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331 条记录 (耗时 0.041 秒)

    Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
    3.
    发明申请
    Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof 有权
    糖皮质激素模拟物，其制备方法，药物制剂及其用途

    公开(公告)号：US20060030561A1

    公开(公告)日：2006-02-09

    申请号：US11243746

    申请日：2005-10-05

    申请人： Rajashekhar Betageri ,  David Thomson ,  Yan Zhang ,  Renee Zindell

    发明人： Rajashekhar Betageri ,  David Thomson ,  Yan Zhang ,  Renee Zindell

    IPC分类号： A61K31/365 ,  A61K31/538

    CPC分类号： C07D405/12 ,  C07D265/02 ,  C07D307/88

    摘要： A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

    摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4， SUP> 5和R 6如本文所定义，或其互变异构体，前药，溶剂化物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

    Battery case
    4.
    外观设计
    Battery case 有权

    公开(公告)号：USD850373S1

    公开(公告)日：2019-06-04

    申请号：US29675883

    申请日：2019-01-07

    申请人： Yan Zhang

    设计人： Yan Zhang

    Intelligent Pipeline Small Leaks and Thefts Detection Methods and Systems
    5.
    发明申请
    Intelligent Pipeline Small Leaks and Thefts Detection Methods and Systems 审中-公开

    公开(公告)号：US20180246004A1

    公开(公告)日：2018-08-30

    申请号：US15443658

    申请日：2017-02-27

    申请人： Yan Zhang

    发明人： Yan Zhang

    IPC分类号： G01M3/24 ,  G01M3/28

    CPC分类号： G01M3/243 ,  G01M3/2815

    摘要： Four (4) methods and systems that utilize these methods are claimed in the present invention for intelligently detecting pipeline small leaks, thefts, and their details.In the Energy Flow Line Method, the measured flow data at both ends of the pipeline will be monitored and analyzed. If flow changes that meet the criteria are identified, a leak or a theft is detected. The energy wave front speed is introduced and the unsteady flow mathematical model of the subject pipeline is utilized to calculate leak details.In the Filtered Pressure Waves Method, the measured pressure data at both ends of the pipeline will be monitored and analyzed. After filtering, only those pressure waves that are not originated at the ends of the pipeline will be selected as candidates. For each computation step, consecutively apply the 2 travelling time windows template 1 and template 2 to those candidates, and process those candidates within each window. Leaks, thefts and their details (except for leaked amount) can be obtained if the detected leak locations meet the criteria, even when the fluid is stagnant for some time.The Enhanced Filtered Pressure Waves Method, as the name suggests, is the enhanced version of the Filtered Pressure Waves Method if the fluid is not stagnant for some time. The essential part of the Energy Flow Line Method is used to extend the function not only to provide the leaked amount, but also to verify the leak and the leak location in order to avoid sending false alarms. The measured flow data at the outlet end of the pipeline is also monitored and the unsteady flow mathematical model of the subject pipeline is utilized. If the fluid is stagnant for some time, the leaked amount will be calculated without measured data to be compared. The estimated leak location will be provided with a search range.In the Mutual Confirmation Method, essential parts of the above 3 methods are utilized to extend the capability and to confirm each finding. If any result that contradicts the solution is identified, find a new one that fits. By providing the solution that is mutually confirmed with 2 sets of leak details, sending false alarms can be avoided. This method is particularly developed to solve some issues in the real time monitoring applications, especially in SCADA environments, to have shorter calculation time. The unsteady flow mathematical model of the subject pipeline is indispensable for this method. If the fluid is stagnant for some time, the leaked amount will be calculated without measured data to be compared. Also the estimated leak location will be provided with a search range.The present invention is suitable for most pipeline applications, including very long pipelines (for instance, over 200 km), existing pipelines (with min or no modification on existing sensor groups), and pipelines that are shut for some time (excluding using the Energy Flow Line Method), and easily used as a cross checking tool to other pipelines and other online leak detection systems. The fluids in pipelines can be gases, liquids, and multi-phase fluids.

    Fair quantized congestion notification (FQCN) to mitigate transport control protocol (TCP) throughput collapse in data center networks
    8.
    发明授权
    Fair quantized congestion notification (FQCN) to mitigate transport control protocol (TCP) throughput collapse in data center networks 有权
    公平的量化拥塞通知（FQCN），以缓解数据中心网络中的传输控制协议（TCP）吞吐量崩溃

    公开(公告)号：US09237107B2

    公开(公告)日：2016-01-12

    申请号：US13297101

    申请日：2011-11-15

    申请人： Nirwan Ansari ,  Yan Zhang

    发明人： Nirwan Ansari ,  Yan Zhang

    IPC分类号： G06F15/16 ,  H04L12/825 ,  H04L12/835

    CPC分类号： H04L47/263 ,  H04L47/30 ,  Y02D50/10

    摘要： Technologies are generally described for an enhanced Quantized Congestion Notification (QCN) congestion control approach, referred to as Fair QCN (FQCN) for enhancing fairness of multiple flows sharing link capacity in a high bandwidth, low latency data center network. QCN messages may be fed back to flow sources (e.g., servers) which send packets with a sending rate over their share of the bottleneck link capacity. By enabling the flow sources to regulate their data traffic based on the QCN messages from a congestion control component, the queue length at the bottleneck link may converge to an equilibrium queue length rapidly and TCP throughput performance may be enhanced substantially in a TCP incast circumstance.

    摘要翻译： 技术通常被描述用于增强的量化拥塞通知（QCN）拥塞控制方法，称为公平QCN（FQCN），用于增强在高带宽，低延迟数据中心网络中共享链路容量的多个流的公平性。 QCN消息可以被反馈到以发送速率超过其瓶颈链路容量的份额发送分组的流源（例如，服务器）。 通过使流量源能够根据来自拥塞控制组件的QCN消息来调节其数据流量，瓶颈链路上的队列长度可以快速收敛到平衡队列长度，并且TCP吞吐量性能可能在TCP恶劣情况下显着提高。

    Fiber Optic Coupler Array
    9.
    发明申请
    Fiber Optic Coupler Array 有权
    光纤耦合器阵列

    公开(公告)号：US20150316723A1

    公开(公告)日：2015-11-05

    申请号：US14104230

    申请日：2013-12-12

    申请人： Geoff W. Taylor ,  Yan Zhang

    发明人： Geoff W. Taylor ,  Yan Zhang

    IPC分类号： G02B6/30 ,  G02F1/017 ,  G02B6/14 ,  G02B6/122 ,  G02B6/12

    CPC分类号： G02B6/305 ,  G02B6/1228 ,  G02B6/14 ,  G02B6/421 ,  G02B6/423 ,  G02B6/4249 ,  G02B6/4257

    摘要： An assembly includes optical fibers each having a waveguide core, a photonic integrated circuit (IC) that includes in-plane waveguides corresponding to the optical fibers, and a substrate bonded to the photonic IC with grooves that support the optical fibers. The substrate and photonic IC can have metal bumps that cooperate to provide mechanical bonding and electrical connections between the substrate and photonic IC. Portions of the optical fibers supported by the substrate grooves can define flat surfaces spaced from the optical fiber cores. The photonic IC can include passive waveguide structures with a first coupling section that interfaces to the flat surface of a corresponding optical fiber (for evanescent coupling of optical signals) and a second coupling section that interfaces to a corresponding in-plane waveguide (for adiabatic spot-size conversion of optical signals).

    摘要翻译： 一种组件包括各自具有波导芯的光纤，包括对应于光纤的面内波导的光子集成电路（IC）以及与支撑光纤的凹槽连接到光子IC的基板。 衬底和光子IC可以具有金属凸块，其配合以在衬底和光子IC之间提供机械结合和电连接。 由基板槽支撑的光纤的一部分可以限定与光纤芯间隔开的平坦表面。 光子IC可以包括无源波导结构，其具有与对应光纤的平坦表面（用于光信号的渐逝耦合）相接合的第一耦合部分和与对应的平面波导（用于绝热光点）相连接的第二耦合部分 光信号的尺寸转换）。

    System and method for transmission control protocol slow-start
    10.
    发明授权
    System and method for transmission control protocol slow-start 有权
    传输控制协议的启动系统和方法

    公开(公告)号：US09178789B2

    公开(公告)日：2015-11-03

    申请号：US13340354

    申请日：2011-12-29

    申请人： Yan Zhang ,  Nirwan Ansari ,  Mingquan Wu ,  Hong Heather Yu

    发明人： Yan Zhang ,  Nirwan Ansari ,  Mingquan Wu ,  Hong Heather Yu

    IPC分类号： G01R31/08 ,  H04L12/26 ,  H04L12/807 ,  H04L12/801 ,  H04L12/841

    CPC分类号： H04L43/0882 ,  H04L43/16 ,  H04L47/193 ,  H04L47/27 ,  H04L47/283 ,  H04L47/29

    摘要： An embodiment of a system and method that uses inline measurements to probe available bandwidth for a transmission control protocol, and adaptively sets a slow-start threshold according to the available bandwidth. The method includes initializing a congestion window “cwnd,” sending cwnd packets, estimating an available bandwidth for the cwnd packets. The congestion window cwnd is set to a higher number, and the higher number of further packets is sent if the available bandwidth is greater than a first threshold level. The available bandwidth is re-estimated for the higher number of the further packets, and a soft start threshold “ssthresh” is set to the re-estimated available bandwidth. A statistical measure is calculated for the re-estimated available bandwidth, and the congestion window cwnd is set equal to ssthresh if a ratio of the statistical measure to the re-estimated available bandwidth is less than a second threshold level.

    摘要翻译： 使用在线测量来探测传输控制协议的可用带宽的系统和方法的实施例，并且根据可用带宽自适应地设置慢启动阈值。 该方法包括初始化拥塞窗口“cwnd”，发送cwnd数据包，估计cwnd数据包的可用带宽。 拥塞窗口cwnd被设置为更高的数量，并且如果可用带宽大于第一阈值水平，则发送更多数量的另外的分组。 对于更多数量的另外的分组重新估计可用带宽，并且将软启动阈值“ssthresh”设置为重新估计的可用带宽。 对于重新估计的可用带宽计算统计度量，并且如果统计度量与重新估计的可用带宽的比率小于第二阈值水平，则将拥塞窗口cwnd设置为等于ssthresh。