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110 条记录 (耗时 0.032 秒)

    METHOD FOR PRODUCING BETA-ALANYL-AMINO ACID OR DERIVATIVE THEREOF
    1.
    发明申请
    METHOD FOR PRODUCING BETA-ALANYL-AMINO ACID OR DERIVATIVE THEREOF 审中-公开
    生产β-氨基酸或其衍生物的方法

    公开(公告)号：US20110081678A1

    公开(公告)日：2011-04-07

    申请号：US12943509

    申请日：2010-11-10

    申请人： Rie Takeshita ,  Yasuaki Takakura ,  Shunichi Suzuki ,  Kenzo Yokozeki

    发明人： Rie Takeshita ,  Yasuaki Takakura ,  Shunichi Suzuki ,  Kenzo Yokozeki

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N9/00 ,  C12N5/10

    CPC分类号： C12P21/02 ,  C07K5/0202 ,  C12N9/48

    摘要： The present invention provides a method for efficiently producing a β-alanyl-amino acid (e.g., carnosine) or derivative thereof. Specifically, it provides a method for producing a β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof, by reacting a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof in the presence of an enzyme or an enzyme-containing product that has an ability to form the β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof from the β-alanyl ester or the β-alanyl amide and the amino acid (e.g., histidine) or derivative thereof. The present invention also provides a protein which is able to catalyze production of a β-alanyl-amino acid or derivative thereof from a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof, and a polynucleotide encoding said protein.

    摘要翻译： 本发明提供了一种有效生产β-丙氨酰 - 氨基酸（如肌肽）或其衍生物的方法。 具体地说，本发明提供了一种通过使β-丙氨酰基酯或一种 - 丙氨酰基酰胺与氨基酸或氨基酸反应生产β-丙氨酰 - 氨基酸（例如， - 丙氨酰 - 组氨酸）或其衍生物的方法 其衍生物在酶或含酶产物的存在下具有从丙氨酰酯形成β-淀粉氨基酸（例如，β-丙氨酰 - 组氨酸）或其衍生物的能力，或 丙氨酰酰胺和氨基酸（如组氨酸）或其衍生物。 本发明还提供一种蛋白质，其能够催化β-氨基丙氨酰 - 氨基酸或其衍生物从β-丙氨酰酯或其 - 氨基酸或其衍生物及其衍生物的产生，以及多核苷酸 编码所述蛋白质。

    Mutant protein having the peptide-synthesizing activity
    4.
    发明申请
    Mutant protein having the peptide-synthesizing activity 审中-公开
    具有肽合成活性的突变蛋白

    公开(公告)号：US20060188976A1

    公开(公告)日：2006-08-24

    申请号：US11311467

    申请日：2005-12-20

    申请人： Rie Takeshita ,  Isao Abe ,  Masakazu Sugiyama ,  Kenzo Yokozeki ,  Seiichi Hara ,  Sonoko Suzuki ,  Shunichi Suzuki ,  Kunihiko Watanabe

    发明人： Rie Takeshita ,  Isao Abe ,  Masakazu Sugiyama ,  Kenzo Yokozeki ,  Seiichi Hara ,  Sonoko Suzuki ,  Shunichi Suzuki ,  Kunihiko Watanabe

    IPC分类号： C12N9/48 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C12N15/74

    CPC分类号： C07K14/00 ,  C07K14/195 ,  C12N9/93

    摘要： The present invention is to provide an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. A peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II): (I) The mutant protein having the amino acid sequence containing one or more mutations of the above mutations 1 to 38 in the amino acid sequence described in SEQ ID NO:2; and (II) The mutant protein having the amino acid sequence containing one or more mutations selected from the group consisting of substitution, deletion, insertion, addition and inversion at positions other than one or more mutation positions of the above mutation 1 to 38 in the mutant protein described in the above (I), and having a peptide-synthesizing activity.

    摘要翻译： 本发明提供优异的肽合成蛋白质和有效生产肽的方法。 在下列（I）和（II）所示的至少一种蛋白质的存在下，使胺组分和羧基组分反应合成肽：（I）具有含有一个或多个突变的氨基酸序列的突变蛋白 在SEQ ID NO：2中描述的氨基酸序列中的上述突变1至38; 和（II）具有在上述变异株1〜38中的一个以上突变位置以外的位置上具有选自取代，缺失，插入，添加和倒位的一个或多个突变的氨基酸序列的突变蛋白质 上述（I）所述的突变型蛋白质，具有肽合成活性。

    METHOD FOR PRODUCING SERINE DERIVATIVE AND PROTEIN USED FOR THE SAME
    7.
    发明申请
    METHOD FOR PRODUCING SERINE DERIVATIVE AND PROTEIN USED FOR THE SAME 有权
    生产用于其的丝氨酸衍生物和蛋白质的方法

    公开(公告)号：US20100317068A1

    公开(公告)日：2010-12-16

    申请号：US12836984

    申请日：2010-07-15

    申请人： Shinji Kuroda ,  Masakazu Sugiyama ,  Kunihiko Watanabe ,  Shunichi Suzuki ,  Kenzo Yokozeki ,  Tatsuki Kashiwagi

    发明人： Shinji Kuroda ,  Masakazu Sugiyama ,  Kunihiko Watanabe ,  Shunichi Suzuki ,  Kenzo Yokozeki ,  Tatsuki Kashiwagi

    IPC分类号： C12P13/06 ,  C07H21/00 ,  C12N9/10 ,  C12N1/21

    CPC分类号： C12N9/1029 ,  C12P13/04

    摘要： The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.

    摘要翻译： 本发明描述了通过方便的技术产生丝氨酸衍生物和光学活性异构体的方法，以及在该方法中有用的酶等。 在具有酶活性的下列蛋白质（A）和/或（B）的存在下，α-氨基酸与醛反应形成丝氨酸衍生物：（A）包含SEQ ID NO：1的氨基酸序列的蛋白质 （B）包含SEQ ID NO：5的氨基酸序列但包括取代，缺失，插入和加入一个或多个氨基酸的蛋白质，并且能够催化该反应以形成丝氨酸衍生物 。

    Transporter protein
    8.
    发明授权
    Transporter protein 失效
    转运蛋白

    公开(公告)号：US07320794B2

    公开(公告)日：2008-01-22

    申请号：US11276614

    申请日：2006-03-08

    申请人： Shunichi Suzuki ,  Kenzo Yokozeki ,  Peter Henderson

    发明人： Shunichi Suzuki ,  Kenzo Yokozeki ,  Peter Henderson

    IPC分类号： A61K39/00 ,  A61K39/38 ,  C12P1/00 ,  C12P21/06 ,  C07K1/00 ,  C07H21/04

    CPC分类号： C07K14/195

    摘要： A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to uptake hydantoin compounds is obtained by introducing and expressing the novel gene, called mhp, using gene recombination techniques.

    摘要翻译： 描述了具有转运乙内酰脲化合物的活性的新型蛋白质，以及表达该转运蛋白的重组体。 从微型液化酵母菌株AJ3912开始，发现了一种能够转运乙内酰脲化合物的蛋白质的新基因。 通过使用基因重组技术引入和表达新的基因，称为mhp，获得具有优异吸收乙内酰脲化合物能力的重组体。

    Method for producing serine derivative and protein used for the same
    9.
    发明授权
    Method for producing serine derivative and protein used for the same 有权
    用于制备丝氨酸衍生物和蛋白质的方法

    公开(公告)号：US08372607B2

    公开(公告)日：2013-02-12

    申请号：US12836984

    申请日：2010-07-15

    申请人： Shinji Kuroda ,  Masakazu Sugiyama ,  Kunihiko Watanabe ,  Shunichi Suzuki ,  Kenzo Yokozeki ,  Tatsuki Kashiwagi

    发明人： Shinji Kuroda ,  Masakazu Sugiyama ,  Kunihiko Watanabe ,  Shunichi Suzuki ,  Kenzo Yokozeki ,  Tatsuki Kashiwagi

    IPC分类号： C12P13/06 ,  C07H21/00 ,  C12N1/21

    CPC分类号： C12N9/1029 ,  C12P13/04

    摘要： The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.

    摘要翻译： 本发明描述了通过方便的技术产生丝氨酸衍生物和光学活性异构体的方法，以及在该方法中有用的酶等。 在具有酶活性的下列蛋白质（A）和/或（B）的存在下，α-氨基酸与醛反应形成丝氨酸衍生物：（A）包含SEQ ID NO：1的氨基酸序列的蛋白质 （B）包含SEQ ID NO：5的氨基酸序列但包括取代，缺失，插入和加入一个或多个氨基酸的蛋白质，并且能够催化该反应以形成丝氨酸衍生物 。