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    Marker detection method and apparatus to monitor drug compliance
    1.
    发明申请
    Marker detection method and apparatus to monitor drug compliance 审中-公开
    监测药物依从性的标记检测方法和仪器

    公开(公告)号：US20050233459A1

    公开(公告)日：2005-10-20

    申请号：US11097647

    申请日：2005-04-01

    申请人： Richard Melker ,  Donn Dennis ,  Laszlo Prokai

    发明人： Richard Melker ,  Donn Dennis ,  Laszlo Prokai

    IPC分类号： A61B5/00 ,  A61M11/00

    CPC分类号： G01N33/497 ,  A61B5/082 ,  A61B5/411 ,  A61B5/4833 ,  Y10T436/13

    摘要： The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient.

    摘要翻译： 本发明包括通过在药物摄取之后通过检测患者呼气时检测诸如气味的标记物来监测血液中的治疗药物浓度的系统和方法，其中这样的标记物直接从药物本身或与药物本身结合的添加剂 药物。 在嗅觉标记的情况下，本发明优选利用诸如被称为“人造”或“电子”鼻子或舌头的商业装置的电子传感器技术非侵入性地监测血液中的药物水平。 本发明还包括能够跟踪血液（偏远或邻近位置）中的药物浓度并提供关于患者中无效或有毒药物剂量的必要警报的报告系统。

    Novel application of biosensors for diagnosis and treatment of disease
    2.
    发明申请
    Novel application of biosensors for diagnosis and treatment of disease 审中-公开
    新型应用生物传感器诊断和治疗疾病

    公开(公告)号：US20060160134A1

    公开(公告)日：2006-07-20

    申请号：US11296757

    申请日：2005-12-07

    申请人： Richard Melker ,  Donn Dennis ,  Charles Martin ,  Jon Stewart

    发明人： Richard Melker ,  Donn Dennis ,  Charles Martin ,  Jon Stewart

    IPC分类号： G01N33/53

    CPC分类号： G01N33/531 ,  G01N33/53 ,  G01N33/542 ,  G01N33/58 ,  G01N33/582

    摘要： A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with signaling agents or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.

    摘要翻译： 一种用于检测体液中感兴趣的化合物的方法，包括呼出的呼吸和血液。 本发明使用模拟天然存在的细胞机制的生物传感器，包括RNA寡核苷酸链或“适体”，与信号传导剂或纳米技术组合，以提供用于诊断患者内的病症和/或疾病的有效和有效的方法。 本发明还提供了用于筛选可能存在于呼出气中的那些分析物/生物标志物的方法。

    NOVEL APPLICATION OF NANOTECHNOLOGY AND SENSOR TECHNOLOGIES FOR EX-VIVO DIAGNOSTICS
    3.
    发明申请
    NOVEL APPLICATION OF NANOTECHNOLOGY AND SENSOR TECHNOLOGIES FOR EX-VIVO DIAGNOSTICS 失效
    纳米技术与传感器技术在急诊诊断中的应用

    公开(公告)号：US20060040318A1

    公开(公告)日：2006-02-23

    申请号：US10678506

    申请日：2003-10-02

    申请人： Richard Melker ,  Ronald Hayes ,  Ka-Wang Wang ,  Donn Dennis

    发明人： Richard Melker ,  Ronald Hayes ,  Ka-Wang Wang ,  Donn Dennis

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54306 ,  B82Y5/00 ,  G01N33/54346 ,  G01N33/54373

    摘要： Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination with sensor technology to provide an efficient and accurate means for identifying the presence of a target analyte/biomarker in a sample of bodily fluid. In a preferred embodiment, the nanostructure-based assemblies of the present invention include detecting means such as RNA oligonucleotide chains or “aptamers” and releasable surrogate markers such as DMSO.

    摘要翻译： 用于体液样本的体外诊断分析的系统和方法，包括呼出的呼吸和血液。 本发明使用基于纳米结构的组件与传感器技术结合，以提供用于识别体液样品中目标分析物/生物标志物的存在的有效且准确的方法。 在优选的实施方案中，本发明的基于纳米结构的组合物包括检测手段，例如RNA寡核苷酸链或“适体”和可释放的替代标记如DMSO。

    System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring
    5.
    发明申请
    System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring 审中-公开
    用于实时诊断，治疗和治疗药物监测的系统和方法

    公开(公告)号：US20070258894A1

    公开(公告)日：2007-11-08

    申请号：US10588749

    申请日：2005-02-28

    申请人： Richard Melker ,  James Sackellares ,  Mark Gold ,  Donn Dennis

    发明人： Richard Melker ,  James Sackellares ,  Mark Gold ,  Donn Dennis

    IPC分类号： A61K9/51

    CPC分类号： A61B5/14546 ,  A61B5/0836 ,  A61B5/145 ,  A61B5/411 ,  A61B5/4833 ,  G01N33/497

    摘要： Systems and methods for diagnosing and/or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and/or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and/or monitoring disease treatment.

    摘要翻译： 用于诊断和/或治疗疾病以及监测疾病治疗的系统和方法。 为了诊断，本发明使用纳米颗粒基组件，其包含纳米颗粒; 替代标记 以及用于检测特定化学实体的手段。 在某些实施方案中，基于纳米颗粒的组件包括用于同时诊断和治疗疾病的有效载荷。 在另外的实施方案中，将治疗药物和治疗药物标记物施用于患者以监测疾病治疗。 使用传感器技术分析体液样品以检测替代物和/或治疗药物标记物的存在，以提供用于诊断疾病和/或监测疾病治疗的有效和准确的手段。

    Detection and measurement of hematological parameters characterizing cellular blood components
    7.
    发明申请
    Detection and measurement of hematological parameters characterizing cellular blood components 审中-公开
    检测和测量表征细胞血液成分的血液学参数

    公开(公告)号：US20060257883A1

    公开(公告)日：2006-11-16

    申请号：US11125937

    申请日：2005-05-10

    申请人： David Bjoraker ,  Richard Melker ,  Donn Dennis

    发明人： David Bjoraker ,  Richard Melker ,  Donn Dennis

    IPC分类号： C12Q1/68 ,  G01N33/92 ,  G01N33/00

    CPC分类号： G01N33/54373 ,  G01N33/54346 ,  G01N33/86 ,  Y02A50/58

    摘要： Systems and methods for the diagnostic analysis of blood samples. The present invention uses sensor technology useful in the analysis of headspace sample from blood to provide an efficient and accurate means for identifying the presence of a volatile marker associated with hematological diseases or conditions. In a preferred embodiment, the sensor technology of the present invention includes detecting means such as RNA oligonucleotide chains or aptamers.

    摘要翻译： 血液样本诊断分析的系统和方法。 本发明使用用于分析来自血液的顶空样品的传感器技术，以提供用于鉴定与血液疾病或病症相关的挥发性标记的存在的有效且准确的方法。 在优选实施方案中，本发明的传感器技术包括检测手段，如RNA寡核苷酸链或适体。

    Imaging scope
    8.
    发明申请
    Imaging scope 审中-公开
    成像范围

    公开(公告)号：US20050182297A1

    公开(公告)日：2005-08-18

    申请号：US10982154

    申请日：2004-11-05

    申请人： Dietrich Gravenstein ,  Samsun Lampotang ,  Richard Melker

    发明人： Dietrich Gravenstein ,  Samsun Lampotang ,  Richard Melker

    IPC分类号： A61B1/04 ,  A61B1/267 ,  A61M16/04 ,  A61B1/00 ,  A62B9/06

    CPC分类号： A61B1/2676 ,  A61B1/00167 ,  A61B1/0017 ,  A61B1/042 ,  A61B1/07 ,  A61B5/064

    摘要： Disclosed is an intubation imaging stylet for intubating a patient by use in a tube/imaging stylet combination, said imaging stylet comprising: a malleable stylet having a longitudinal axis and a proximal end and a distal end; a flexible image guide having a longitudinal axis and a proximal end and a distal end, said image guide being connected to said stylet such that a portion of said image guide runs parallel to a portion of said stylet along the longitudinal axis of said stylet and such that the distal end of said image guide is co-extensive with the distal end of said stylet; and at least one flexible illumination fiber having a proximal end and a distal end, said illumination fiber being connected to said stylet such that a portion of said illumination fiber runs parallel to a portion of said stylet along the longitudinal axis of said stylet and such that the distal end of said illumination fiber is co-extensive with the distal end of said stylet; such that in use, said imaging stylet is disposed within a tube for intubating a patient thereby forming an imaging stylet/tube combination which in use is held by gripping the tube in a pen-like fashion. The imaging stylet/tube combination is thus in use held in one hand, freeing the other hand of the user for other tasks if necessary, as well as permitting intubation in the conventional manner. To facilitate this, the center of gravity of the imaging stylet/tube combination is located in essentially the same location along the tube as with a conventional stylet/tube combination.

    摘要翻译： 公开了一种插管成像探针，用于通过使用管/成像探针组合来插入患者，所述成像探针包括：具有纵向轴线和近端和远端的可延展的探针; 具有纵向轴线和近端和远端的柔性图像引导件，所述图像引导件连接到所述探针，使得所述图像引导件的一部分沿着所述探针的纵向轴线平行于所述探针的一部分平行， 所述图像引导件的远端与所述探针的远端共同延伸; 以及至少一个具有近端和远端的柔性照明光纤，所述照明光纤连接到所述探针，使得所述照明光纤的一部分沿着所述探针的纵向轴线平行于所述探针的一部分延伸，并且使得 所述照明光纤的远端与所述探针的远端共同延伸; 使得在使用中，所述成像探针设置在用于插管患者的管内，从而形成成像探针/管组合，其在使用中通过以笔状夹持管来保持。 因此，一方面使用成像探针/管组合，如果必要，释放用户的另一只手用于其他任务，并且以常规方式允许插管。 为了促进这一点，成像探针/管组合的重心位于沿着管的基本相同的位置，与传统的探针/管组合一样。

    Tracheotomy surgical device
    9.
    发明申请
    Tracheotomy surgical device 审中-公开
    气管切开手术器械

    公开(公告)号：US20050076915A1

    公开(公告)日：2005-04-14

    申请号：US11002410

    申请日：2004-12-02

    申请人： Jeremy Melker ,  Richard Melker

    发明人： Jeremy Melker ,  Richard Melker

    IPC分类号： A61M16/04 ,  A61M16/00

    CPC分类号： A61M16/0472

    摘要： Disclosed herein is a novel surgical instrument, and method of using same, designed for performing tracheotomy. According to specific embodiments, the subject surgical instrument comprises a novel foot plate that is anatomically curved to follow the contours of the inner wall of the trachea.

    摘要翻译： 本文公开了一种新颖的手术器械及其使用方法，设计用于执行气管切开术。 根据具体实施例，所述主体外科器械包括新颖的脚踏板，其解剖学上弯曲以跟随气管内壁的轮廓。

    SYSTEMS AND METHODS FOR PHYSIOLOGICAL MONITORING USING MULTIPLE SIGNAL PROCESSING DEVICES
    10.
    发明申请
    SYSTEMS AND METHODS FOR PHYSIOLOGICAL MONITORING USING MULTIPLE SIGNAL PROCESSING DEVICES 有权
    使用多个信号处理设备进行生理监测的系统和方法

    公开(公告)号：US20150073233A1

    公开(公告)日：2015-03-12

    申请号：US14310569

    申请日：2014-06-20

    申请人： David Rich ,  Andrew Kersey ,  Sean Cohen ,  Richard Melker

    发明人： David Rich ,  Andrew Kersey ,  Sean Cohen ,  Richard Melker

    IPC分类号： A61B5/0205 ,  A61B5/00

    摘要： Provided according to embodiments of the invention are systems for monitoring a physiological state of an individual that include a PPG sensor, which optionally includes an auxiliary physiological sensor integrated with or connected thereto; a first signal processing device in electronic communication with the PPG sensor, whereby the PPG sensor transmits PPG signals to the first signal processing device; and a second signal processing device that detects at least a portion of the signals transmitted by the PPG sensor to the first signal processing device, at least a portion of signals transmitted by the auxiliary physiological sensor, or both. Related methods are also provided herein.

    摘要翻译： 根据本发明的实施例提供的是用于监视个体的生理状态的系统，其包括PPG传感器，其可选地包括与其集成或连接的辅助生理传感器; 与PPG传感器电子通信的第一信号处理装置，由此PPG传感器将PPG信号传输到第一信号处理装置; 以及第二信号处理装置，其将由PPG传感器发送的信号的至少一部分检测到第一信号处理装置，由辅助生理传感器发送的信号的至少一部分或两者。 本文还提供了相关方法。