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    VALVE FOR A MICROFLUIDIC SYSTEM
    1.
    发明申请
    VALVE FOR A MICROFLUIDIC SYSTEM 审中-公开
    微流控系统阀

    公开(公告)号：US20100252124A1

    公开(公告)日：2010-10-07

    申请号：US12743838

    申请日：2008-11-18

    申请人： Ralph Kurt ,  Emiel Peeters ,  Roel Penterman ,  Martin Ouwerkerk ,  Christopher James Backhouse

    发明人： Ralph Kurt ,  Emiel Peeters ,  Roel Penterman ,  Martin Ouwerkerk ,  Christopher James Backhouse

    IPC分类号： F16K49/00

    CPC分类号： F16K99/0001 ,  B01L3/502738 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0627 ,  B01L2300/1838 ,  B01L2400/0638 ,  B01L2400/0677 ,  F16K99/0026 ,  F16K99/0044 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N2035/00247 ,  Y10T137/6606

    摘要： The invention relates to a valve for opening and closing a channel (3) of a microfluidic system, respectively. According to the invention, the valve comprises an actuation medium (2) that undergoes a volume change with changing temperature; and a heater arrangement (5) for generating a temperature gradient in the actuation medium (2) with respect to the actuation medium's (2) distance relative to the channel (3); wherein due to an expansion or a contraction of the actuation medium (2) the channel (3) is closed or opened, respectively. When the heater arrangement (5) is activated in such a way that a higher temperature is generated in the actuation medium (2) which is nearer to the channel (3) and a lower temperature is generated in the actuation medium (2) which is further away from the channel (3) the valve can be closed and vice versa. Accordingly, such a valve for a microfluidic system is provided which can be reliably actuated during a long time of use.

    摘要翻译： 本发明涉及分别用于打开和关闭微流体系统的通道（3）的阀。 根据本发明，该阀包括在变化温度下经历体积变化的致动介质（2）; 以及加热器装置（5），用于相对于所述致动介质（2）相对于所述通道（3）的距离产生所述致动介质（2）中的温度梯度; 其中由于致动介质（2）的膨胀或收缩，通道（3）分别关闭或打开。 当加热器装置（5）以这样一种方式启动时，使得在更靠近通道（3）的致动介质（2）中产生较高的温度，并且在致动介质（2）中产生较低的温度 更远离通道（3），阀可以关闭，反之亦然。 因此，提供了这种用于微流体系统的阀，其可以在长时间使用期间被可靠地致动。

    COAXIALLY ENCAPSULATED CELL SUSPENSIONS AND MICROTISSUES
    2.
    发明申请
    COAXIALLY ENCAPSULATED CELL SUSPENSIONS AND MICROTISSUES 审中-公开
    同时包被的细胞悬浮液和微量元素

    公开(公告)号：US20110293712A1

    公开(公告)日：2011-12-01

    申请号：US13132534

    申请日：2009-11-26

    申请人： Ralph Kurt ,  Emiel Peeters ,  Roel Penterman ,  Dirk J. Broer ,  David Halter

    发明人： Ralph Kurt ,  Emiel Peeters ,  Roel Penterman ,  Dirk J. Broer ,  David Halter

    IPC分类号： A61K9/48 ,  A61K35/12 ,  C12M1/00

    CPC分类号： B01J13/04 ,  A61K2035/126 ,  A61L27/38 ,  A61L27/58

    摘要： The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.

    摘要翻译： 本发明提供了在单个细长隔室中的多个电池的同轴封装。 通过这种封装，细胞被至少一层分离材料保护并保持紧密接触，这导致包封的细胞更好的活力，从而导致更高的形成微组织的机会。 在细胞，组织治疗和组织工程中公开了用于生产这种包封的细胞室的方法和装置以及这些隔室的医学用途。

    Patterned cell sheets and a method for production of the same
    5.
    发明授权
    Patterned cell sheets and a method for production of the same 有权
    图案化电池片及其制造方法

    公开(公告)号：US09267109B2

    公开(公告)日：2016-02-23

    申请号：US12746767

    申请日：2008-12-05

    申请人： Emiel Peeters ,  Roel Penterman ,  Ralph Kurt ,  Dirk Jan Wilfred Broer

    发明人： Emiel Peeters ,  Roel Penterman ,  Ralph Kurt ,  Dirk Jan Wilfred Broer

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2535/10 ,  C12N2539/10

    摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.

    摘要翻译： 本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在暴露于脱模剂之后洗涤细胞片以除去已经被脱模剂影响的细胞，并且在第二细胞类型已经去除了已经被脱模剂影响的细胞之后剩余的间隙。