-
公开(公告)号：US08093177B2
公开(公告)日：2012-01-10
申请号：US12266130
申请日：2008-11-06
申请人： Robert J. Hamers , Bo Li , Elizabeth C. Landis , Ryan A. Franking
发明人： Robert J. Hamers , Bo Li , Elizabeth C. Landis , Ryan A. Franking
CPC分类号： C07F7/28 , C07F3/06 , C07F7/003 , Y02E10/542
摘要： Disclosed herein are methods for functionalizing metal oxides, including tin dioxide. The methods comprise contacting at least one linker precursor comprising a first functional group to a metal oxide and exposing the linker precursor to UV light. The first functional group covalently binds to the metal oxide via a UV light induced reaction. The linker precursor may be an alkene having a vinyl group or an alkyne having an ethynyl group. Other molecules, such as biomolecules and dye molecules, may be bound to the linker precursors. The functionalized metal oxides may be used alone or as coatings on a substrate and find use in a variety of devices, including biosensors and dye sensitized solar cells.
摘要翻译： 本文公开了用于官能化金属氧化物（包括二氧化锡）的方法。 所述方法包括使包含第一官能团的至少一个连接体前体与金属氧化物接触，并将连接体前体暴露于UV光。 第一官能团通过UV光诱导的反应与金属氧化物共价结合。 连接体前体可以是具有乙烯基或具有乙炔基的炔的烯烃。 其他分子，如生物分子和染料分子，可能与接头前体结合。 官能化的金属氧化物可以单独使用或作为基材上的涂层使用，并且可用于各种装置，包括生物传感器和染料敏化太阳能电池。
-
公开(公告)号：US20100108490A1
公开(公告)日：2010-05-06
申请号：US12266130
申请日：2008-11-06
申请人： Robert J. Hamers , Bo Li , Elizabeth C. Landis , Ryan A. Franking
发明人： Robert J. Hamers , Bo Li , Elizabeth C. Landis , Ryan A. Franking
IPC分类号： B01J19/12
CPC分类号： C07F7/28 , C07F3/06 , C07F7/003 , Y02E10/542
摘要： Disclosed herein are methods for functionalizing metal oxides, including tin dioxide. The methods comprise contacting at least one linker precursor comprising a first functional group to a metal oxide and exposing the linker precursor to UV light. The first functional group covalently binds to the metal oxide via a UV light induced reaction. The linker precursor may be an alkene having a vinyl group or an alkyne having an ethynyl group. Other molecules, such as biomolecules and dye molecules, may be bound to the linker precursors. The functionalized metal oxides may be used alone or as coatings on a substrate and find use in a variety of devices, including biosensors and dye sensitized solar cells.
摘要翻译： 本文公开了用于官能化金属氧化物（包括二氧化锡）的方法。 所述方法包括使包含第一官能团的至少一个连接体前体与金属氧化物接触，并将连接体前体暴露于UV光。 第一官能团通过UV光诱导的反应与金属氧化物共价结合。 连接体前体可以是具有乙烯基或具有乙炔基的炔的烯烃。 其他分子，如生物分子和染料分子，可能与接头前体结合。 官能化的金属氧化物可以单独使用或作为基材上的涂层使用，并且可用于各种装置，包括生物传感器和染料敏化太阳能电池。
-
3.发明授权公开(公告)号：US07183055B2
公开(公告)日：2007-02-27
申请号：US10694028
申请日：2003-10-27
CPC分类号： B82Y30/00 , B01J2219/00565 , B01J2219/00653 , B01J2219/00704 , B01J2219/00722 , B01L3/5027 , B82Y15/00 , C12Q1/6825 , C40B40/06 , C40B70/00 , G01N27/221 , C12Q2565/607
摘要： Radio-frequency (RF) excitation is used for direct detection of hybridization events at microelectrodes with surface-attached DNA oligomers. A homodyne reflectometer operates on a high frequency carrier to detect the presence of a low-frequency modulation signal. Without non-linearities in an interface, the modulation signal is not impressed upon the carrier signal. As such, the reflectometer can sensitively measure changes in dielectric properties without interference from other sources of capacitance/resistance unrelated to the reaction at the surface.
摘要翻译： 射频（RF）激发用于直接检测具有表面附着DNA寡聚物的微电极杂交事件。 零差反射计在高频载波上工作以检测低频调制信号的存在。 在接口没有非线性的情况下，调制信号不会对载波信号施加影响。 因此，反射计可以敏感地测量介电性能的变化，而不受来自与表面反应无关的其他电容/电阻源的干扰。
-
公开(公告)号：US06569979B1
公开(公告)日：2003-05-27
申请号：US09659442
申请日：2000-09-08
IPC分类号： C08G7700
CPC分类号： B82Y30/00 , B05D1/185 , B82Y10/00 , B82Y40/00 , H01L51/0093
摘要： Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
摘要翻译： 公开了未氧化的碳，硅和锗衬底上的化学修饰的表面。 紫外线辐射介导受保护的ω-改性的α-不饱和氨基烯烃（优选）与氢封端的碳，硅或锗表面的反应。 去除保护基产生氨基烷烃改性的硅表面。 这些氨基可以使用双功能交联剂与末端修饰的寡核苷酸偶联，从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。
-
公开(公告)号：US5908692A
公开(公告)日：1999-06-01
申请号：US786873
申请日：1997-01-23
IPC分类号： H01L21/312 , H01L51/40 , B32B15/04
CPC分类号： H01L21/312 , H01L51/0002 , Y10T428/261 , Y10T428/31678
摘要： Systems and methods for fabricating ordered anisotropic organic monolayers are described. An apparatus includes a substrate including a surface; and an ordered organic monolayer chemically bonded to the surface, the ordered organic monolayer including a plurality of cyclic organic molecules, each of the plurality of cyclic organic molecules being obtained from an unsaturated cyclic organic reactant that is chemically bonded to the surface through an addition reaction. The systems and methods provide advantages in that translational and rotational order from the substrate is extended into the monolayer.
摘要翻译： 描述了制备有序各向异性有机单层的系统和方法。 一种装置，包括：包括表面的基板; 化学键合到表面的有序有机单层，有序的有机单层包括多个环状有机分子，多个环状有机分子中的每一个均由不饱和的环状有机反应物获得，所述不饱和环状有机反应物通过加成反应与表面化学键合 。 这些系统和方法提供了优点，即从底物的平移和旋转顺序延伸到单层中。
-
公开(公告)号：US20090141376A1
公开(公告)日：2009-06-04
申请号：US12037332
申请日：2008-02-26
申请人： Lloyd M. Smith , Matthew R. Lockett , Michael R. Shortreed , Robert M. Corn , Stephen Weibel , Robert J. Hamers , Bin Sun
发明人： Lloyd M. Smith , Matthew R. Lockett , Michael R. Shortreed , Robert M. Corn , Stephen Weibel , Robert J. Hamers , Bin Sun
CPC分类号： G01N21/553 , G02B5/04
摘要： SPR-compatible substrates for high density microarray fabrication and analyses are provided. Novel carbon-on-metal thin film substrate architecture permits the integration of surface plasmon resonance detection with photolithographically fabricated biomolecule arrays for the analysis of biomolecular interactions. The utility of the technology is shown in the analysis of specific DNA-DNA, DNA-RNA and DNA-protein binding interactions. These new substrates may be used to determine the secondary structure of RNA molecules, to probe the sequence-specific binding kinetics and affinity of proteins and small molecules, and as substrates for small-molecule combinatorial chemistry platforms for drug discovery applications.
摘要翻译： 提供了用于高密度微阵列制造和分析的SPR兼容基板。 新的碳 - 金属薄膜基板架构允许将表面等离子体共振检测与光刻制造的生物分子阵列整合以用于生物分子相互作用的分析。 该技术的实用性在特异性DNA-DNA，DNA-RNA和DNA-蛋白结合相互作用的分析中显示。 这些新的底物可用于确定RNA分子的二级结构，以探测序列特异性结合动力学和蛋白质和小分子的亲和力，以及作为用于药物发现应用的小分子组合化学平台的底物。
-
公开(公告)号：US07466539B2
公开(公告)日：2008-12-16
申请号：US11240132
申请日：2005-09-30
IPC分类号： H01G9/00
摘要： Disclosed are supercapacitors having organosilicon electrolytes, high surface area/porous electrodes, and optionally organosilicon separators. Electrodes are formed from high surface area material (such as porous carbon nanotubes or carbon nanofibers), which has been impregnated with the electrolyte. These type devices appear particularly suitable for use in electric and hybrid electric vehicles.
摘要翻译： 公开了具有有机硅电解质，高表面积/多孔电极和任选的有机硅分离器的超级电容器。 电极由已经浸渍有电解质的高表面积材料（例如多孔碳纳米管或碳纳米纤维）形成。 这些类型的装置特别适用于电动和混合电动车辆。
-
公开(公告)号：US06689858B2
公开(公告)日：2004-02-10
申请号：US09770885
申请日：2001-01-26
申请人： Robert J. Hamers , Wei Cai , Lloyd M. Smith , Todd C. Strother
发明人： Robert J. Hamers , Wei Cai , Lloyd M. Smith , Todd C. Strother
IPC分类号： C08G7700
CPC分类号： B82Y10/00 , B05D1/185 , B82Y30/00 , B82Y40/00 , H01L51/0093
摘要： Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
摘要翻译： 公开了未氧化，溴或碘封端的碳，硅和锗衬底上的化学修饰的表面。 可见光介导受保护的ω-改性的α-不饱和氨基烯烃（优选）与溴或碘封端的碳，硅或锗表面的反应。 去除保护基产生氨基烷烃改性的硅表面。 这些氨基可以使用双功能交联剂与末端修饰的寡核苷酸偶联，从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。
-
公开(公告)号：US09651487B2
公开(公告)日：2017-05-16
申请号：US12037332
申请日：2008-02-26
申请人： Lloyd M. Smith , Matthew R. Lockett , Michael R. Shortreed , Robert M. Corn , Stephen Weibel , Robert J. Hamers , Bin Sun
发明人： Lloyd M. Smith , Matthew R. Lockett , Michael R. Shortreed , Robert M. Corn , Stephen Weibel , Robert J. Hamers , Bin Sun
IPC分类号： G02B5/04 , G01N21/552
CPC分类号： G01N21/553 , G02B5/04
摘要： SPR-compatible substrates for high density microarray fabrication and analyses are provided. Novel carbon-on-metal thin film substrate architecture permits the integration of surface plasmon resonance detection with photolithographically fabricated biomolecule arrays for the analysis of biomolecular interactions. The utility of the technology is shown in the analysis of specific DNA-DNA, DNA-RNA and DNA-protein binding interactions. These new substrates may be used to determine the secondary structure of RNA molecules, to probe the sequence-specific binding kinetics and affinity of proteins and small molecules, and as substrates for small-molecule combinatorial chemistry platforms for drug discovery applications.
-
10.发明申请High-Temperature Resistant Carbon Monofluoride Batteries Having Lithiated Anode 审中-公开具有锂化阳极的耐高温一氟化碳电池公开(公告)号：US20140093754A1
公开(公告)日：2014-04-03
申请号：US13644098
申请日：2012-10-03
申请人： Robert J. Hamers , Joseph C. Yeager
发明人： Robert J. Hamers , Joseph C. Yeager
CPC分类号： H01M4/386 , H01M4/5835 , H01M6/162 , H01M6/20
摘要： Disclosed are carbon monofluoride cathode batteries suitable for use at highly elevated temperatures. Rather than using a pure lithium anode, the anode has a base material selected from the group consisting of silicon, germanium and tin, where the base material is lithiated. This renders the anode more resistant to heat. Selected electrolytes are used which also contain lithium salts. Methods for using these batteries at high temperatures are also disclosed.
摘要翻译： 公开了适用于高度高温下使用的一氟化碳阴极电池。 阳极不是使用纯锂阳极，而是选自由硅，锗和锡组成的组的基材，其中基体材料被锂化。 这使得阳极更耐热。 使用还含有锂盐的选择的电解质。 还公开了在高温下使用这些电池的方法。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.039 秒)
