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    ULTRASOFT ATOMIC FORCE MICROSCOPY DEVICE AND METHOD
    5.
    发明申请
    ULTRASOFT ATOMIC FORCE MICROSCOPY DEVICE AND METHOD 审中-公开
    超声原子力显微镜装置及方法

    公开(公告)号：US20100257643A1

    公开(公告)日：2010-10-07

    申请号：US12709118

    申请日：2010-02-19

    申请人： Ronald Reifenberger ,  Arvind Raman ,  Laura Butler Biedermann ,  Mehdi M. Yazdanpanah

    发明人： Ronald Reifenberger ,  Arvind Raman ,  Laura Butler Biedermann ,  Mehdi M. Yazdanpanah

    IPC分类号： G01Q60/24

    CPC分类号： G01Q60/38 ,  G01Q20/02

    摘要： A preferred embodiment of the invention provides an ultra-soft atomic force microscope device that has a nanoneedle cantilever that terminates in a smaller diameter nanofiber tip. Deflection of the nanoneedle cantilever is measured directly by a laser Doppler vibrometer. The invention simultaneously provides a very low mass nanoneedle cantilever arm with a very small diameter nanofiber tip, while being able to image the vibration and displacement. An AFM device of the invention simultaneously provides a ultra low mass and soft cantilever, the ability to accurately and directly measure vibration and deflection of the very small diameter nanoneedle cantilever with the laser Doppler vibrometer, and a sharp nanofiber tip that provides sub nanometer resolution.

    摘要翻译： 本发明的优选实施方案提供了一种超柔性原子力显微镜装置，其具有终止于较小直径的纳米纤维尖端的纳米针悬臂。 通过激光多普勒测振仪直接测量纳米针悬臂的偏转。 本发明同时提供了具有非常小直径的纳米纤维尖端的非常低质量的纳米针悬臂，同时能够对振动和位移进行成像。 本发明的AFM装置同时提供超低质量和软悬臂，使用激光多普勒振动计准确且直接地测量非常小直径的纳米针悬臂的振动和偏转的能力，以及提供亚纳米分辨率的锋利的纳米纤维尖端。

    Methods and Apparatuses of Using Metal Needle Arrays for Specimen Lift-Out and Circuit Edit
    6.
    发明申请
    Methods and Apparatuses of Using Metal Needle Arrays for Specimen Lift-Out and Circuit Edit 有权
    使用金属针阵列进行样品提取和电路编辑的方法和设备

    公开(公告)号：US20130199034A1

    公开(公告)日：2013-08-08

    申请号：US13366316

    申请日：2012-02-04

    申请人： Mehdi M. Yazdanpanah ,  Romaneh Jalilian

    发明人： Mehdi M. Yazdanpanah ,  Romaneh Jalilian

    IPC分类号： B23D81/00 ,  H05K3/10

    CPC分类号： H05K3/222 ,  G01N35/10 ,  H01J2237/208 ,  H01J2237/31732 ,  H01J2237/31745 ,  H01J2237/31749 ,  H01L21/76892 ,  H05K2201/0248 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49718 ,  Y10T29/49721 ,  Y10T29/49726 ,  Y10T29/4973

    摘要： Embodiments of the present invention provide method and apparatus of restoring probes attached to the manipulator in a control environment (e.g. vacuum chamber of an focus ion beam) without a need to open the vacuum chamber. Another embodiment of the present invention teaches construction and application of various shapes of nanoforks from a nanoneedles array inside a FIB vacuum chamber. In another embodiment, the present invention teaches edition and correction of completed and oxide-coated circuit boards by re-nano-wiring using nanoneedles of a nanoneedles array (as nanowire supply), contained in the same controlled space. In this embodiment, individual nanoneedles in a nanoneedle array are manipulated by a manipulator and placed in such a way to make electrical contact between the desired points.

    摘要翻译： 本发明的实施例提供了在控制环境（例如聚焦离子束的真空室）中恢复附接到操纵器的探针的方法和装置，而不需要打开真空室。 本发明的另一个实施方案教导了在FIB真空室内的纳米针阵列中构造和应用各种形状的纳摩耳。 在另一个实施例中，本发明通过使用包含在相同受控空间中的纳米针阵列（作为纳米线供应）的纳米针通过再纳米布线来教导完成的和氧化物涂覆的电路板的编辑和校正。 在该实施例中，纳米针阵列中的单个纳米针由操纵器操纵并且以这样的方式放置以在期望的点之间进行电接触。

    Apparatus and Methods for Detection of Tumor Cells in Blood
    7.
    发明申请
    Apparatus and Methods for Detection of Tumor Cells in Blood 有权
    血液中肿瘤细胞检测装置及方法

    公开(公告)号：US20120129192A1

    公开(公告)日：2012-05-24

    申请号：US13302650

    申请日：2011-11-22

    申请人： Mehdi M. Yazdanpanah ,  Romaneh Jalilian

    发明人： Mehdi M. Yazdanpanah ,  Romaneh Jalilian

    IPC分类号： G01N33/574 ,  H05K13/00 ,  C12M1/42

    CPC分类号： C12M23/16 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2400/086 ,  C12M41/36 ,  C12M47/04 ,  G01N33/5094 ,  Y10T29/49002

    摘要： In one embodiment, the present invention provides the description of an inexpensive and disposable handheld device for detecting Circulating tumor cells (CTC) in blood called a handheld CTC detector (HCTCD). The HCTCD is capable of detecting less than 1 CTC per milliliter. The HCTCD consists of a dense array of high aspect ratio freestanding metallic nanoneedles, functionalized with antibodies that integrated within a microfluidic device and selectively capture and count (using electrical signal detection) the CTCs. By selecting a right functionalization protocol for the nanoneedles array, the HCTCD can be used for selective capturing a variety of rare cells that are mixed in human fluids.

    摘要翻译： 在一个实施例中，本发明提供了用于检测称为手持式CTC检测器（HCTCD）的血液中的循环肿瘤细胞（CTC）的便宜且一次性的手持式装置的描述。 HCTCD能够检测每毫升少于1 CTC。 HCTCD由高度纵横比的独立金属纳米针组成，由集成在微流体装置内的抗体功能化，并选择性地捕获和计数（使用电信号检测）CTC。 通过选择纳米针阵列的正确功能化方案，HCTCD可用于选择性捕获在人体液体中混合的各种稀有细胞。

    Apparatus Made by Combining a Quartz Tuning Fork and a Microfluidic Channel for Low Dose Detection of Specific Specimens in a Liquid or Gas Media
    8.
    发明申请
    Apparatus Made by Combining a Quartz Tuning Fork and a Microfluidic Channel for Low Dose Detection of Specific Specimens in a Liquid or Gas Media 审中-公开
    通过组合石英调音叉和微流体通道进行液体或气体介质中特定样品低剂量检测的仪器

    公开(公告)号：US20160209367A1

    公开(公告)日：2016-07-21

    申请号：US14597403

    申请日：2015-01-15

    申请人： Mehdi M. Yazdanpanah

    发明人： Mehdi M. Yazdanpanah

    IPC分类号： G01N29/02

    CPC分类号： G01N29/022 ,  G01N29/032 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/02809 ,  G01N2291/0427

    摘要： Embodiments of present invention provide apparatus that can measure very low dose of a specific specimen (such as biomarkers, protein) in a liquid or gas media. The apparatus is made of a microfluidic channel in combination by a tuning fork. The tuning fork is located outside the micro channel, but there are fibers that are attached to the end of one of the fork prongs and The liquid or gas channel is to bring a small quantity of the liquid or gas of interest in contact with micro fibers that are connected from one side to the tuning fork and are located inside the channel from the other side. The fibers are coated with specific coating and are receptors for the molecule of interest.

    摘要翻译： 本发明的实施方案提供了可以在液体或气体介质中测量非常低剂量的特定样品（例如生物标记物，蛋白质）的装置。 该装置由通过音叉组合的微流体通道制成。 音叉位于微通道外部，但是有一些纤维连接到叉子之一的端部，液体或气体通道将使少量感兴趣的液体或气体与微纤维接触 它们从一侧连接到音叉，并从另一侧位于通道内。 纤维用特异性涂层包被，并且是感兴趣的分子的受体。

    Methods and Apparatuses for Specimen Lift-Out and Circuit Edit Using Needle Arrays
    9.
    发明申请
    Methods and Apparatuses for Specimen Lift-Out and Circuit Edit Using Needle Arrays 审中-公开
    使用针阵的样本提升和电路编辑的方法和设备

    公开(公告)号：US20140338076A1

    公开(公告)日：2014-11-13

    申请号：US14445392

    申请日：2014-07-29

    申请人： Mehdi M. Yazdanpanah

    发明人： Mehdi M. Yazdanpanah ,  Romaneh Jalilian ,  Brian Miller ,  David A. Mudd

    IPC分类号： G01Q80/00 ,  G01N1/02

    CPC分类号： G01N1/02 ,  B82Y30/00 ,  G01N1/32 ,  H01J37/00 ,  H01J2237/208 ,  H01J2237/31732 ,  H01J2237/31745 ,  H01J2237/31749 ,  H01L21/76838 ,  H05K3/222 ,  H05K2201/0248

    摘要： Embodiments of the present invention provide apparatus of restoring probes attached to the manipulator in a control environment (e.g. vacuum chamber of an focus ion beam) without a need to open the vacuum chamber. Another embodiment of the present invention teaches construction and application of various shapes of nanoforks from a nanoneedles array inside a FIB vacuum chamber. In another embodiment, the present invention teaches edition and correction of completed and oxide-coated circuit boards by re-nano-wiring using nanoneedles of a nanoneedles array (as nanowire supply), contained in the same controlled space. In this embodiment, individual nanoneedles in a nanoneedle array are manipulated by a manipulator and placed in such a way to make electrical contact between the desired points.

    摘要翻译： 本发明的实施例提供了在控制环境（例如聚焦离子束的真空室）中恢复附接到操纵器的探针的装置，而不需要打开真空室。 本发明的另一个实施方案教导了在FIB真空室内的纳米针阵列中构造和应用各种形状的纳摩耳。 在另一个实施例中，本发明通过使用包含在相同受控空间中的纳米针阵列（作为纳米线供应）的纳米针通过再纳米布线来教导完成的和氧化物涂覆的电路板的编辑和校正。 在该实施例中，纳米针阵列中的单个纳米针由操纵器操纵并且以这样的方式放置以在期望的点之间进行电接触。