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公开(公告)号:US20090092659A1
公开(公告)日:2009-04-09
申请号:US12130405
申请日:2008-05-30
申请人: Roderic M.K. Dale , Steven L. Gatton , Amy Arrow
发明人: Roderic M.K. Dale , Steven L. Gatton , Amy Arrow
CPC分类号: A01N57/16 , A61B17/06166 , A61B2017/00893 , A61K8/606 , A61K31/70 , A61L15/46 , A61L17/005 , A61L17/04 , A61L17/105 , A61L24/0015 , A61L24/106 , A61L27/54 , A61L27/60 , A61L2300/258 , A61L2300/404 , A61Q19/00
摘要: The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.
摘要翻译: 本发明提供了用于管理局部损伤感染的装置和组合物,每个装置和组合物在其表面上含有质子化/酸化的核酸或整合到装置中。 这些修饰的核酸在不考虑细菌类的情况下作为杀菌剂和/或抑菌剂是有效的,因此当诊断困难时或当存在多种感染性生物时特别有用。 本发明的核酸的抗生素活性不依赖于核酸的特定序列或核酸分子的长度。 本发明中使用的核酸被质子化/酸化,当溶解在低于pH7至约1,更优选小于pH 4.5至约1,甚至更优选小于pH 2至约1的水中时产生pH。
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2.
公开(公告)号:US20080234214A1
公开(公告)日:2008-09-25
申请号:US11673508
申请日:2007-02-09
申请人: Roderic M.K. Dale , Amy Arrow , Terry Thompson
发明人: Roderic M.K. Dale , Amy Arrow , Terry Thompson
IPC分类号: A61K31/7052 , A61P25/16 , A61P25/28
CPC分类号: C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译: 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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3.
公开(公告)号:US20080167257A1
公开(公告)日:2008-07-10
申请号:US11673509
申请日:2007-02-09
申请人: Roderic M.K. Dale , Amy Arrow , Terry Thompson
发明人: Roderic M.K. Dale , Amy Arrow , Terry Thompson
CPC分类号: C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译: 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号:US20070166801A1
公开(公告)日:2007-07-19
申请号:US11458378
申请日:2006-07-18
申请人: Roderic M.K. Dale , Lun-Quan Sun
发明人: Roderic M.K. Dale , Lun-Quan Sun
CPC分类号: C12N15/1131 , A61K38/00 , A61K39/145 , C07K14/005 , C12N2310/11 , C12N2310/321 , C12N2320/32 , C12Q1/701
摘要: The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment and prevention of influenza.
摘要翻译: 本发明提供了靶向流感基因的寡核苷酸组合物和涉及流感感染的宿主动物基因。 在一些实施方案中,寡核苷酸被修饰。 在一些实施方案中,组合物含有一种或多于一种的寡核苷酸。 本发明还提供了使用本发明组合物治疗和预防流感的方法和试剂盒。
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公开(公告)号:US20080220072A1
公开(公告)日:2008-09-11
申请号:US12027863
申请日:2008-02-07
CPC分类号: A61K9/5138 , A61K9/0019 , A61K9/5094 , A61K39/0011 , A61K47/62 , A61K47/645 , A61K47/6935 , A61K48/0008 , A61K48/0041 , A61K49/0065 , A61K49/0067 , A61K2039/55555 , A61L31/10 , A61L31/16 , B82Y5/00 , C12N15/111 , C12N15/87 , C12N2320/32
摘要: Certain aspects of the invention relate to the use of small particles in biological systems, including the delivery of biologically active agents to cells or tissues using nanoparticles of less than about 200 nm in approximate diameter. Embodiments include collection of particles having a bioactive component, a surfactant molecule, a biocompatible polymer, and a cell recognition component, wherein the cell recognition component has a binding affinity for a cell recognition target. Compositions and methods of use are also set forth, including the use of antisense directed against Protein Kinase CK2, CK2alpha, CK2 alpha′, and CK2 beta.
摘要翻译: 本发明的某些方面涉及在生物系统中使用小颗粒,包括使用近似直径小于约200nm的纳米颗粒将生物活性剂递送至细胞或组织。 实施方案包括收集具有生物活性成分的颗粒,表面活性剂分子,生物相容性聚合物和细胞识别组分,其中细胞识别组分对细胞识别目标具有结合亲和性。 还阐述了组合物和使用方法,包括使用针对蛋白激酶CK2,CK2alpha,CK2α'和CK2β的反义。
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公开(公告)号:US20080161257A1
公开(公告)日:2008-07-03
申请号:US11673486
申请日:2007-02-09
申请人: Roderic M.K. Dale , Amy Arrow , Terry Thompson
发明人: Roderic M.K. Dale , Amy Arrow , Terry Thompson
IPC分类号: A61K31/7088 , A61P3/00 , A61P19/00 , A61P25/00 , A61P17/00
CPC分类号: C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
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公开(公告)号:US20110135713A1
公开(公告)日:2011-06-09
申请号:US12985786
申请日:2011-01-06
申请人: Roderic M.K. Dale
发明人: Roderic M.K. Dale
IPC分类号: A61K9/127 , A61K31/7072 , A61K31/7028 , C07H19/10 , C07H11/04 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/16 , A61P31/20 , A61P31/14 , A61P31/22 , B82Y5/00
CPC分类号: A61K9/0014 , A61K9/1271 , A61K31/7072 , A61K31/7076 , C07H11/04 , C07H19/10 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: The present invention provides protonated compounds having antiviral and antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi. The invention also provides antiviral compositions comprising compounds of the invention. Viruses that may be treated by compositions of the invention include, but are not limited to, HIV, HSV, CMV, HBV, HCV and influenza virus.
摘要翻译: 本发明提供具有抗病毒和抗微生物活性的质子化化合物。 本发明还提供包含本发明的质子化化合物的抗微生物组合物。 本发明的质子化化合物为细菌和机会真菌的抗性菌株提供有效的抗微生物活性。 本发明还提供包含本发明化合物的抗病毒组合物。 可以通过本发明的组合物治疗的病毒包括但不限于HIV,HSV,CMV,HBV,HCV和流感病毒。
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公开(公告)号:US5849902A
公开(公告)日:1998-12-15
申请号:US754580
申请日:1996-11-21
申请人: Amy Arrow , Roderic M.K. Dale , Tod Mitchell Woolf
发明人: Amy Arrow , Roderic M.K. Dale , Tod Mitchell Woolf
IPC分类号: C12N15/09 , A61K31/7125 , A61K48/00 , C07H21/00 , C12N15/113 , C02Q1/68 , C07H21/04
CPC分类号: C12N15/113 , C12N2310/311 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/346
摘要: This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
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公开(公告)号:US20080119426A1
公开(公告)日:2008-05-22
申请号:US11479112
申请日:2006-06-30
申请人: Roderic M.K. Dale
发明人: Roderic M.K. Dale
IPC分类号: A61K48/00
CPC分类号: C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2310/3521
摘要: The invention provides compositions of oligonucleotides targeted at genes involved in muscle wasting and/or muscle growth. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment of muscle wasting conditions and/or the promotion of muscle growth.
摘要翻译: 本发明提供了靶向涉及肌肉消耗和/或肌肉生长的基因的寡核苷酸的组合物。 在一些实施方案中,寡核苷酸被修饰。 在一些实施方案中,组合物含有一种或多于一种的寡核苷酸。 本发明还提供了使用本发明组合物治疗肌肉消瘦状况和/或促进肌肉生长的方法和试剂盒。
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