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126 条记录 (耗时 0.034 秒)

    Detecting and treatment of sleep apnea
    3.
    发明申请
    Detecting and treatment of sleep apnea 有权
    检测和治疗睡眠呼吸暂停

    公开(公告)号：US20130197376A1

    公开(公告)日：2013-08-01

    申请号：US13694927

    申请日：2013-01-19

    申请人： Eckhard Alt ,  Maik Gollasch

    发明人： Eckhard Alt ,  Maik Gollasch

    IPC分类号： A61B5/00 ,  A61B5/0205

    CPC分类号： A61B5/4818 ,  A61B5/0205 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/053 ,  A61B5/4836 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36128

    摘要： A device is presented for evaluating whether an episode of sleep apnea is occurring in a patient suffering from chronic sleep apnea disorder, for delivery of appropriate therapy. The device includes circuitry adapted to respond to a cardiac signal generated by the heart. Switching circuitry diverts passage of the heart signal through both a high impedance path and a substantially lower impedance path, and a differential amplifier processes the resulting signal pairs to ascertain the difference in magnitude between the two signals of each pair. An analyzer thereof determines changes in the patient's ventilation, from which inordinately reduced patient ventilation is detected to assess possible occurrence of an episode of sleep apnea. If the analyzer denotes change of ventilation between otherwise regular respiratory cycles, an actual episode of sleep apnea is indicated. A stimulus generator responds to such indication to generate an appropriate electrical therapy for delivery to a preselected location in the patient's body to induce ventilation so as to terminate the apnea episode.

    摘要翻译： 提供了一种用于评估患有慢性睡眠呼吸暂停障碍的患者是否发生睡眠呼吸暂停发作的装置，用于递送适当的治疗。 该装置包括适于响应由心脏产生的心脏信号的电路。 开关电路通过高阻抗路径和基本上较低的阻抗路径转移心脏信号的通过，并且差分放大器处理结果信号对以确定每对信号之间的幅度差异。 其分析仪确定患者通气中的变化，从该位置检测到病人通气不当地减少以评估睡眠呼吸暂停发作的可能发生。 如果分析仪表示在正常呼吸周期之间通气的变化，则表明睡眠呼吸暂停的实际发作。 刺激发生器响应于这种指示以产生适当的电疗法以递送到患者体内的预选位置以诱导通气，以终止呼吸暂停发作。

    Drug-releasing stent with ceramic-containing layer
    4.
    发明授权
    Drug-releasing stent with ceramic-containing layer 有权
    药物释放支架含陶瓷层

    公开(公告)号：US08066763B2

    公开(公告)日：2011-11-29

    申请号：US12777705

    申请日：2010-05-11

    申请人： Eckhard Alt

    发明人： Eckhard Alt

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2230/005 ,  A61F2250/0098 ,  A61F2310/00598 ,  A61F2310/0088 ,  A61L31/022 ,  A61L31/082 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2420/08

    摘要： A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen. The stent includes a base layer of a biologically compatible metal. An intermediate metal particle layer of substantial greater radiopacity overlies the base layer, with particles bonded to the base layer and to each other to leave interstices therebetween as a repository for retaining and dispensing drugs or other agents for time release therefrom. The particles are composed primarily of a noble metal. Exposed surfaces of the particle layer are coated with ceramic-like iridium oxide or titanium nitrate, as a biocompatible material to inhibit irritation of tissue at the inner lining of the vessel when the stent is implanted.

    摘要翻译： 血管或腔内支架适于植入人体的容器，管道或管道中以维持开放的内腔。 支架包括生物相容性金属的基层。 具有相当大的辐射不透性的中间金属颗粒层覆盖基层，其中颗粒结合到基层和彼此之间以在其间留下间隙，作为用于保留和分配药物或其它试剂以便及时释放的储存库。 颗粒主要由贵金属组成。 当植入支架时，颗粒层的暴露表面涂覆有陶瓷状氧化铱或硝酸钛作为生物相容性材料，以抑制容器内衬层对组织的刺激。

    DEVICE FOR CONNECTING TWO BLOOD VESSELS
    6.
    发明申请
    DEVICE FOR CONNECTING TWO BLOOD VESSELS 失效
    用于连接两个血管的装置

    公开(公告)号：US20100324653A1

    公开(公告)日：2010-12-23

    申请号：US12599627

    申请日：2008-05-07

    申请人： Nicola Rubenstein ,  Eckhard Alt

    发明人： Nicola Rubenstein ,  Eckhard Alt

    IPC分类号： A61F2/82

    CPC分类号： A61B17/11 ,  A61B2017/00477 ,  A61B2017/00867 ,  A61B2017/1107 ,  A61B2017/1132

    摘要： A device for connecting abutting ends (1) of two blood vessels (2) that will be continuous after being mutually connected (anastomosis), the device primarily and substantially including a supporting part (3) that can be inserted in the two ends (1) of the blood vessel (2) to be connected, made, for example, of plastic or metal, particularly in the form of a mesh, grid, or cage. The supporting part (3) can be inserted into the blood vessels (1) far enough that the faces (4) of the blood vessel ends (1) can be brought into contact with each other and are in contact with each other in the usage position. The outer cross-section of the supporting part (3) in the usage position is thereby approximately the same as the inner cross-section of the blood vessel (1) in question and has an inner pass-through cross-section (lumen), so that blood can flow unhindered, but the blood vessels (1) in contact with each other are fixed at the same height to each other on the inside, and secured against sideways deflection relative to each other or sideways deflection of the blood vessel walls. The supporting part (3) can be made from one or two pieces.

    摘要翻译： 一种用于连接在相互连接（吻合）后将连续的两个血管（2）的邻接端（1）的装置，该装置主要并且基本上包括可插入两端（1）中的支撑部分（3） ）连接的血管（2），例如由塑料或金属制成，特别是网格，网格或笼子的形式。 支撑部分（3）可以插入到血管（1）中足够远以使血管端部（1）的表面（4）彼此接触并且在使用中彼此接触 位置。 因此，使用位置中的支撑部（3）的外侧截面大致与所述血管（1）的内侧截面相同，并且具有内侧贯通截面（内腔） 使得血液不受阻碍地流动，但是彼此接触的血管（1）在内侧彼此相同的高度固定，并且被抵抗横向相对于彼此的偏转或血管壁的侧向偏转。 支撑部件（3）可以由一个或两个制成。

    DRUG-RELEASING STENT WITH CERAMIC-CONTAINING LAYER
    7.
    发明申请
    DRUG-RELEASING STENT WITH CERAMIC-CONTAINING LAYER 有权
    含有陶瓷层的药物释放支架

    公开(公告)号：US20100286763A1

    公开(公告)日：2010-11-11

    申请号：US12777705

    申请日：2010-05-11

    申请人： Eckhard Alt

    发明人： Eckhard Alt

    IPC分类号： A61F2/82

    CPC分类号： A61F2/06 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2230/005 ,  A61F2250/0098 ,  A61F2310/00598 ,  A61F2310/0088 ,  A61L31/022 ,  A61L31/082 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2420/08

    摘要： A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen. The stent includes a base layer of a biologically compatible metal. An intermediate metal particle layer of substantial greater radiopacity overlies the base layer, with particles bonded to the base layer and to each other to leave interstices therebetween as a repository for retaining and dispensing drugs or other agents for time release therefrom. The particles are composed primarily of a noble metal. Exposed surfaces of the particle layer are coated with ceramic-like iridium oxide or titanium nitrate, as a biocompatible material to inhibit irritation of tissue at the inner lining of the vessel when the stent is implanted.

    摘要翻译： 血管或腔内支架适于植入人体的容器，管道或管道中以维持开放的内腔。 支架包括生物相容性金属的基层。 具有相当大的辐射不透性的中间金属颗粒层覆盖基层，其中颗粒结合到基层和彼此之间以在其间留下间隙，作为用于保留和分配药物或其它试剂以便及时释放的储存库。 颗粒主要由贵金属组成。 当植入支架时，颗粒层的暴露表面涂覆有陶瓷状氧化铱或硝酸钛作为生物相容性材料，以抑制容器内衬层对组织的刺激。

    Primarily niobium stent
    8.
    发明授权
    Primarily niobium stent 失效
    主要是铌支架

    公开(公告)号：US07604703B2

    公开(公告)日：2009-10-20

    申请号：US11417856

    申请日：2006-05-03

    申请人： Torsten Scheuermann ,  Eckhard Alt

    发明人： Torsten Scheuermann ,  Eckhard Alt

    IPC分类号： C23C8/06 ,  A61F2/06 ,  C22F1/18

    CPC分类号： A61L31/18 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2310/00598 ,  A61L31/022 ,  A61L31/088

    摘要： In a process of fabricating a stent composed primarily of niobium alloyed with a trace amount of zirconium, tantalum, or titanium for hardening, the stent is annealed under vacuum in a substantially oxygen-free environment. The vacuum is preferably maintained at pressure less than 10−4 millibars, oxygen-content less than about 80 parts per million, and the annealing temperature exceeds 400° C. for at least one hour, and is preferably kept in a range from about 1100-1200° C. for several hours. This may be followed by applying a surface layer of oxide, such as iridium oxide, with a thickness of 299-300 nm to the stent.

    摘要翻译： 在制造主要由铌合金化的用于硬化的锆，钽或钛的支架的制造过程中，支架在基本上无氧的环境中在真空下退火。 真空优选保持在小于10-4毫巴的压力，含氧量小于约百万分之八十，退火温度超过400℃至少一小时，优选保持在约1100 -1200℃几个小时。 然后可以向支架施加厚度为299-300nm的氧化物表面层，例如氧化铱。

    Tubular stent with oval struts
    10.
    发明申请
    Tubular stent with oval struts 失效
    管状支架带椭圆形支柱

    公开(公告)号：US20070010870A1

    公开(公告)日：2007-01-11

    申请号：US11505640

    申请日：2006-08-17

    申请人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alert ,  Axel Stemberger

    发明人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alert ,  Axel Stemberger

    IPC分类号： A61F2/06

    CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2240/001 ,  A61F2250/0036 ,  A61F2250/0098 ,  C21D1/773 ,  Y10S623/901

    摘要： An expandable tubular endoluminal prosthesis for maintaining the patency of a bodily vessel has a plurality of axially spaced serpentine bands. Each serpentine band has a proximal and distal end and a plurality of interconnected struts. Serpentine bands which are adjacent one another are connected one to the other. The prosthesis has a flow path therethrough and is capable of radial outward expansion from a first diameter to a second enlarged diameter. In a cross-section perpendicular to the flowpath, the struts have thicker portions with a narrower portion therebetween and have a greater width than thickness.

    摘要翻译： 用于维持身体血管通畅的可扩张管状腔内假体具有多个轴向间隔开的蛇形带。 每个蛇形带具有近端和远端以及多个相互连接的支柱。 彼此相邻的蛇形带彼此连接。 假体具有穿过其的流动路径，并且能够从第一直径向第二扩大直径的径向向外膨胀。 在垂直于流路的横截面中，支柱具有较厚部分，其间具有较窄部分，并且具有比厚度更大的宽度。