公开(公告)号：US08669050B2

公开(公告)日：2014-03-11

申请号：US10800322

申请日：2004-03-12

申请人： Robert James ,  Julianne Henry ,  Jan Kazenwadel ,  Nick Van Host Pellekaan ,  Anne MacPherson ,  Susan O'Connor

发明人： Robert James ,  Julianne Henry ,  Jan Kazenwadel ,  Nick Van Host Pellekaan ,  Anne MacPherson ,  Susan O'Connor

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates generally to novel nucleic acid molecules, the levels and/or patterns of expression of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm and to derivatives, homologues or analogues of said molecules. More particularly, the present invention is directed to novel nucleic acid molecules, the levels of expression of which are indicative of the onset and/or progression of a gastrointestinal tract neoplasm, such as an adenoma, and to derivatives, homologues or analogues of said molecules. The present invention is further directed to isolated proteins encoded thereby and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of prophylactic, therapeutic and/or diagnostic applications including, but not limited to, those relating to the diagnosis and/or treatment of colorectal neoplasms such as colorectal adenomas. In a related aspect, the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the level of expression of one or more nucleic acid molecule markers.

摘要翻译： 本发明一般涉及新的核酸分子，其表达的水平和/或模式指示肿瘤和所述分子的衍生物，同系物或类似物的起始和/或进展的倾向。 更具体地，本发明涉及新的核酸分子，其表达水平表示胃肠道肿瘤如腺瘤的发作和/或进展，以及所述分子的衍生物，同系物或类似物 。 本发明还涉及由其编码的分离的蛋白质及其衍生物，同系物，类似物，化学等价物和其模拟物。 本发明的分子可用于一系列预防，治疗和/或诊断应用，包括但不限于与结肠直肠肿瘤如结肠直肠腺瘤的诊断和/或治疗相关的那些应用。 在相关方面，本发明涉及通过筛选一种或多种核酸分子标记物的表达水平的调节来筛选受试者对于肿瘤发病和/或进展的易感性的方法。

公开(公告)号：US20050053967A1

公开(公告)日：2005-03-10

申请号：US10800322

申请日：2004-03-12

申请人： Robert James ,  Julianne Henry ,  Jan Kazenwadel ,  Nick Pellekaan ,  Anne MacPherson ,  Susan O'Connor

发明人： Robert James ,  Julianne Henry ,  Jan Kazenwadel ,  Nick Pellekaan ,  Anne MacPherson ,  Susan O'Connor

IPC分类号： C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates generally to novel nucleic acid molecules, the levels and/or patterns of expression of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm and to derivatives, homologues or analogues of said molecules. More particularly, the present invention is directed to novel nucleic acid molecules, the levels of expression of which are indicative of the onset and/or progression of a gastrointestinal tract neoplasm, such as an adenoma, and to derivatives, homologues or analogues of said molecules. The present invention is further directed to isolated proteins encoded thereby and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of prophylactic, therapeutic and/or diagnostic applications including, but not limited to, those relating to the diagnosis and/or treatment of colorectal neoplasms such as colorectal adenomas. In a related aspect, the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the level of expression of one or more nucleic acid molecule markers.

摘要翻译： 本发明一般涉及新的核酸分子，其表达的水平和/或模式指示肿瘤和所述分子的衍生物，同系物或类似物的起始和/或进展的倾向。 更具体地，本发明涉及新的核酸分子，其表达水平表示胃肠道肿瘤如腺瘤的发作和/或进展，以及所述分子的衍生物，同系物或类似物 。 本发明还涉及由其编码的分离的蛋白质及其衍生物，同系物，类似物，化学等价物和其模拟物。 本发明的分子可用于一系列预防，治疗和/或诊断应用，包括但不限于与结肠直肠肿瘤如结肠直肠腺瘤的诊断和/或治疗相关的那些应用。 在相关方面，本发明涉及通过筛选一种或多种核酸分子标记物的表达水平的调节来筛选受试者对于肿瘤发病和/或进展的易感性的方法。

公开(公告)号：US20050069910A1

公开(公告)日：2005-03-31

申请号：US10746339

申请日：2003-12-29

申请人： John Turner ,  Robert James ,  Stephen Fitter ,  Jan Kazenwadel ,  Danielle Horley

发明人： John Turner ,  Robert James ,  Stephen Fitter ,  Jan Kazenwadel ,  Danielle Horley

IPC分类号： C12N15/10 ,  C12Q1/68 ,  C12P19/34

CPC分类号： C12N15/1048

摘要： The present invention relates to a method for isolating a pool of nucleic acid ligands capable of binding to one or more target molecules in a complex mixture.

摘要翻译： 本发明涉及一种分离能够与复合物混合物中的一种或多种靶分子结合的核酸配体池的方法。

公开(公告)号：US11141014B2

公开(公告)日：2021-10-12

申请号：US16683548

申请日：2019-11-14

申请人： Robert James

发明人： Robert James

IPC分类号： A47G29/12 ,  A47G29/124 ,  A47G29/16

摘要： The present invention relates to a mailbox. The mailbox includes an extended downward sloping chute into and through which mail and packages destined for the mailbox's owner can be deposited. The length and orientation of the downward sloping chute makes it difficult if not impossible for the mailbox contents to be accessed and removed through the downward sloping chute. A locked door in the main portion of the box is provided to allow controlled and authorized access to the box's contents.

公开(公告)号：US20130285129A1

公开(公告)日：2013-10-31

申请号：US13976822

申请日：2011-12-19

申请人： Jacob Jensen ,  Tahir Ghani ,  Mark J. Liu ,  Harold Kennel ,  Robert James

发明人： Jacob Jensen ,  Tahir Ghani ,  Mark J. Liu ,  Harold Kennel ,  Robert James

IPC分类号： H01L29/66 ,  H01L29/78

CPC分类号： H01L29/7848 ,  H01L21/26506 ,  H01L21/268 ,  H01L21/324 ,  H01L29/0847 ,  H01L29/1037 ,  H01L29/165 ,  H01L29/41783 ,  H01L29/66628 ,  H01L29/66795 ,  H01L29/785 ,  H01L29/7851

摘要： A non-planar transistor including partially melted raised semiconductor source/drains disposed on opposite ends of a semiconductor fin with the gate stack disposed there between. The raised semiconductor source/drains comprise a super-activated dopant region above a melt depth and an activated dopant region below the melt depth. The super-activated dopant region has a higher activated dopant concentration than the activated dopant region and/or has an activated dopant concentration that is constant throughout the melt region. A fin is formed on a substrate and a semiconductor material or a semiconductor material stack is deposited on regions of the fin disposed on opposite sides of a channel region to form raised source/drains. A pulsed laser anneal is performed to melt only a portion of the deposited semiconductor material above a melt depth.

公开(公告)号：US20080005552A1

公开(公告)日：2008-01-03

申请号：US11761542

申请日：2007-06-12

申请人： John DiStefano ,  David Marks ,  John Klapper ,  John Yozallinas ,  Robert James

发明人： John DiStefano ,  David Marks ,  John Klapper ,  John Yozallinas ,  Robert James

IPC分类号： G06F15/177

CPC分类号： G05B19/0428 ,  G05B19/4186 ,  G05B2219/25428 ,  G05B2219/31104 ,  G05B2219/31121 ,  G05B2219/35285 ,  Y02P90/185

摘要： Systems and methods for safety data writes for process control networks are disclosed. The system may load changed parameters into a function block implemented by a process control server. The loaded changed parameters may be verified as being within safe limits and correctly entered. The verified changed parameters may be loaded into the field device controllers and the system restarted using the loaded changed parameters. The system may load parameters with an online system and use the loaded changed parameters during a warm restart.

摘要翻译： 公开了用于过程控制网络的安全数据写入的系统和方法。 系统可以将改变的参数加载到由过程控制服务器实现的功能块中。 加载的更改的参数可以被验证为在安全限制内并正确输入。 验证的更改的参数可能会加载到现场设备控制器中，并且使用加载的已更改参数重新启动系统。 系统可以使用在线系统加载参数，并在热启动期间使用加载的更改的参数。

公开(公告)号：US20070133731A1

公开(公告)日：2007-06-14

申请号：US11002680

申请日：2004-12-03

申请人： Russell Fawcett ,  Randy Gonzales ,  Russell Higgins ,  Robert James ,  Michael Kiernan ,  William Russell ,  Steven Shelton ,  David Smith ,  Russell Stachowski ,  Lukas Trosman

发明人： Russell Fawcett ,  Randy Gonzales ,  Russell Higgins ,  Robert James ,  Michael Kiernan ,  William Russell ,  Steven Shelton ,  David Smith ,  Russell Stachowski ,  Lukas Trosman

IPC分类号： G21G1/00

CPC分类号： G01S13/9303 ,  G21C1/303 ,  G21G1/02

摘要： In a method of producing isotopes in a light water power reactor, one or more targets within the reactor may be irradiated under a neutron flux to produce one or more isotopes. The targets may be assembled into one or more fuel bundles that are to be loaded in a core of the reactor at a given outage. Power operations in the reactor irradiate the fuel bundles so as to generate desired isotopes, such as one or more radioisotopes at a desired specific activity or stable isotopes at a desired concentration.

摘要翻译： 在轻水动力反应器中产生同位素的方法中，反应器内的一个或多个靶可以在中子通量下照射以产生一种或多种同位素。 目标可以组装成一个或多个燃料束，其将在给定的中断时被装载在反应器的核心中。 反应堆中的电力操作照射燃料束，以产生所需的同位素，例如具有所需比活度的一种或多种放射性同位素或所需浓度的稳定同位素。

公开(公告)号：US20070129588A1

公开(公告)日：2007-06-07

申请号：US11293934

申请日：2005-12-05

申请人： Tom Kalnes ,  Robert James ,  Daniel Wei ,  Bryan Glover

发明人： Tom Kalnes ,  Robert James ,  Daniel Wei ,  Bryan Glover

IPC分类号： C07C1/00 ,  B01J8/02 ,  B01J8/08

CPC分类号： C07C1/20 ,  C07C1/24 ,  C07C4/06 ,  C10G3/42 ,  C10G3/57 ,  C10G11/18 ,  C10G2400/20 ,  Y02P30/42 ,  Y02P30/48 ,  C07C11/02

摘要： Improved processing of an oxygenate-containing feedstock for increased production or yield of light olefins. Such processing involves oxygenate conversion to olefins and subsequent cracking of heavier olefins wherein at least a portion of the products from each of the reactors is elevated in pressure, using a common compressor, prior to being routed to a common product fractionation and recovery section. In one particular embodiment, the cracked product gas can be treated to remove acid gas therefrom. In another embodiment, the olefin cracking reactor is a moving bed reactor.

摘要翻译： 改进含氧化合物原料的加工，以提高轻质烯烃的生产或产率。 这种处理涉及含氧化合物转化为烯烃并随后开裂较重的烯烃，其中使用普通的压缩机将来自每个反应器的产物的至少一部分在压力下升高，然后被送至共同的产物分馏和回收段。 在一个具体实施方案中，可以处理裂化产物气体以从其中除去酸性气体。 在另一个实施方案中，烯烃裂解反应器是移动床反应器。

公开(公告)号：US20050215839A1

公开(公告)日：2005-09-29

申请号：US11137291

申请日：2005-05-25

申请人： Paula Bogdan ,  Robert James ,  Gregory Maher

发明人： Paula Bogdan ,  Robert James ,  Gregory Maher

IPC分类号： C07C5/22 ,  C07C5/27 ,  C07C6/12

CPC分类号： C07C6/126 ,  C07C15/073 ,  C07C15/08

摘要： The use of transalkylation catalysts to react heavy aromatic compounds of carbon number nine (and heavier carbon numbers) with benzene to form carbon number eight aromatics is disclosed. The catalyst system preserves ethyl-group species on the heavier aromatics that are otherwise de-ethylated over most gas-phase transalkylation catalysts to form undesired ethane gas with benzene or toluene. The catalyst system also promotes methyl-group species transalkylation at selected conditions. Thus, by using the transalkylation system, a greater yield of para-xylene or other carbon number eight aromatics may be achieved overall within an integrated aromatics complex.

公开(公告)号：US5592156A

公开(公告)日：1997-01-07

申请号：US539618

申请日：1995-10-05

申请人： Robert James

发明人： Robert James

IPC分类号： H04B13/02 ,  H04B11/00

CPC分类号： H04B13/02

摘要： A bi-directional underwater communication system provides a submerged operator the ability to communicate with a surface operator. Provides two transceivers both containing keypads and displays capable of transmitting and receiving alpha-numeric data. The underwater transceiver is connected to a floating antenna assembly via a small cable.

摘要翻译： 双向水下通信系统为浸没式操作员提供与地面操作者通信的能力。 提供两个收发器，其中包含能够发送和接收字母数字数据的键盘和显示器。 水下收发器通过小电缆连接到浮动天线组件。