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    Process for improving the color of gemstones and gemstone minerals obtained thereby
    3.
    发明申请
    Process for improving the color of gemstones and gemstone minerals obtained thereby 审中-公开
    改善由此获得的宝石和宝石矿物的颜色的方法

    公开(公告)号：US20070110924A1

    公开(公告)日：2007-05-17

    申请号：US11273475

    申请日：2005-11-14

    申请人： William Yelon ,  Jinbo Yang ,  William James

    发明人： William Yelon ,  Jinbo Yang ,  William James

    IPC分类号： B44F7/00 ,  B32B9/00 ,  B05D3/02

    CPC分类号： C04B41/5072 ,  A44C17/007 ,  A44C27/006 ,  B44F7/00 ,  C04B41/009 ,  C04B2111/82 ,  C23C16/006 ,  C23C16/16 ,  C23C16/18 ,  C04B41/0072 ,  C04B41/4531 ,  C04B14/00

    摘要： New methods of forming color-coated gemstones are provided. These methods broadly comprise subjecting a source of metal (e.g., an organometallic compound) to a vapor deposition process so as to form the metal source into a vapor that is subsequently deposited onto the surface of a previously heated gemstone. The vapor is also diffused into the gemstone so as to form a mixed zone of gemstone having the metal source dispersed or intermixed therein. The coated gemstone is then subjected to heat treatment to alter the valence state of the metal in the coating until the desired colored coating is obtained, resulting in coatings having superior adhesion and optical properties.

    摘要翻译： 提供了形成彩色宝石的新方法。 这些方法广泛地包括使金属源（例如有机金属化合物）经历气相沉积工艺，以便将金属源形成为随后沉积到先前加热的宝石表面上的蒸气。 蒸汽也扩散到宝石中，以形成具有分散或混合在其中的金属源的宝石的混合区域。 然后将涂覆的宝石进行热处理以改变涂层中金属的价态，直到获得所需的着色涂层，导致涂层具有优异的附着力和光学性能。

    Pet waste vacuum
    5.
    发明授权
    Pet waste vacuum 有权

    公开(公告)号：US11274407B1

    公开(公告)日：2022-03-15

    申请号：US16934101

    申请日：2020-07-21

    申请人： William James

    发明人： William James

    IPC分类号： E01H1/12

    摘要： The pet waste vacuum is a vacuum cleaner. The pet waste vacuum is configured for use in picking up the elimination of a companion animal from a surface. The pet waste vacuum incorporates a housing module, a vacuum module, a storage module, a collection module, and a control circuit. The housing contains the vacuum module, the storage module, a collection module, and the control circuit. The storage module is the structure that receives and contains the elimination. The vacuum module provides the motive forces necessary to: a) draw the elimination into the collection module; and, b) move the elimination through the collection module and into the storage module. The control circuit is an electric circuit that: a) controls the operation of the pet waste vacuum; and, b) provides the electrical energy necessary to operate the pet waste vacuum.

    Ligands
    7.
    发明申请
    Ligands 审中-公开
    配体

    公开(公告)号：US20070066547A1

    公开(公告)日：2007-03-22

    申请号：US10534259

    申请日：2003-11-12

    申请人： William James ,  Makobetsa Khati ,  Jamil Ibrahim

    发明人： William James ,  Makobetsa Khati ,  Jamil Ibrahim

    IPC分类号： A61K48/00 ,  C07H21/04

    CPC分类号： C12N15/115 ,  A61K38/00 ,  C12N2310/322

    摘要： Aptamers that bind to viral envelope proteins, in particular those that bind to the envelope glycoprotein gp120 of HIV are disclosed, The use of these aptamers for screening potential therapeutic targets and in the treatment of HIV infections is also described.

    摘要翻译： 公开了结合病毒包膜蛋白，特别是结合HIV的包膜糖蛋白gp120的那些的适配子。还描述了这些适体筛选潜在的治疗靶点和用于治疗HIV感染的用途。

    Intelligent transport system
    8.
    发明授权
    Intelligent transport system 失效
    智能交通系统

    公开(公告)号：US06810817B1

    公开(公告)日：2004-11-02

    申请号：US10081981

    申请日：2002-02-20

    申请人： William James

    发明人： William James

    IPC分类号： B61J300

    CPC分类号： E01B25/22 ,  B61B13/04 ,  B61L23/005 ,  B61L27/04 ,  Y02T30/30 ,  Y02T30/40

    摘要： A public transportation system includes control by highly distributed communications, ultra-light transit vehicles suspended from single or dual rails and powered by electricity. The electric power supplied independently and supplemented by wind generators and solar panels. The transit vehicles, are suitable to transport from one to four persons. The system includes a plurality interconnected rails with main conduits and station conduits to provide non-stop transportation from one station to another station.

    摘要翻译： 公共交通系统包括由高度分布的通信控制，由单轨或双轨悬挂的超轻型交通工具车辆供电。 独立供电并由风力发电机和太阳能电池板补充的电力。 过境车辆适合从一人运送到四人。 该系统包括具有主管道和站管道的多个互连轨道，以提供从一个站点到另一个站点的不间断运输。

    METHODS AND COMPOSITIONS FOR AIDING IN THE DETECTION OF LUNG CANCER
    9.
    发明申请
    METHODS AND COMPOSITIONS FOR AIDING IN THE DETECTION OF LUNG CANCER 审中-公开
    检测肺癌的方法和组成

    公开(公告)号：US20150072890A1

    公开(公告)日：2015-03-12

    申请号：US14483503

    申请日：2014-09-11

    申请人： William James

    发明人： William James

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/178 ,  G01N33/57423 ,  G01N33/57484 ,  G01N2800/50

    摘要： A lung cancer biomarker panel comprising an microRNA (miRNA) lung cancer biomarker and at least one additional lung cancer biomarker selected from a tumor protein (TP) lung cancer biomarker and/or a autoantibody (AAB) lung cancer biomarker is provided herein and methods for screening patients for lung cancer. The present lung cancer biomarker panel provides an improvement in sensitivity and diagnostic accuracy for lung cancer as compared to a lung cancer biomarker panel without the miRNA biomarkers.

    摘要翻译： 本文提供了包含微小RNA（miRNA）肺癌生物标志物和选自肿瘤蛋白（TP）肺癌生物标志物和/或自身抗体（AAB）肺癌生物标志物）的至少一种另外的肺癌生物标志物的肺癌生物标志物组， 筛查肺癌患者。 与没有miRNA生物标志物的肺癌生物标志物组相比，目前的肺癌生物标志物组提供了肺癌的灵敏度和诊断准确度的改善。

    Oligonucleotide-Coated Affinity Membranes and Uses Thereof
    10.
    发明申请
    Oligonucleotide-Coated Affinity Membranes and Uses Thereof 审中-公开
    寡核苷酸包被的亲和膜及其用途

    公开(公告)号：US20110275077A1

    公开(公告)日：2011-11-10

    申请号：US13143935

    申请日：2010-01-11

    申请人： William James ,  Vladimir Rait

    发明人： William James ,  Vladimir Rait

    IPC分类号： C12Q1/68 ,  C08G73/10 ,  C08G64/42 ,  C07H21/00 ,  C08G63/91

    CPC分类号： G01N33/54306 ,  C12Q1/6816 ,  C12Q1/6834 ,  C12Q2565/515 ,  C12Q2563/179

    摘要： A method of analyzing tissue sections in a manner that provides information about the presence and expression levels of multiple biomarkers at each location within the tissue section. The method comprises the preparation of membranes having covalently bound oligonucleotides and the use of those membranes for evaluation of various markers in the sample. The membranes may be arranged in stacks, wherein each layer has a different oligonucleotide capture strand. Transfer oligonucleotides complementary to the capture strands are attached through a cleavable bond to antibodies that recognize and bind to specific biomarkers present in the tissue sample. The tissue sample is exposed to the antibody-transfer strand conjugate and then treated with a cleaving reagent. Upon cleavage, the transfer strand migrates through the stack and binds to the capture strand. The level of expression of the biomarker may be determined by measuring expression of a reporter on the transfer strand.

    摘要翻译： 以提供关于组织部分内的每个位置处的多个生物标志物的存在和表达水平的信息的方式分析组织切片的方法。 该方法包括制备具有共价结合的寡核苷酸的膜，以及使用这些膜评价样品中的各种标记物。 膜可以以堆叠方式布置，其中每层具有不同的寡核苷酸捕获链。 与捕获链互补的转移寡核苷酸通过可切割键连接到识别并结合存在于组织样品中的特异性生物标志物的抗体。 将组织样品暴露于抗体转移链缀合物，然后用切割试剂处理。 在切割时，转移链迁移通过堆叠并结合捕获链。 生物标志物的表达水平可以通过测量转移链上的报告物的表达来确定。