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    Mixed mode microfluidic systems
    7.
    发明申请
    Mixed mode microfluidic systems 审中-公开
    混合模式微流体系统

    公开(公告)号：US20070151852A1

    公开(公告)日：2007-07-05

    申请号：US11594705

    申请日：2006-11-07

    申请人： Ring-Ling Chien ,  J. Parce ,  Michael Spaid

    发明人： Ring-Ling Chien ,  J. Parce ,  Michael Spaid

    IPC分类号： C07K1/26 ,  G01N27/00

    CPC分类号： B01F13/0076 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  F04B19/006 ,  G01N27/44791 ,  H02N11/006

    摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.

    摘要翻译： 采用混合流体流动分布的方法和系统，通过通道网络优化材料的运动。 这些系统采用基于混合压力和电动的流动系统，用于通过互连的通道网络移动材料，同时保持各个通道段之间的互连。 特别地，本发明通常涉及通道网络，其中第一通道段中的流动由具有随后的抛物线流动分布的压力流驱动，而在互连的通道段中的流动由其动力流以及随之而来的塞流动分布主导。 本发明还提供了通道网络，其中通道段中的流体流动由压力和电场驱动，并且通过改变通道网络的各个通道段中施加的压力和电场来分离流体塞中包含的多个物质。

    Optical detector for echelle spectrometer
    8.
    发明授权
    Optical detector for echelle spectrometer 失效
    光电探测器

    公开(公告)号：US5596407A

    公开(公告)日：1997-01-21

    申请号：US477169

    申请日：1995-06-07

    申请人： Andrew T. Zander ,  Charles B. Cooper, III ,  Ring-Ling Chien

    发明人： Andrew T. Zander ,  Charles B. Cooper, III ,  Ring-Ling Chien

    IPC分类号： G01J3/18 ,  G01J3/28 ,  G01J3/36

    CPC分类号： G01J3/2803

    摘要： A solid-state detector for use in an atomic spectrometer comprises a plurality of arrays of sensing elements, or pixels, each of the arrays being positioned along and on the locations of spectral signals on a focal plane of an echelle grating spectrometer. The sensing elements are positioned along the many diffraction orders presented on a two-dimensional echelle grating focal plane so that at least one element is located at each and every resolution element regardless of global x-y coordinate positioning of the elements or with reference to each other. The result is a series of skewed lines of sensing elements, those lines being in the same shape as the series of diffraction order lines which comprise an echelle spectrum. The solid-state detector is particularly useful in an atomic spectrometer wherein an echelle grating is used to diffract incident radiation such that the various components of the radiation may be observed.

    摘要翻译： 用于原子光谱仪的固态检测器包括多个感测元件或像素阵列，每个阵列沿着光谱信号的位置定位在梯形光栅光谱仪的焦平面上。 感测元件沿着呈现在二维光栅焦平面上的许多衍射级定位，使得至少一个元件位于每个分辨率元素处，而不管元件的全局x-y坐标定位或彼此参考。 结果是传感元件的一系列偏斜线，那些线与包括梯形图的一系列衍射级线具有相同的形状。 固态检测器在原子光谱仪中特别有用，其中使用梯形光栅衍射入射辐射，使得可观察到辐射的各种成分。

    Method for determining diffusivity and molecular weight in a microfluidic device
    9.
    发明授权
    Method for determining diffusivity and molecular weight in a microfluidic device 有权
    用于确定微流体装置中的扩散系数和分子量的方法

    公开(公告)号：US07233865B2

    公开(公告)日：2007-06-19

    申请号：US11482342

    申请日：2006-07-06

    申请人： Ring-Ling Chien

    发明人： Ring-Ling Chien

    IPC分类号： G01N33/48 ,  G01N33/00 ,  G01N15/06 ,  G01N31/00 ,  G06F19/00

    CPC分类号： G01N30/00 ,  B01L3/5027 ,  G01N13/00 ,  G01N2013/003 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/2575

    摘要： The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.

    摘要翻译： 本发明涉及通过在微流体芯片上提供加成形微通道网络来确定样品溶质的分子量和扩散性的方法，所述微流体芯片具有在交叉点处相交的至少四个微通道; 将包含未知扩散系数的样品溶质和来自分离的微通道的空白流的样品流流过交叉点并流出到分离的微通道; 产生样品曲线，其测量在交叉点处从样品流扩散到空白流中的样品溶质的浓度，同时改变空白流或样品流之一的流速; 以及通过从具有与由样品溶质产生的类似条件下产生的已知分子量和/或扩散系数的至少两种溶质的相似曲线外推数据来确定样品溶质的扩散系数。

    Multi-reservoir pressure control system
    10.
    发明授权
    Multi-reservoir pressure control system 有权
    多层压力控制系统

    公开(公告)号：US07171983B2

    公开(公告)日：2007-02-06

    申请号：US10916270

    申请日：2004-08-11

    申请人： Ring-Ling Chien ,  J. Wallace Parce ,  Andrea W. Chow ,  Anne Kopf-Sill

    发明人： Ring-Ling Chien ,  J. Wallace Parce ,  Andrea W. Chow ,  Anne Kopf-Sill

    IPC分类号： F15C1/04 ,  F04B41/06

    CPC分类号： B01L9/527 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N11/08 ,  G01N27/44791 ,  G01N2035/1044 ,  G05D7/0694 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/86131

    摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.

    摘要翻译： 改进的微流体装置，系统和方法允许通过在多个储存器处施加，控制和改变压力来选择性地输送微流体网络的微流体通道内的流体。 将微流体网络建模为通过通道段连接在一起的一系列节点并且确定通道段的流动阻力特性可以允许计算通过在储存器处的给定压力构造导致的通道段的流体流动。 为了在特定通道或一系列通道内实现期望的流量，可以使用网络模型来识别储层压力。 粘度计或其他流量传感器可以测量通道内的流量特性，并且可以使用测量的流量特性来计算产生期望流量的压力。 多储层压力调节器和压力控制器系统可以可选地与电动或其它流体输送机构结合使用。