Identification of bacteria and spores
    6.
    发明申请
    Identification of bacteria and spores 审中-公开
    鉴定细菌和孢子

    公开(公告)号:US20070003996A1

    公开(公告)日:2007-01-04

    申请号:US11350269

    申请日:2006-02-09

    CPC classification number: C12Q1/04 G01N27/624 G01N33/497

    Abstract: Bacteria can be identified by analyzing a data stream that is obtained by processing a sample containing the bacteria, where the data stream has been abstracted to produce a sample vector that characterizes the data stream in a predetermined vector space containing at least one diagnostic cluster, the diagnostic cluster being associated with bacteria of known type, and by determining whether the sample vector rests with the diagnostic cluster, and if the sample rests within the diagnostic cluster, an indication that the bacteria are of the known type can be provided. Similarly, spores can be identified by analyzing a data stream that is obtained by processing a sample containing the spores, where the data stream has been abstracted to produce a sample vector that characterizes the data stream in a predetermined vector space containing at least one diagnostic cluster, the diagnostic cluster being associated with spores of known type, and by determining whether the sample vector rests with the diagnostic cluster, and if the sample rests within the diagnostic cluster, an indication that the spores are of the known type can be provided.

    Abstract translation: 可以通过分析通过处理含有细菌的样品获得的数据流来识别细菌,其中数据流已经被抽象以产生在包含至少一个诊断簇的预定向量空间中表征数据流的样本载体, 诊断簇与已知类型的细菌相关联,并且通过确定样品载体是否与诊断簇相关,并且如果样品搁置在诊断簇内,则可以提供细菌是已知类型的指示。 类似地,可以通过分析通过处理含有孢子的样品获得的数据流来识别孢子,其中数据流已被抽象,以产生在包含至少一个诊断簇的预定向量空间中表征数据流的样本向量 ,诊断簇与已知类型的孢子相关联,并且通过确定样品载体是否与诊断簇相关,并且如果样品搁置在诊断簇内,则可以提供孢子是已知类型的指示。

    Systems and methods for testing a biological sample
    8.
    发明授权
    Systems and methods for testing a biological sample 有权
    用于测试生物样品的系统和方法

    公开(公告)号:US08315805B2

    公开(公告)日:2012-11-20

    申请号:US10128680

    申请日:2002-04-22

    CPC classification number: G06F19/18 G06F19/28

    Abstract: Systems and methods for testing samples, particularly biological samples are provided. The system includes an instrument for detecting molecules in samples, and a processor that communicates with the instrument to provide results-based control of the instrument to effect assay-based judging. For example, a system, including software, is provided that directs and performs assays such as diagnostic assays that employ a mass spectrometer. The output of the system, rather than a mass spectrum or other raw data form, is the diagnostic outcome, such as a genotype.

    Abstract translation: 提供了用于测试样品,特别是生物样品的系统和方法。 该系统包括用于检测样品中的分子的仪器,以及与仪器通信以提供仪器的基于结果的控制以进行基于测定的判断的处理器。 例如,提供包括软件的系统,其指导和执行诸如使用质谱仪的诊断测定法的测定。 系统的输出,而不是质谱或其他原始数据形式是诊断结果,如基因型。

    Method and device for identifying a biological sample
    9.
    发明授权
    Method and device for identifying a biological sample 有权
    用于识别生物样品的方法和装置

    公开(公告)号:US07917301B1

    公开(公告)日:2011-03-29

    申请号:US09663968

    申请日:2000-09-19

    Applicant: Ping Yip

    Inventor: Ping Yip

    CPC classification number: G06F17/00 G06F19/00

    Abstract: The method and system for identifying a biological sample generates a data set indicative of the composition of the biological sample. In a particular example, the data set is DNA spectrometry data received from a mass spectrometer. The data set is denoised, and a baseline is deleted. Since possible compositions of the biological sample may be known, expected peak areas may be determined. Using the expected peak areas, a residual baseline is generated to further correct the data set. Probable peaks are then identifiable in the corrected data set, which are used to identify the composition of the biological sample. In a disclosed example, statistical methods are employed to determine the probability that a probable peak is an actual peak, not an actual peak, or that the data are too inconclusive to call.

    Abstract translation: 用于识别生物样品的方法和系统产生指示生物样品的组成的数据集。 在特定的例子中,数据集是从质谱仪接收的DNA光谱数据。 数据集被去噪,基线被删除。 由于生物样品的可能组成可能是已知的,所以可以确定预期的峰面积。 使用预期的峰值区域,生成剩余基线以进一步校正数据集。 然后可以在校正数据集中识别可能的峰,其用于鉴定生物样品的组成。 在公开的示例中,采用统计方法来确定可能峰值是实际峰值而不是实际峰值的可能性,或者数据对于呼叫来说太不确定。

    Automated process line
    10.
    发明授权
    Automated process line 有权
    自动化生产线

    公开(公告)号:US06730517B1

    公开(公告)日:2004-05-04

    申请号:US09680581

    申请日:2000-10-05

    Abstract: Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

    Abstract translation: 提供了具有用于分析生物聚合物样品(如核酸,蛋白质,肽和碳水化合物)的集成仪器的全自动模块化分析系统。 检测和分析的分析方法,如质谱,放射性标记,质量标签,化学标签和荧光化学发光,与机器人技术和自动化学反应系统集成,提供高通量,精确的自动生产线(APL)。

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