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    Sophorolipids as protein inducers and inhibitors in fermentation medium
    2.
    发明授权
    Sophorolipids as protein inducers and inhibitors in fermentation medium 有权
    作为发酵培养基中的蛋白质诱导剂和抑制剂

    公开(公告)号：US09012194B2

    公开(公告)日：2015-04-21

    申请号：US11722356

    申请日：2005-12-22

    申请人： Richard A. Gross ,  Vishal Shah ,  Frantisek Nerud ,  Datta Madamwars

    发明人： Richard A. Gross ,  Vishal Shah ,  Frantisek Nerud ,  Datta Madamwars

    IPC分类号： C12P21/00 ,  C12P19/44 ,  C12P19/62

    CPC分类号： C12P19/44 ,  C12P19/62 ,  C12P21/00

    摘要： A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.

    摘要翻译： 一种制备具有蛋白诱导剂和/或阻遏物活性的槐糖脂的方法，其具有以下步骤：通过在发酵培养基中发酵假丝酵母发酵来合成槐糖脂，以形成天然槐糖脂和非内酰槐糖的天然混合物，然后将天然混合物用作 蛋白质诱导剂，利用天然混合物作为蛋白质抑制剂，和/或利用天然混合物作为组合的蛋白质诱导/抑制剂。 根据该方法生产的槐糖脂化合物作为微生物培养基成分的应用。

    Production of an α-carboxyl-ω-hydroxy fatty acid using a genetically modified Candida strain
    3.
    发明授权
    Production of an α-carboxyl-ω-hydroxy fatty acid using a genetically modified Candida strain 有权
    使用遗传修饰的假丝酵母菌株生产α-羧基-ω-羟基脂肪酸

    公开(公告)号：US08158391B2

    公开(公告)日：2012-04-17

    申请号：US12436729

    申请日：2009-05-06

    申请人： Richard A. Gross ,  Wenhua Lu ,  Jon Ness ,  Jeremy Minshull

    发明人： Richard A. Gross ,  Wenhua Lu ,  Jon Ness ,  Jeremy Minshull

    IPC分类号： C12P7/64 ,  C12N9/00 ,  C12N1/00 ,  C12N15/00 ,  C12N15/74

    CPC分类号： C12P7/6427 ,  C12N9/0006 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409

    摘要： A substantially pure Candida host cell for the production of a α-carboxyl-ω-hydroxy fatty acid having a carbon chain length in the range from C6 to C22, a α,ω-dicarboxylic fatty acid having a carbon chain length in the range from C6 to C22, or mixtures thereof, is provided. The Candida host cell is characterized by a first genetic modification class and a second genetic modification class. The first genetic modification class comprises one or more genetic modifications that disrupt the peroxisomal β-oxidation pathway. The second genetic modification class comprises one or more genetic modifications that collectively or individually disrupt at least one gene selected from the group consisting of a CYP52A type cytochrome P450, a fatty alcohol oxidase, and an alcohol dehydrogenase.

    摘要翻译： 用于生产碳链长度在C6至C22范围内的α-羧基-ω-羟基脂肪酸的基本上纯的假丝酵母宿主细胞，具有碳链长度范围的α，ω-二羧酸脂肪酸 C6至C22，或其混合物。 念珠菌宿主细胞的特征在于第一遗传修饰类和第二遗传修饰类。 第一种遗传修饰类包括一种或多种破坏过氧化物酶体和氧化途径的遗传修饰。 第二遗传修饰类包括共同或单独破坏选自CYP52A型细胞色素P450，脂肪醇氧化酶和醇脱氢酶中的至少一种基因的一种或多种遗传修饰。

    SPERMICIDAL AND VIRUCIDAL PROPERTIES OF VARIOUS FORMS OF SOPHOROLIPIDS
    6.
    发明申请
    SPERMICIDAL AND VIRUCIDAL PROPERTIES OF VARIOUS FORMS OF SOPHOROLIPIDS 审中-公开
    各种形式的杀虫剂的防腐和防腐性能

    公开(公告)号：US20110223239A1

    公开(公告)日：2011-09-15

    申请号：US13112122

    申请日：2011-05-20

    申请人： Richard A. Gross ,  Vishal Shah ,  Gustavo F. Doncel

    发明人： Richard A. Gross ,  Vishal Shah ,  Gustavo F. Doncel

    IPC分类号： A61K31/7028 ,  A61K9/127 ,  A61P15/16 ,  A61P31/18

    CPC分类号： A61K31/704 ,  A61K36/062 ,  A61K45/06 ,  C07H15/24 ,  C12P19/44 ,  A61K2300/00

    摘要： A method for inactivating spermatozoa, neutralizing or inactivating a virus, and neutralizing or inactivating HIV using sophorolipids having spermicidal and/or antiviral properties produced by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.

    摘要翻译： 一种灭活精子，中和或灭活病毒的方法，以及使用具有杀精和/或抗病毒性质的槐糖脂中和或灭活的方法，其通过在发酵培养基中通过发酵假丝酵母发酵来合成槐糖脂，以形成内酯槐糖脂化合物的天然混合物和 非内酯槐糖脂化合物，并将天然混合物用作杀精和/或抗病毒剂，和/或从天然混合物中分离内酯槐糖脂以形成内酯级分，并混合所有剩余部分以形成非内酯级分并利用 内酯级分和/或非内酯级分作为杀精和/或抗病毒剂，以及用作杀精和/或抗病毒剂的槐糖脂化合物。

    SPERMICIDAL AND VIRUCIDAL PROPERTIES OF VARIOUS FORMS OF SOPHOROLIPIDS
    7.
    发明申请
    SPERMICIDAL AND VIRUCIDAL PROPERTIES OF VARIOUS FORMS OF SOPHOROLIPIDS 审中-公开
    各种形式的杀虫剂的防腐和防腐性能

    公开(公告)号：US20110217344A1

    公开(公告)日：2011-09-08

    申请号：US13112144

    申请日：2011-05-20

    申请人： Richard A. Gross ,  Vishal Shah ,  Gustavo F. Doncel

    发明人： Richard A. Gross ,  Vishal Shah ,  Gustavo F. Doncel

    IPC分类号： A61K31/7028 ,  C07H15/06 ,  A61K9/00 ,  A61P31/12 ,  A61P15/18

    CPC分类号： A61K31/704 ,  A61K36/062 ,  A61K45/06 ,  C07H15/24 ,  C12P19/44 ,  A61K2300/00

    摘要： Sophorolipid compounds having spermicidal and/or antiviral properties prepared by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.

    摘要翻译： 通过在发酵培养基中发酵假丝酵母合成槐糖脂制备具有杀精和/或抗病毒性质的槐糖脂化合物，以形成内酯槐糖脂化合物和非内酯槐糖脂化合物的天然混合物，并将该天然混合物用作杀精和/或抗病毒 试剂和/或从天然混合物中分离内酯槐糖脂以形成内酯级分，并混合所有剩余部分以形成非内酯级分，并利用内酯级分和/或非内酯级分作为杀精和/或抗病毒 药剂和槐糖脂化合物，用作杀精和/或抗病毒剂。

    METHOD FOR NEUTRALIZING FUNGI USING SOPHOROLIPIDS AND ANTIFUNGAL SOPHOROLIPIDS FOR USE THEREIN
    10.
    发明申请
    METHOD FOR NEUTRALIZING FUNGI USING SOPHOROLIPIDS AND ANTIFUNGAL SOPHOROLIPIDS FOR USE THEREIN 有权
    使用异戊酸和抗真菌SOPHOROLIPER使用真菌中和真菌的方法

    公开(公告)号：US20090186836A1

    公开(公告)日：2009-07-23

    申请号：US12360486

    申请日：2009-01-27

    申请人： Richard A. Gross ,  Vishal Shah

    发明人： Richard A. Gross ,  Vishal Shah

    IPC分类号： A01N43/16 ,  A01P3/00

    CPC分类号： C12P7/62 ,  A61K31/7024 ,  C12P19/44 ,  C12P19/62

    摘要： 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octa-decenoate, lactonic and open ring 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, methyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, hexyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate, ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6″-acetate and ethyl 17-L-[(2′-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6′,6″-diacetate sophorolipids and uses thereof as antifungal agents.

    摘要翻译： 17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-八氢癸酸酯，内酯和开环17-L - [（2'-O- β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸甲酯，17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] 顺式-9-十八烯酸乙酯，17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸乙酯，17-L - [（2'- O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸乙酯，17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） ] - 顺式-9-十八碳烯酸酯-6“ - 乙酸酯和17-L - [（2'-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） - 氧基] - 顺式-9-十八碳烯酸酯-6' ，6“ - 二乙酸槐糖脂及其用作抗真菌剂。