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公开(公告)号:US20070105860A1
公开(公告)日:2007-05-10
申请号:US11556285
申请日:2006-11-03
申请人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Stephen Flack , Dramane Laine , Ann Walker
发明人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Stephen Flack , Dramane Laine , Ann Walker
IPC分类号: A61K31/5375 , A61K31/496 , A61K31/47 , A61K31/445
CPC分类号: C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D261/18 , C07D307/46 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12
摘要: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)化合物或其药学上可接受的盐或溶剂合物,以及它们作为药物的用途,特别是作为p38激酶抑制剂。
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公开(公告)号:US20050020540A1
公开(公告)日:2005-01-27
申请号:US10492697
申请日:2002-10-16
申请人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Stephen Flack , Dramane Laine , Ann Walker
发明人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Stephen Flack , Dramane Laine , Ann Walker
IPC分类号: A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/5377 , A61P1/04 , A61P3/10 , A61P7/02 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/14 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/18 , A61P33/06 , A61P35/00 , A61P37/04 , A61P37/08 , A61P39/02 , C07D213/81 , C07D233/64 , C07D261/18 , C07D307/46 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D521/00 , A61K31/695
CPC分类号: C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D261/18 , C07D307/46 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12
摘要: Compounds of formula (I): or pharmaceutically acceptable sats or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)化合物或其药学上可接受的饱和或溶剂化物,及其作为药物的用途,特别是作为p38激酶抑制剂。
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公开(公告)号:US20070142476A1
公开(公告)日:2007-06-21
申请号:US11669219
申请日:2007-01-31
申请人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Stephen Flack , Dramane Laine , Ann Walker
发明人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Stephen Flack , Dramane Laine , Ann Walker
IPC分类号: A61K31/165 , C07C237/22
CPC分类号: C07D213/81 , C07D261/18 , C07D307/68 , C07D333/38 , C07D401/12
摘要: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)化合物或其药学上可接受的盐或溶剂合物,以及它们作为药物的用途,特别是作为p38激酶抑制剂。
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4.5'-carbamoyl-1,1' biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors 失效
标题翻译: 5'-氨基甲酰基-1,1'-联苯-4-甲酰胺衍生物及其作为p38激酶抑制剂的用途公开(公告)号:US20050038014A1
公开(公告)日:2005-02-17
申请号:US10492699
申请日:2002-10-16
申请人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Suzanne Merrick , Ann Walker
发明人: Richard Angell , Nicola Aston , Paul Bamborough , Mark Bamford , George Cockerill , Suzanne Merrick , Ann Walker
IPC分类号: C07D295/12 , A61K31/341 , A61K31/40 , A61K31/417 , A61K31/4174 , A61K31/426 , A61K31/435 , A61K31/4409 , A61K31/495 , A61K31/5375 , A61P1/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/04 , A61P33/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D211/26 , C07D213/40 , C07D233/61 , C07D233/64 , C07D277/28 , C07D295/13 , C07D295/135 , C07D295/16 , C07D295/182 , C07D307/14 , C07D307/52 , C07D307/66 , C07D521/00 , A61K31/55 , A61K31/445
CPC分类号: C07D295/182 , C07D211/26 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/52
摘要: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)化合物或其药学上可接受的盐或溶剂合物,以及它们作为药物的用途,特别是作为p38激酶抑制剂。
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5.2'-Methyl-5'-(1,3,4-Oxadiazol-2-yl)-1,1'-Biphenyl-4-Carboxamide Derivatives and Their Use As P38 Kinase Inhibitors 审中-公开
标题翻译: 2'-甲基-5' - (1,3,4-恶二唑-2-基)-1,1'-联苯-4-甲酰胺衍生物及其作为P38激酶抑制剂的用途公开(公告)号:US20070112046A1
公开(公告)日:2007-05-17
申请号:US11557607
申请日:2006-11-08
申请人: Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
发明人: Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
IPC分类号: A61K31/4245 , C07D271/12
CPC分类号: C07D271/10
摘要: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)化合物或其药学上可接受的盐或溶剂合物,以及它们作为药物的用途,特别是作为p38激酶抑制剂。
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6.2'-Methyl-5'-(1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors 失效
标题翻译: 2'-甲基-5' - (1,3,4-恶二唑-2-基)-1,1'-联苯-4-甲酰胺衍生物及其作为p38激酶抑制剂的用途公开(公告)号:US20050090491A1
公开(公告)日:2005-04-28
申请号:US10492497
申请日:2002-10-16
申请人: Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
发明人: Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
IPC分类号: A61K31/4245 , A61P1/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/04 , A61P31/06 , A61P31/18 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D271/10 , C07D417/02 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D413/02
CPC分类号: C07D271/10
摘要: Compounds of formula (I) wherein when m is 0 to 4 R1 is selected from C1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, —SO2NR4R5, —CONR4R5 and —COOR4; and when m is 2 to 4 R1 is additionally selected from C1-6alkoxy, hydroxy, NR4R5, —NR4SO2R5, —NR4SOR5, —NR4COR5, and —NR4CONR4R5; R2 is selected from hydrogen, C1-6alkyl and —(CH2)n—C3-7cycloalkyl; R3 is the group R6 is selected from hydrogen and C1-4alkyl; U is selected from methyl and halogen; X and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be optionally substituted with one or two groups selected independently from C1-6alkyl; n is selected from 0, 1, 2 and 3; r is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)的化合物,其中当m为0至4时R 1选自C 1-6烷基,C 3-7环烷基,C 2-6烯基,-SO 2 NR 4 R 5,-CONR 4 R 5和-COOR 4; 当m为2至4时,R1另外选自C1-6烷氧基,羟基,NR4R5,-NR4SO2R5,-NR4SOR5,-NR4COR5和-NR4CONR4R5; R2选自氢,C1-6烷基和 - (CH2)n-C3-7环烷基; R3为基团R6选自氢和C1-4烷基; U选自甲基和卤素; X和Y各自独立地选自氢,甲基和卤素; m选自0,1,2,3和4,其中所得碳链的每个碳原子可以任选被一个或两个独立地选自C 1-6烷基的基团取代; n选自0,1,2和3; r选自0,1和2; 或其药学上可接受的盐或溶剂化物,以及它们作为药物的用途,特别是作为p38激酶抑制剂。
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7.Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors 审中-公开
标题翻译: 恶二唑基 - 联苯甲酰胺及其作为p38激酶抑制剂的用途公开(公告)号:US20050065195A1
公开(公告)日:2005-03-24
申请号:US10492711
申请日:2002-10-16
申请人: Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
发明人: Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
IPC分类号: A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P1/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/18 , A61P33/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D271/10 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/195 , A61K31/277 , A61K31/4172
CPC分类号: C07D271/10 , C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12 , C07D417/12
摘要: Compounds of formula (I), wherein R3 is the group; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)的化合物,其中R 3为基团; 或其药学上可接受的盐或溶剂化物,以及它们作为药物的用途,特别是作为p38激酶抑制剂。
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公开(公告)号:US20070129354A1
公开(公告)日:2007-06-07
申请号:US10551502
申请日:2004-04-07
申请人: Nicola Aston , Paul Bamborough , Katherine Jones , Vipulkumar Patel , Stephen Swanson , Ann Walker
发明人: Nicola Aston , Paul Bamborough , Katherine Jones , Vipulkumar Patel , Stephen Swanson , Ann Walker
IPC分类号: A61K31/54 , A61K31/5377 , A61K31/495 , A61K31/445 , A61K31/426 , A61K31/421 , A61K31/4164 , A61K31/40 , A61K31/165
CPC分类号: C07D271/06 , C07C235/42 , C07C235/46 , C07C237/30 , C07C237/42 , C07C275/42 , C07C311/04 , C07C311/15 , C07C2601/02 , C07D295/088 , C07D295/185
摘要: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译: 式(I)化合物或其药学上可接受的衍生物及其作为药物的用途,特别是作为p38激酶抑制剂。
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公开(公告)号:US20060276516A1
公开(公告)日:2006-12-07
申请号:US11462858
申请日:2006-08-07
申请人: Nicola Aston , Paul Bamborough , Ann Walker
发明人: Nicola Aston , Paul Bamborough , Ann Walker
IPC分类号: A61K31/455 , C07D213/46
CPC分类号: C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译: 式(I)化合物:p38激酶的抑制剂,可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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公开(公告)号:US20050176964A1
公开(公告)日:2005-08-11
申请号:US10503968
申请日:2003-02-10
申请人: Nicola Aston , Paul Bamborough , Ann Walker
发明人: Nicola Aston , Paul Bamborough , Ann Walker
IPC分类号: A61K20060101 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/496 , A61P20060101 , A61P3/10 , A61P7/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/04 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/06 , A61P31/18 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D20060101 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12 , C07D211/82 , C07D213/46 , C07D41/02
CPC分类号: C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译: 式(I)化合物:p38激酶的抑制剂,可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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