摘要:
By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for expression of its pharmacological actions. Therefore, the compound of the present invention is useful as a therapeutic and/or prophylactic agent for diseases caused by thrombus formation.
摘要:
By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for expression of its pharmacological actions. Therefore, the compound of the present invention is useful as a therapeutic and/or prophylactic agent for diseases caused by thrombus formation.
摘要:
A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]
摘要:
A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen.
摘要:
A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]
摘要翻译:由以下通式(1)表示的化合物,其盐或其前体的水合物是可用于治疗和/或预防与血栓形成有关的疾病的新型化合物,其具有合适的理化稳定性更安全。 [其中R 1a,R 1b,R 1c和R 1d各自独立地表示氢等。 R 2表示任选取代的苯基等; R 3表示任选取代的C 6-10芳基等; Z 1和Z 2各自独立地表示氢]
摘要:
A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen.
摘要:
A Compound represented by the following general formula (1): wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen or salts thereof or hydrates of the foregoing.
摘要翻译:由以下通式(1)表示的化合物:其中R1a,R1b,R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R 3表示任选取代的C 6-10芳基等; 并且Z 1和Z 2各自独立地表示氢或其盐或前述的水合物。
摘要:
A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.
摘要翻译:由下列通式(1)表示的化合物或其盐或其水合物是安全的,同时具有合适的物理化学稳定性,并且可用作与血栓形成相关的疾病的治疗或预防剂。 其中R 1a,R 1b,R 1c和R 1d各自独立地表示氢等, O 2表示任选取代的苯基等,R 3表示任选取代的C 6-10芳基等,Z 1,Z 2, Z 3和Z 3各自独立地表示氢等,Z 4表示氢等,X表示单键或-CO-等。
摘要:
Regarding an engine exhaust gas heat exchanger that allows exhaust gas to collide with a coolant passage through apertures, a configuration that can improve efficiency of heat exchange is provided. The engine exhaust gas heat exchanger 1 is provided with multiple stages of unit exhaust gas passages 3a, 3b, 3c that are configured with a first exhaust gas passage A in which a plane facing an inlet is blocked and that has a plurality of apertures 30 in a circumferential direction and in a flow direction, and a second exhaust gas passage B that has a dividing wall facing the apertures 30 and also serving as the coolant passage 20 and an outlet that also serves as an inlet of the first exhaust gas passage A of a next stage or an outlet 26 of the engine exhaust gas heat exchanger 1.
摘要:
An information input device is provided which is to make input of information by operating a disk-shaped rotating member. The device includes the rotating member (36) which is rotatable with one main side thereof being operated, rotation detecting means (23, 32) for detecting a rotation of the rotating member (36), a central switch activator (26) provided at the center of rotation of the rotating member (36), a central switch (270) which is activated by operating the central switch activator (26), and a plurality of peripheral switches (27) which are turned on when a portion, apart from the center of rotation, of the rotating member (36) is pressed. Rotating the rotating member and pressing the apart portion makes input of information, and operating the central switch activator sets the information thus entered.