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    DIGITAL ANALYSIS OF NUCLEIC ACID MODIFICATION
    4.
    发明申请
    DIGITAL ANALYSIS OF NUCLEIC ACID MODIFICATION 审中-公开
    核酸修饰的数字分析

    公开(公告)号：US20150099266A1

    公开(公告)日：2015-04-09

    申请号：US14505974

    申请日：2014-10-03

    Applicant: Raindance Technologies, Inc.

    Inventor： Michael Samuels ,  Jeffrey Olson ,  Darren R. Link

    IPC: G06F19/18 ,  G06F19/00 ,  C12Q1/68

    CPC classification number: G16B20/00

    Abstract: In certain aspects, methods of the invention involve performing modification state specific enzymatic reaction of nucleic acid in a sample, determining a value associated with efficiency of the modification state specific enzymatic reaction based on a control, determining an amount of target nucleic acid in the sample, and normalizing the amount of target nucleic acid based on the efficiency value. Based on the normalized amount of target nucleic acid, the method further includes determining whether the normalized amount of target nucleic acid is indicative of a condition.

    Abstract translation: 在某些方面，本发明的方法涉及在样品中进行核酸的修饰状态特异性酶反应，基于对照确定与修饰状态特异性酶促反应的效率相关的值，确定样品中靶核酸的量 ，并根据效率值使目标核酸的量归一化。 基于目标核酸的归一化量，该方法还包括确定目标核酸的归一化量是否指示条件。

    METHODS FOR ANALYZING DNA
    5.
    发明申请
    METHODS FOR ANALYZING DNA 审中-公开

    公开(公告)号：US20180100185A1

    公开(公告)日：2018-04-12

    申请号：US15835697

    申请日：2017-12-08

    Applicant: Raindance Technologies, Inc.

    Inventor： Michael Samuels

    IPC: C12Q1/686

    Abstract: The invention generally relates to methods for increasing the amount of DNA available for analysis when using partitioned samples and parallel processing. For example, double-stranded DNA can be dissociated into two single-stranded components, and the single strands partitioned into different droplets prior to analysis. The disclosed methods are useful for performing digital PCR analysis on samples where the target DNA is not in abundance, for example when the sample originates from a body fluid or an FFPE sample.

    Methods for analyzing DNA
    7.
    发明授权
    Methods for analyzing DNA 有权

    公开(公告)号：US09840734B2

    公开(公告)日：2017-12-12

    申请号：US14058799

    申请日：2013-10-21

    Applicant: Raindance Technologies, Inc.

    Inventor： Michael Samuels

    IPC: C12Q1/68

    CPC classification number: C12Q1/686 ,  C12Q2527/107 ,  C12Q2535/131 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2565/629

    Abstract: The invention generally relates to methods for increasing the amount of DNA available for analysis when using partitioned samples and parallel processing. For example, double-stranded DNA can be dissociated into two single-stranded components, and the single strands partitioned into different droplets prior to analysis. The disclosed methods are useful for performing digital PCR analysis on samples where the target DNA is not in abundance, for example when the sample originates from a body fluid or an FFPE sample.

    SYSTEM AND METHOD FOR DETECTION OF RNA SPECIES
    9.
    发明申请
    SYSTEM AND METHOD FOR DETECTION OF RNA SPECIES 审中-公开
    用于检测RNA物种的系统和方法

    公开(公告)号：US20150184256A1

    公开(公告)日：2015-07-02

    申请号：US14587365

    申请日：2014-12-31

    Applicant: Raindance Technologies, Inc.

    Inventor： Michael Samuels ,  Darren R. Link ,  Sirshendu Roopom Banerjee

    IPC: C12Q1/70

    CPC classification number: C12Q1/702 ,  C12Q1/70 ,  C12Q2563/159

    Abstract: The invention includes methods for determining the presence of a latent viral population by analyzing an RNA population from the virus with digital techniques, such as digital PCR or by sequencing cDNA produced from the RNA. The invention additional includes methods for determining the presence of latent viral populations by detecting and/or quantifying enzymes that are uniquely associated with the virus, e.g., reverse transcriptases.

    Abstract translation: 本发明包括通过使用数字技术（例如数字PCR）或通过测序从RNA产生的cDNA来分析来自病毒的RNA群体来确定潜伏病毒群体的存在的方法。 本发明另外包括通过检测和/或定量与病毒唯一相关的酶（例如逆转录酶）来确定潜伏病毒种群的存在的方法。

    MOLECULAR DIAGNOSTIC SCREENING ASSAY
    10.
    发明申请
    MOLECULAR DIAGNOSTIC SCREENING ASSAY 审中-公开
    分子诊断筛选测定

    公开(公告)号：US20150126400A1

    公开(公告)日：2015-05-07

    申请号：US14596949

    申请日：2015-01-14

    Applicant: RAINDANCE TECHNOLOGIES, INC.

    Inventor： Andrew Watson ,  Darren R. Link ,  Jeffrey Charles Olson ,  Michael Samuels

    IPC: C12N15/10 ,  C12Q1/68

    CPC classification number: C12N15/1072 ,  C12Q1/6827 ,  C12Q1/6844 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2563/159 ,  C12Q2563/179 ,  C12Q2565/629 ,  C12Q2521/319 ,  C12Q2521/501 ,  C12Q2545/101

    Abstract: The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step.

    Abstract translation: 本发明一般涉及用于筛选受试者的病症的方法。 在某些实施方案中，本发明的方法包括从样品中获得核酸库，将核酸与第一组和第二组结合物孵育，其中第一组与第一组结合到泳池中的靶核酸的不同区域， 第二组与泳池中的参考核酸的不同区域唯一地结合，并且第一组和第二组包括不同的可检测标记，去除未结合的结合物，检测标记，以及基于检测步骤的结果筛选病症。

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