公开(公告)号：US06448274B2

公开(公告)日：2002-09-10

申请号：US09864943

申请日：2001-05-24

申请人： Richard Friesen ,  Yves Ducharme ,  Yves Girard ,  Chun Li ,  Annette Robichoud

发明人： Richard Friesen ,  Yves Ducharme ,  Yves Girard ,  Chun Li ,  Annette Robichoud

IPC分类号： A61K3144

CPC分类号： C07D213/89

摘要： A PDE4 inhibiting compound is represented by

摘要翻译： PDE4抑制化合物由下式表示

公开(公告)号：US06204275B1

公开(公告)日：2001-03-20

申请号：US09513149

申请日：2000-02-25

申请人： Richard Friesen ,  Yvbes Ducharme ,  Daniel Dube ,  Yves Girard ,  Richard Frenette ,  Chun Li ,  Marc Blouin ,  Nathalie Chauret ,  Laird Trimble

发明人： Richard Friesen ,  Yvbes Ducharme ,  Daniel Dube ,  Yves Girard ,  Richard Frenette ,  Chun Li ,  Marc Blouin ,  Nathalie Chauret ,  Laird Trimble

IPC分类号： C07D40102

CPC分类号： C07D213/30 ,  C07D213/89 ,  C07D417/14

摘要： The invention encompasses compounds of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.

摘要翻译： 本发明包括通过抑制磷酸二酯酶IV（PDE IV）提高环腺苷-3'，5'-单磷酸（cAMP）的水平，可用于治疗疾病（包括哮喘）的式I化合物。本发明还包括 通过抑制PDE IV治疗疾病的某些药物组合物和方法，导致cAMP升高，包括使用式I化合物。

公开(公告)号：US06677351B2

公开(公告)日：2004-01-13

申请号：US10154591

申请日：2002-05-24

申请人： Chun Li ,  Mario Girard ,  Pierre Hamel ,  Sebastien Laliberte ,  Richard Friesen ,  Yves Girard ,  Daniel Guay

发明人： Chun Li ,  Mario Girard ,  Pierre Hamel ,  Sebastien Laliberte ,  Richard Friesen ,  Yves Girard ,  Daniel Guay

IPC分类号： A61K31444

CPC分类号： C07D471/04

摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterrase 4 inhibitors useful in the treatment of asthma and inflammation.

摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是可用于治疗哮喘和炎症的磷酸二酯酶4抑制剂。

公开(公告)号：US09257225B2

公开(公告)日：2016-02-09

申请号：US12166322

申请日：2008-07-02

申请人： Chun Li ,  Jason (Jian Hao) Li ,  Ran Ran Li

发明人： Chun Li ,  Jason (Jian Hao) Li ,  Ran Ran Li

IPC分类号： H01F21/04 ,  H01F27/28 ,  H01F21/02 ,  H01F27/38 ,  H01F3/12 ,  H01F38/16

CPC分类号： H01F27/385 ,  H01F3/12 ,  H01F38/16

摘要： The LC combined transformer is a combination of capacitors, inductors and an electrically-isolated mutual inductor, i.e. conventional transformer; which in principle is a unity-coupled mutual capacitor or a cascade connection of an ideal transformer and unity-coupled mutual capacitor(s). To improve the imperfections of widely-used transformers, by employing the simplest passive-circuit design to attain a perfectly-functional match between mutual capacitors and the mutual inductor, this invention achieves optimal features of current or/and voltage transformation, and introduces a new function of waveform conversion from square to quasi-sine. The ideal current transformer herein is suitable for sinusoidal current measurements, the ideal voltage transformer herein suitable for sinusoidal voltage measurements, and they also could be upgraded to ideal transformers for both current and voltage transformations. This transformer can be designed as power transferable as well as waveform convertible, applicable in power systems or power electronics. Herein also states the design approach of integrated inductor and mutual inductor, and the use of push-pull inductor, materials being fully utilized and sizes decreased.

摘要翻译： LC组合变压器是电容器，电感器和电隔离互感器的组合，即常规变压器; 其原理上是单相耦合互电容器或理想变压器和单相耦合互电容器的级联连接。 为了改善广泛使用的变压器的缺陷，通过采用最简单的无源电路设计，实现互电容和互感器之间的完美功能匹配，本发明实现了电流或/和电压转换的最佳特性，并引入了新的 从正方形到准正弦的波形转换功能。 本文中理想的电流互感器适用于正弦电流测量，本文中的理想电压互感器适用于正弦电压测量，并且还可升级为用于电流和电压转换的理想变压器。 该变压器可以设计为可转换的以及波形转换，适用于电力系统或电力电子设备。 这里还介绍了集成电感和互感器的设计方法，以及推挽式电感器的使用，充分利用材料和尺寸减小。

公开(公告)号：US09089288B2

公开(公告)日：2015-07-28

申请号：US13436991

申请日：2012-04-01

申请人： Jia You ,  Qin Li ,  Zhenhua Guo ,  Qiang Sun ,  Chun Li

发明人： Jia You ,  Qin Li ,  Zhenhua Guo ,  Qiang Sun ,  Chun Li

IPC分类号： G06K9/00 ,  A61B3/12 ,  G06K9/46 ,  G06T7/00 ,  G06K9/36

CPC分类号： A61B3/12 ,  G06K9/00597 ,  G06K9/0061 ,  G06K9/36 ,  G06K9/46 ,  G06K9/4609 ,  G06K9/4652

摘要： A fundus camera using infrared light sources, which included an imaging optical path and an optical path for focusing and positioning and two optical paths share a common set of retina objective lens, and a computer-assisted method for retinal vessel segmentation in general and diabetic retinopathy (DR) image segmentation in particular. The method is primarily based on Multiscale Production of the Matched Filter (MPMF) scheme, which together the fundus camera, is useful for non-invasive diabetic retinopathy detection and monitoring.

摘要翻译： 使用红外光源的眼底照相机，其包括成像光路和用于聚焦和定位的光路，以及两个光路共享一组共同的视网膜物镜，以及用于视网膜血管分割的计算机辅助方法和糖尿病性视网膜病变 （DR）图像分割。 该方法主要基于多尺度生产匹配滤波器（MPMF）方案，该方案一起使用眼底照相机，可用于非侵入性糖尿病视网膜病变检测和监测。

公开(公告)号：US20140301867A1

公开(公告)日：2014-10-09

申请号：US14124607

申请日：2012-06-06

申请人： Chun Li ,  Yunxing Liu

发明人： Chun Li ,  Yunxing Liu

IPC分类号： F04B45/02

CPC分类号： A61M25/10181 ,  A61M25/1018 ,  A61M25/10188 ,  F04B45/02

摘要： A balloon pressure pump comprising a cavity (1) having a distal end and a proximal end; a push rod (2) having a distal end and a proximal end, and provided with an external thread and inserted into the cavity; a handle (3) fixedly connected with the proximal end of the push rod (2); a locking member (4) having a distal end and a proximal end and arranged on the proximal end of the push rod (2) and used to lock same; the distal end of the locking member (4) is fixedly connected with the proximal end of the cavity (1). The handle (3) is internally provided with a sleeve (5) to accommodate the push rod (2); said sleeve (5) is fixedly connected with the proximal end of the locking member (4). The proximal end of the push rod (2) includes a spring (11) which is enclosed within the sleeve. The simple structure of the pump simplifies operations such as pressure application, pressure relief, negative pressure evacuation and the like, and is greatly convenient for a user.

摘要翻译： 一种球囊压力泵，包括具有远端和近端的空腔（1） 具有远端和近端的推杆（2），并且设置有外螺纹并插入所述空腔中; 与所述推杆（2）的近端固定连接的手柄（3）; 锁定构件（4），其具有远端和近端并且布置在推杆（2）的近端上并且用于将其锁定; 锁定构件（4）的远端与空腔（1）的近端固定连接。 手柄（3）内部设置有套筒（5）以容纳推杆（2）; 所述套筒（5）与所述锁定构件（4）的近端固定连接。 推杆（2）的近端包括封闭在套筒内的弹簧（11）。 泵的简单结构简化了压力施加，减压，负压抽空等操作，并且对用户非常方便。

公开(公告)号：US08546371B2

公开(公告)日：2013-10-01

申请号：US13188642

申请日：2011-07-22

申请人： Dapeng Zhou ,  Chun Li

发明人： Dapeng Zhou ,  Chun Li

IPC分类号： A01N43/00 ,  A61K31/33

CPC分类号： A61K39/39 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/57

摘要： A composition for stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells includes a glycolipid antigen and a nanoparticle conjugated with the glycolipid antigen. The glycolipid antigen and the nanoparticle are not antigenic in mouse and human being. The composition can further include covalent or non-covalent connection between the glycolipid antigen and the nanoparticle. The glycolipid antigen is alpha-galactosylceramide or an analog of that. The nanoparticle can be a polymer. A production method of the composition includes preparing a nanoparticle and a glycolipid antigen and loading the glycolipid antigen to the nanoparticle. The glycolipid antigen can be coated onto the surface of the nanoparticle or encapsulated within the nanoparticle. A method of stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells is also provided.

摘要翻译： 用于刺激NKT细胞以产生抗癌和抗病毒细胞因子而不引起NKT细胞的无反应性的组合物包括糖脂抗原和与糖脂抗原缀合的纳米颗粒。 糖脂抗原和纳米颗粒在小鼠和人中不是抗原性的。 组合物还可以包括糖脂抗原和纳米颗粒之间的共价或非共价连接。 糖脂抗原是α-半乳糖神经酰胺或其类似物。 纳米颗粒可以是聚合物。 组合物的制备方法包括制备纳米颗粒和糖脂抗原并将糖脂抗原加载到纳米颗粒中。 糖脂抗原可以涂覆在纳米颗粒的表面上或者包封在纳米颗粒内。 还提供了刺激NKT细胞以产生抗癌和抗病毒细胞因子而不引起NKT细胞的无反应性的方法。

公开(公告)号：US20120071472A1

公开(公告)日：2012-03-22

申请号：US13171102

申请日：2011-06-28

申请人： Kai Liu ,  Christopher B. Cooper ,  Haihong Huang ,  Chun Li ,  Binna Liu ,  Yang Liu ,  Zhenkun Ma ,  Jingbin Wang ,  Dali Yin ,  Dongfeng Zhang ,  Gang Zhang ,  Hao Zhang

发明人： Kai Liu ,  Christopher B. Cooper ,  Haihong Huang ,  Chun Li ,  Binna Liu ,  Yang Liu ,  Zhenkun Ma ,  Jingbin Wang ,  Dali Yin ,  Dongfeng Zhang ,  Gang Zhang ,  Hao Zhang

IPC分类号： A61K31/498 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  A61P31/06 ,  A61K31/5377 ,  C07D405/14 ,  C07D409/14 ,  A61P31/04 ,  C07D403/12 ,  C07D413/14

CPC分类号： C07D409/14 ,  A61K31/498 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D407/14 ,  C07D409/12

摘要： The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

摘要翻译： 本发明涉及具有杂芳香取代基，包括具有2-杂芳基 - 氨基取代基的那些，其制备方法及其用作治疗结核分枝杆菌和其它微生物感染的药物，其单独使用或与其它抗感染治疗组合 。

公开(公告)号：US08071125B2

公开(公告)日：2011-12-06

申请号：US12096545

申请日：2005-12-09

申请人： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

发明人： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

IPC分类号： A61F13/00

CPC分类号： A61K9/7061 ,  A61K31/138 ,  A61K31/724

摘要： This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.

摘要翻译： 本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物 作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。 动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。 结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。 此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化 该补丁仅含有硝酸异山梨酯或比索洛尔。

公开(公告)号：US20110071393A1

公开(公告)日：2011-03-24

申请号：US12563002

申请日：2009-09-18

申请人： Yunxing Liu ,  Chun Li

发明人： Yunxing Liu ,  Chun Li

IPC分类号： A61B6/00 ,  A61M5/315

CPC分类号： A61M5/31501 ,  A61B6/481 ,  A61B6/504 ,  A61M5/007 ,  A61M5/20 ,  A61M5/3129 ,  A61M5/3148 ,  A61M5/31505 ,  A61M5/31511 ,  A61M2005/3139 ,  A61M2005/31508

摘要： A locking syringe with an integrated bias member, for delivering medical fluids at high pressure, can include a housing, a shaft, a piston, a cap assembly, a bias member, and a locking member. A distal end of the housing can interface with a patient delivery apparatus. The housing includes an internal cavity into which a distal end of the shaft can be inserted. The piston can be connected to the distal end of the shaft and can include a peripheral sealing surface that can slidably engage the inside surface of the housing to form a movable seal. The cap assembly at the proximal end of the housing can engage the shaft. A base cap can secure the piston within the housing. The bias member can have a distal end coupled to the piston and a proximal end restrained, such as to help pressurize the internal cavity. The user-actuatable locking member can user-selectively engage and inhibit unwanted movement of the shaft.

摘要翻译： 具有用于在高压下输送医用流体的集成偏压构件的锁定注射器可以包括壳体，轴，活塞，帽组件，偏置构件和锁定构件。 壳体的远端可以与患者输送装置接合。 壳体包括内腔，轴的远端可以插入其中。 活塞可以连接到轴的远端并且可以包括周边密封表面，其可滑动地接合壳体的内表面以形成可移动的密封。 在壳体的近端处的帽组件可以接合轴。 底盖可以将活塞固定在壳体内。 偏置构件可以具有联接到活塞的远端和约束的近端，例如帮助加压内部空腔。 用户可致动的锁定构件可以用户选择性地接合并阻止轴的不期望的运动。