公开(公告)号：US20160144079A1

公开(公告)日：2016-05-26

申请号：US14904399

申请日：2014-07-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald INGBER ,  Daniel C. LESLIE ,  Michael SUPER ,  Alexander L. WATTERS ,  Anna WATERHOUSE

IPC: A61L31/08

CPC classification number: A61L31/08 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  B05D5/08 ,  B05D5/086 ,  C09D5/16

Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

Abstract translation: 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有锚定分子，其中每个锚定分子具有与表面共价连接的头基和功能尾组。 锚定分子彼此交联以形成交联网络。 功能尾组对润滑液具有亲和性，润滑液被施加到被处理表面以形成润滑层。 锚定层和补充润滑液通过非共价吸引力保持在一起。 一起，这些层形成一个超疏水滑表面，排斥某些不混溶的液体，并防止其中所含组分的吸附，凝结和表面结垢。

公开(公告)号：US20180298203A1

公开(公告)日：2018-10-18

申请号：US15944619

申请日：2018-04-03

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Benjamin HATTON ,  Donald INGBER ,  Michael SUPER ,  Tak Sing WONG

IPC: C09D5/16 ,  A61L15/42 ,  A61L33/00 ,  F15D1/10 ,  A61L33/06 ,  A61L27/28 ,  A61L27/34 ,  A61L15/46

Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

公开(公告)号：US20160271314A1

公开(公告)日：2016-09-22

申请号：US14921084

申请日：2015-10-23

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald INGBER ,  Shannon XIA ,  Tom P. HUNT ,  Robert WESTERVELT

IPC: A61M1/36 ,  B01L3/00 ,  G01N15/14 ,  B03C1/28

CPC classification number: A61M1/3618 ,  A61M1/36 ,  A61M2205/0244 ,  A61M2206/11 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0668 ,  B01L2300/06 ,  B01L2300/0864 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/1484 ,  G01N2015/149 ,  Y10T436/25375

Abstract: A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.

公开(公告)号：US20200291246A1

公开(公告)日：2020-09-17

申请号：US16780792

申请日：2020-02-03

Applicant: President and Fellows of Harvard College

Inventor： Joanna AIZENBERG ,  Benjamin HATTON ,  Donald INGBER ,  Michael SUPER ,  Tak Sing WONG

IPC: C09D5/16 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00 ,  A61L33/06 ,  F15D1/02 ,  F15D1/10

Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

公开(公告)号：US20190145980A1

公开(公告)日：2019-05-16

申请号：US16092288

申请日：2017-04-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Joo Hun KANG ,  Donald INGBER ,  Michael SUPER ,  Alexander WATTERS ,  Harry DRISCOLL

IPC: G01N33/574 ,  A61K39/00 ,  A61K47/64

Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.

公开(公告)号：US20160311877A1

公开(公告)日：2016-10-27

申请号：US15105298

申请日：2014-12-18

Applicant: Alexander WATTERS ,  Donald INGBER ,  Mark CARTWRIGHT ,  Michael SUPER ,  Martin ROTTMAN ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Alexander WATTERS ,  Donald INGBER ,  Mark CARTWRIGHT ,  Michael SUPER ,  Martin ROTTMAN ,  Evangelina MURRAY ,  Brendon DUSEL

IPC: C07K14/47 ,  A61K47/42 ,  G01N33/569

Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

Abstract translation: 本文描述了工程化的微生物靶向分子，微生物靶向制品，包含其的试剂盒及其用途。 这样的微生物靶向分子，微生物靶向制品或包含其的试剂盒可以结合或捕获其微生物或微生物物质，因此可以用于各种应用中，例如诊断或治疗由微生物引起的感染 主题或任何环境表面。