摘要:
Embodiments of the present invention provide a low voltage continuous time common mode feedback (CMFB) module, for low voltage operational amplifiers, providing good linearity, wide bandwidth and low systematic offset. The common mode feedback module includes a controlling module and an initializing module. The controlling module and the initializing module are parallel common mode feedback loops. The controlling module is a main CMFB loop and the initializing module is an auxiliary CMFB loop and both the loops work simultaneously. The controlling module and the initializing module receive a first differential input voltage and a second differential input voltage supplied by differential outputs of a main differential amplifier. Both the CMFB loops are low gain amplifiers in order to provide operation as linear as possible over the entire differential output operating range of the main differential amplifier.
摘要:
Embodiments of the present invention disclose operational amplifiers which demonstrate good settling behavior with minimum over-shoot or ringing for improving settling behavior. The amplifiers include one or more amplification stages connected to form a symmetric structure. The amplification stage includes a boosting amplifier, a MOS transistor and a compensation capacitor. The MOS transistor can be an NMOS transistor and a PMOS transistor. Using this scheme pole-zero doublets are rearranged in a manner to improve the transient settling response.
摘要:
A continuous time common mode feedback module is capable of operating in a wide range of input voltages. The common mode feedback module includes a common mode detector and an amplifier for computing and amplifying the difference of a reference voltage and a common mode voltage of a first input signal and a second input signal. The common-mode feedback module includes a common mode resolver and a control voltage generating module coupled to each other to provide a common mode feedback voltage. The common mode feedback module provides a good linearity and a wide bandwidth, without compensation requirements. The common mode feedback module also provides small process corner dependence of bias current and a common mode offset.
摘要:
The present disclosure relates to reduction in the effect of kickback in comparators by means of charge injection implemented by means of voltage controlled switches with attributes similar to those of an input differential pair. The voltage controlled switches produce charge to neutralize the charge loss during latching of inputs in the comparator.
摘要:
The present disclosure relates to reduction in the effect of kickback in comparators by means of charge injection implemented by means of voltage controlled switches with attributes similar to those of an input differential pair. The voltage controlled switches produce charge to neutralize the charge loss during latching of inputs in the comparator.
摘要:
Methods are disclosed for designing an antibody reagent for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for the analyte. The method comprises controlling, in the preparation of the conjugate, reaction parameters comprising the hydrophobicity or hydrophilicity of the spacer group, the length of the spacer group, the number of molecules of the small molecule attached to the antibody and the point of attachment of the small molecule to the antibody to obtain an optimum assay sensitivity and/or dynamic range. In some embodiments the method comprises preparing two or more conjugates by selecting a set of parameters for each conjugate wherein the set of parameters is different for each conjugate, conducting an assay for the analyte employing each conjugate and selecting for use in the assay the conjugate that provides the optimum assay sensitivity and/or dynamic range.
摘要:
The present application relates to a method of making liposomes having membrane proteins incorporated therein, the method comprising: providing the membrane protein in solution; providing a solution of preformed liposomes; and incubating the mixture. Prior to the step of providing a solution of preformed liposomes, the liposomes are formed by combining a mixture of phospholipids with a solution of at least one type of unsaturated fatty acid. The methods of the present invention further relate to the method of making a reagent comprising tissue factor reconstituted into preformed liposomes. The method of the present invention for making a tissue factor reagent comprises: providing tissue factor in solution; providing a solution of preformed liposomes comprising a mixture of phospholipids and at least one type of unsaturated fatty acid; and incubating the mixture.
摘要:
Methods and compositions are provided for specific binding assays in which specific binding reagents are immobilized on a solid phase. Immobilization is facilitated by covalently coupling specific binding assay reagents such as polypeptide receptors or analytes with water soluble polymers. Such water soluble polymers, for example star polymers such as dendrimers, provide production advantages of lot-to-lot uniformity and homogeneity, and can enhance sensitivity due to low non-specific binding to the solid phase.
摘要:
A method and system for performing data manipulation on a storage device is disclosed. A data manipulation command is created on a computing device, wherein the computing device is separate from the storage device. The computing device is a client or a server that requests services of a storage system to store data on a storage medium. The computing device and the storage device are connected over a network. The computing device executes a host application, and its data is stored on the medium. The computing device issues a command to the storage device to be performed on the data. The storage device executes the command and sends the result to the computing device. As a result, the data is not sent to the computing device for manipulation.
摘要:
A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.