969736A

公开(公告)日：1999-10-19

申请号：US116427

申请日：1998-07-14

申请人： Leslie A. Field ,  Phillip Barth ,  David J. Waller ,  George D. Zuras, Jr. ,  Paul P. Merchant ,  Storrs Hoen ,  Channing R. Robertson

发明人： Leslie A. Field ,  Phillip Barth ,  David J. Waller ,  George D. Zuras, Jr. ,  Paul P. Merchant ,  Storrs Hoen ,  Channing R. Robertson

IPC分类号： B41J2/055 ,  B41J2/175

CPC分类号： B41J2/17556 ,  B41J2/055 ,  B41J2202/05

摘要： A pressure regulator that sets the pressure of a liquid to a predetermined pressure differential below a reference pressure, such as atmospheric pressure. The pressure regulator comprises a liquid delivery channel and a capillary array. The liquid delivery channel includes a liquid input and a liquid output. The liquid flows through the liquid delivery channel from the liquid input to the liquid output. The capillary array is composed of ones of an elongate capillary. The capillary includes a first end in fluid communication with the liquid delivery channel and a second end in pressure communication with a source of the reference pressure. The liquid flows through the first end into the capillary to form a liquid surface in the capillary. The second end is remote from the first end. The capillary has cross-sectional dimensions in relation to the surface tension of the liquid and the angle of contact between the liquid and the capillary such that the pressure drop across the liquid surface in the capillary is equal to the predetermined pressure differential.

摘要翻译： 一种压力调节器，其将液体的压力设定为低于参考压力（例如大气压）的预定压差。 压力调节器包括液体输送通道和毛细管阵列。 液体输送通道包括液体输入和液体输出。 液体通过液体输送通道从液体输入流到液体输出。 毛细管阵列由细长毛细管组成。 毛细管包括与液体输送通道流体连通的第一端和与参考压力的源压力连通的第二端。 液体通过第一端流入毛细管，以在毛细管中形成液体表面。 第二端远离第一端。 毛细管具有与液体的表面张力和液体和毛细管之间的接触角相关的横截面尺寸，使得毛细管中的液体表面上的压降等于预定的压力差。

公开(公告)号：US20060257096A1

公开(公告)日：2006-11-16

申请号：US11441600

申请日：2006-07-12

申请人： Phillip Barth

发明人： Phillip Barth

IPC分类号： G02B6/00

CPC分类号： G02B6/132 ,  G02B6/12 ,  G02B2006/12038 ,  G02B2006/12061

摘要： Systems and methods for designing and fabricating multi-layer structures having thermal expansion properties are provided. One embodiment of the present invention provides a multi-layer structure. Briefly described, one such multi-layer structure comprises a central layer, a first layer, and a second layer. The first layer is constrained to a first side of the central layer and has a first thickness. The first layer comprises a first material having a first value for a thermal expansion property. The second layer is constrained to a second side of the central layer and has a second thickness. The second layer comprises a second material having a second value for a thermal expansion property. The second thickness and the second value for the thermal expansion property and the first thickness and the first value for the thermal expansion property are such that, upon a change in temperature, the net change in the strain energy in the first layer and the net change in the strain energy in the second layer are substantially equal.

公开(公告)号：US20060254696A1

公开(公告)日：2006-11-16

申请号：US11441599

申请日：2006-07-11

申请人： Phillip Barth

发明人： Phillip Barth

IPC分类号： G02B6/10

CPC分类号： G02B6/132 ,  G02B6/12 ,  G02B2006/12038 ,  G02B2006/12061

摘要： Systems and methods for designing and fabricating multi-layer structures having thermal expansion properties are provided. One embodiment of the present invention provides a multi-layer structure. Briefly described, one such multi-layer structure comprises a central layer, a first layer, and a second layer. The first layer is constrained to a first side of the central layer and has a first thickness. The first layer comprises a first material having a first value for a thermal expansion property. The second layer is constrained to a second side of the central layer and has a second thickness. The second layer comprises a second material having a second value for a thermal expansion property. The second thickness and the second value for the thermal expansion property and the first thickness and the first value for the thermal expansion property are such that, upon a change in temperature, the net change in the strain energy in the first layer and the net change in the strain energy in the second layer are substantially equal.

公开(公告)号：US20050069687A1

公开(公告)日：2005-03-31

申请号：US10670554

申请日：2003-09-25

申请人： Phillip Barth

发明人： Phillip Barth

IPC分类号： B32B7/02 ,  B81B1/00 ,  B81B3/00 ,  B81C1/00 ,  B81C99/00 ,  B82B3/00

CPC分类号： B81B3/0072 ,  B81B2203/0127 ,  B81B2203/0353 ,  B81C2201/0167 ,  Y10T428/24942 ,  Y10T428/24975

摘要： An apparatus and method for making a composite tensile diaphragm having a nanopore. The apparatus provides a tensile layer in contact with a compressive layer. A small region of the tensile layer is removed to expose a small portion of the compressive layer. The compressive region of the tensile layer is small enough to avoid the buckling or wrinkling of the material. The apparatus has a length to thickness ratio from 10 to 60. Also disclosed is a method of making the apparatus.

摘要翻译： 一种用于制造具有纳米孔的复合拉伸隔膜的装置和方法。 该装置提供与压缩层接触的拉伸层。 去除拉伸层的小区域以暴露压缩层的一小部分。 拉伸层的压缩区域足够小以避免材料的翘曲或起皱。 该装置的长度与厚度之比为10至60.还公开了制造该装置的方法。

公开(公告)号：US20050022895A1

公开(公告)日：2005-02-03

申请号：US10632175

申请日：2003-07-30

申请人： Phillip Barth ,  George Yefchak

发明人： Phillip Barth ,  George Yefchak

IPC分类号： B01D19/00 ,  B01L3/00 ,  B01L3/02 ,  G01N35/10 ,  B67C3/00

CPC分类号： B01L3/0268 ,  B01D19/00 ,  B01L3/502723 ,  B01L2200/0642 ,  B01L2200/0684 ,  G01N2035/1018 ,  Y10T137/206

摘要： The present invention is directed to methods and apparatus for removing a gaseous bubble confined in a microvolume of liquid in a chamber. A source of liquid, a barrier region and an exit region are provided in fluid communication with the chamber. The source of liquid has an energy potential as regards movement of the gaseous bubble that is higher than the energy potential of the barrier region, the barrier region has a higher energy potential than the chamber, and the chamber has a higher energy potential than the exit region. The energy potential is reduced within the chamber, the source of liquid, the barrier region, and the exit region by an amount such that the energy within the gaseous bubble is sufficient to displace the gaseous bubble from the chamber through the barrier region and out the exit region and to fill the chamber with the liquid from the source.

摘要翻译： 本发明涉及用于去除限制在室中的微量液体中的气泡的方法和装置。 提供液体源，阻挡区域和出口区域与腔室流体连通。 液体源对气泡的移动具有高于势垒区的能量势的能量势垒，势垒区具有比腔更高的能量势，并且腔具有比出口更高的能量势 地区。 在室内，液体源，阻挡区域和出口区域中的能量电位减小了一定量，使得气泡内的能量足以使气泡从室通过阻挡区域移出， 出口区域并用来自源的液体填充室。

公开(公告)号：US20050014162A1

公开(公告)日：2005-01-20

申请号：US10622367

申请日：2003-07-17

申请人： Phillip Barth ,  Carl Myerholtz

发明人： Phillip Barth ,  Carl Myerholtz

IPC分类号： B01L3/00 ,  C12M1/34 ,  C12Q1/68

CPC分类号： G01N33/48721 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0663 ,  B01L2300/0816 ,  B01L2300/0896 ,  B01L2400/0421 ,  B82Y30/00 ,  C12Q1/6869 ,  C12Q2565/631

摘要： The present invention provides an apparatus and method for threading a biopolymer through a nanopore. The apparatus of the present invention provides a substrate having a channel with a channel wall and a nanopore in the channel wall. The channel and nanopore are designed for receiving a biopolymer. The apparatus includes at least one set of electrodes for moving the biopolymer in a first direction past the nanopore, and at least one set of electrodes for moving the biopolymer through the nanopore in a second direction. The invention also provides a method for threading a biopolymer through a nanopore. The method includes moving the biopolymer past the nanopore in a first direction, and threading the biopolymer through the nanopore in a second direction.

摘要翻译： 本发明提供了一种通过纳米孔螺旋生物聚合物的装置和方法。 本发明的装置提供了一种在通道壁中具有通道壁和纳米孔的通道的基底。 通道和纳米孔被设计用于接收生物聚合物。 该装置包括至少一组用于沿第一方向移动生物聚合物的一组电极通过纳米孔，以及至少一组用于沿第二方向移动生物聚合物通过纳米孔的电极。 本发明还提供了一种通过纳米孔螺旋生物聚合物的方法。 该方法包括沿着第一方向移动生物聚合物超过纳米孔，并沿着第二方向将生物聚合物穿过纳米孔。