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1.发明公开公开(公告)号：US20240216581A1
公开(公告)日：2024-07-04
申请号：US17911188
申请日：2021-09-17
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Xu HAN , Hanlian LIU , Peng YAO , Hongtao ZHU , Bin ZOU , Jun WANG
CPC classification number: A61L27/52 , A61L27/20 , A61L27/222 , B33Y10/00 , B33Y80/00 , C08J3/075 , C08J2305/04 , C08J2401/28 , C08J2405/00 , C08J2405/08
Abstract: A photocurable composite hydrogel matrix precursor, a preparation method thereof and a scaffold with same. The photocurable composite hydrogel matrix precursor includes gelatin methacrylate, sodium alginate, sodium carboxymethyl cellulose and chondroitin sulfate, where the mass ratio of a photoinitiator to the gelatin methacrylate to the sodium alginate to the sodium carboxymethyl cellulose to the chondroitin sulfate is (0.2-0.3):(8-10):(1-3):(0.6-0.8):(0.05-0.07). By adoption of the precursor, a cell-loaded printing hydrogel scaffold can be obtained through an extrusion-based 3D bio-printing technology, and the scaffold is controllable in form, good in moldability, high in precision, and has good stability; the biocompatibility and bioactivity are high, so that a good growing environment can be provided for fibroblasts; and the preparation process is simple and can be completed within a short time, moreover, the porosity and mechanical performance of the 3D printing hydrogel scaffold can be adjusted by adjusting the raw material ratio.
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2.发明公开公开(公告)号：US20230232721A1
公开(公告)日：2023-07-20
申请号：US17893563
申请日：2022-08-23
Applicant: YANSHAN UNIVERSITY , SHANDONG UNIVERSITY
Inventor： Chuanzhen HUANG , Kai MENG , Zhenyu SHI , Zhen WANG , Longhua XU , Dun LIU , Shuiquan HUANG , Xiaolan BAI
IPC: H01L41/18 , H01L41/083 , H01L41/273 , H01L41/37 , B23B27/14 , C04B35/10 , C04B35/468 , C04B35/491 , C04B35/626 , C04B35/645 , C22C32/00 , C22C30/00 , C22C29/12
CPC classification number: H01L41/183 , H01L41/083 , H01L41/273 , H01L41/37 , B23B27/148 , C04B35/10 , C04B35/4684 , C04B35/491 , C04B35/6261 , C04B35/645 , C22C32/0005 , C22C30/00 , C22C29/12 , C04B2235/3217 , C04B2235/3206 , C04B2235/3236 , C04B2235/3249 , C04B2235/3843 , C04B2235/3826 , C04B2235/405 , C04B2235/6581
Abstract: A ceramic tool material, in particular with piezoelectric effect and a preparation method thereof, and a cutting tool. The ceramic tool material includes the following raw materials by weight: 30-70 parts of matrix material, 30-70 parts of piezoelectric material, 5-10 parts of binder, and 10-20 parts of reinforcing phase and can be made into cutting tools. The cutting tool has a piezoelectric effect and excellent mechanical properties and can convert the cutting force signal into the charge signal during machining. By collecting charge signals, a cutting force can be measured and ceramic cutting tool condition can be monitored. Cutting force measurement function and high mechanical properties are integrated. A ceramic tool material with piezoelectric effect can measure the cutting force on the premise by meeting the cutting performance requirements.
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3.发明公开公开(公告)号：US20240302352A1
公开(公告)日：2024-09-12
申请号：US18182091
申请日：2023-03-10
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Zhuang CHEN , Hanlian LIU , Peng YAO , Dun LIU , Hongtao ZHU , Bin ZOU , Zhen WANG , Jun WANG , Longhua XU , Shuiquan HUANG , Meina QU , Zhengkai XU , Minting WANG , Yabin GUAN
IPC: G01N33/50 , B33Y70/00 , B33Y80/00 , C12N5/079 , C12N5/0793 , C12N5/0797
CPC classification number: G01N33/5082 , B33Y70/00 , B33Y80/00 , C12N5/0618 , C12N5/0619 , C12N5/0623 , C12N2501/13 , C12N2513/00 , C12N2533/54 , C12N2533/74
Abstract: A method of rapid constructing human cerebral cortical organoids by 3D bioprinting and an application including preparing microfluidic chips, preparation of hydrogel of human cerebral cortical organoids, and printing of human cerebral cortical organoids. The microfluidic chip comprises a mixed-flow channel layer, liquid pool layer, microporous array layer, human cerebral cortical organoid culture layer, and culture medium recovery layer; the human cerebral cortical organoid hydrogel has gelatin, alginate, and hyaluronic acid; printing directly human cerebral cortical organoids in microfluidic chips by FRESH printing method, obtaining human cerebral cortical organoid chips after packaging. The application directly constructs large-scale human cerebral cortex-like with three layers of mutually connected structures in situ in organ chip through 3D bioprinting, simulates cerebrospinal fluid circulation through perfusion culture.
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公开(公告)号：US20240131746A1
公开(公告)日：2024-04-25
申请号：US18168798
申请日：2023-02-14
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Yunpeng Feng , Hanlian Liu , Zhenyu Shi , Peng Yao , Dun Liu , Bin Zou , Hongtao Zhu , Zhen Wang , Jun Wang , Longhua Xu , Shuiquan Huang , Meina Qu , Zhengkai Xu , Minting Wang , Yabin Guan
IPC: B28B3/02 , C04B35/117 , C04B35/626 , C04B35/63 , C04B35/645
CPC classification number: B28B3/021 , C04B35/117 , C04B35/6261 , C04B35/6264 , C04B35/62655 , C04B35/6303 , C04B35/645 , C04B2235/3206 , C04B2235/3217 , C04B2235/3225 , C04B2235/3843 , C04B2235/3847 , C04B2235/404 , C04B2235/405 , C04B2235/604 , C04B2235/606 , C04B2235/75
Abstract: A method for preparing a shell-bionic ceramic tool and a shell-bionic ceramic tool, wherein the shell-bionic ceramic tool includes alternating stacks of ceramic powders with different components, pressing a ceramic green body using a cold briquetting method, carrying out pre-pressing once using a graphite indenter on a working surface thereof after each layer of the ceramic powder being loaded, and pressing a last layer using a graphite rod, and then pressing a whole ceramic green body with a certain pressure to promote a bonding of the layers of ceramic powder, which in turn gives a complex shape to an interface between the layers, increases a bonding area between the layers, and plays the role of hindering crack expansion, extending the crack expansion path, and improving the bonding strength of the interface; after then, hot-pressed sintering is used to densify the ceramic green body to obtain the shell-bionic ceramic tool.
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公开(公告)号：US20220314400A1
公开(公告)日：2022-10-06
申请号：US17367415
申请日：2021-07-04
Applicant: SHANDONG UNIVERSITY
Inventor： Dun LIU , Yifei ZHANG , Hongtao ZHU , Weijie ZHANG , Chuanzhen HUANG
Abstract: The present disclosure discloses an abrasive water jet full-section cutting type cutter head and application devices. The cutter head includes a cutter head body and a rotor eccentrically arranged on a working surface of the cutter head body. The rotor revolves with the cutter head body and also rotates about its own axis. At least one first nozzle is arranged on an edge of a working surface of the rotor. At least one group of second nozzles and at least one third nozzle are arranged on the working surface of the cutter head body, and the second nozzles and the third nozzle cooperate during the rotation of the cutter head body and the rotor, then a material to be cut is cut into a plurality of concentric rings, and the first nozzle cuts off the ring material to form fragments.
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Patent Agency Ranking
公开(公告)号：US20240227235A9
公开(公告)日：2024-07-11
申请号：US18168798
申请日：2023-02-14
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Yunpeng Feng , Hanlian Liu , Zhenyu Shi , Peng Yao , Dun Liu , Bin Zou , Hongtao Zhu , Zhen Wang , Jun Wang , Longhua Xu , Shuiquan Huang , Meina Qu , Zhengkai Xu , Minting Wang , Yabin Guan
IPC: B28B3/02 , C04B35/117 , C04B35/626 , C04B35/63 , C04B35/645
CPC classification number: B28B3/021 , C04B35/117 , C04B35/6261 , C04B35/6264 , C04B35/62655 , C04B35/6303 , C04B35/645 , C04B2235/3206 , C04B2235/3217 , C04B2235/3225 , C04B2235/3843 , C04B2235/3847 , C04B2235/404 , C04B2235/405 , C04B2235/604 , C04B2235/606 , C04B2235/75
Abstract: A method for preparing a shell-bionic ceramic tool and a shell-bionic ceramic tool, wherein the shell-bionic ceramic tool includes alternating stacks of ceramic powders with different components, pressing a ceramic green body using a cold briquetting method, carrying out pre-pressing once using a graphite indenter on a working surface thereof after each layer of the ceramic powder being loaded, and pressing a last layer using a graphite rod, and then pressing a whole ceramic green body with a certain pressure to promote a bonding of the layers of ceramic powder, which in turn gives a complex shape to an interface between the layers, increases a bonding area between the layers, and plays the role of hindering crack expansion, extending the crack expansion path, and improving the bonding strength of the interface; after then, hot-pressed sintering is used to densify the ceramic green body to obtain the shell-bionic ceramic tool.
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7.发明公开公开(公告)号：US20230364690A1
公开(公告)日：2023-11-16
申请号：US17900504
申请日：2022-08-31
Applicant: YANSHAN UNIVERSITY , SHANDONG UNIVERSITY
Inventor： Chuanzhen HUANG , Jinrui LI , Zhenyu SHI , Zhen WANG , Longhua XU , Dun LIU , Shuiquan HUANG , Xiaolan BAI , Yabin GUAN
CPC classification number: B23C5/20 , B23C5/28 , B23C2226/18
Abstract: A ceramic tool with integrated temperature sensing and cutting functions and preparation method and application thereof. The ceramic tool comprises a ceramic matrix, a positive thermoelectric layer and a negative thermoelectric layer being provided on two surfaces of the ceramic matrix; the ceramic matrix being formed by sintering a first matrix material, a first binding agent and a first reinforcing phase, and the thermoelectric layer being formed by sintering of a thermoelectric material; the first matrix material comprises one or more of Al2O3, Si3N4 and CBN; the first binding agent comprises one or more of Mo, Ni, Co, W and Cr; the first reinforcing phase comprises one or more of TiC, WC, SiC, MgO, Cr2O3, TiO2 and ZrO2; the thermoelectric material for the positive thermoelectric layer comprises ZrB2 and SiC; the thermoelectric material for the negative thermoelectric layer comprises ZrB2, SiC, and graphite.
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8.发明申请公开(公告)号：US20220105682A1
公开(公告)日：2022-04-07
申请号：US16479828
申请日：2018-10-17
Applicant: SHANDONG UNIVERSITY
Inventor： Chuanzhen HUANG , Zhen WANG , Jun WANG , Bin ZOU , Hanlian LIU , Hongtao ZHU , Peng YAO
Abstract: A self-rotation cleaning device has outer and inner housings, a workpiece rotating system, an ultrasonic cleaning system and a fluid perfusion system. The inner housing is in the outer housing in a horizontal direction. A cylindrical cavity is inside the inner housing. One end of the inner housing has a sealing cover detachably connected thereto, and the other end is closed. The workpiece rotating system is in the cavity for fixing a member to be cleaned, and realizes self-rotation of the member. The ultrasonic cleaning system supplies mechanical energy to the cleaning liquid in the inner housing to generate bubbles therein. The bubbles remove residual resin attached to the cleaned member surface by continuous vibration and burst. The fluid perfusion system provides self-rotation power for the cleaned member, and continuously delivers the cleaning liquid to the inside of the cleaned member, and the cleaning liquid is carried out after cleaning.
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公开(公告)号：US20250002660A1
公开(公告)日：2025-01-02
申请号：US18692195
申请日：2022-01-11
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Zhichao WANG , Hanlian LIU , Peng YAO , Wei WANG , Zhen WANG , Longhua XU , Shuiquan HUANG , Jun WANG , Hongtao ZHU , Bin ZOU
Abstract: A method for prepring a porous aerogel scaffold includes: adding a photoinitiator and polyethylene glycol diacrylate in a buffer solution, dissolving by heating and evenly mixing, adding Pluronic F127 into the mixed solution, and standing at a low temperature to obtain an aerogel scaffold material; printing a hydrogel scaffold by using a 3D printing technology, and performing UV irradiation so that a cross-linking of the hydrogel scaffold is caused to form a three-dimensional scaffold with a stable structure, performing low-temperature soaking to remove Pluronic F127, and then freeze drying the three-dimensional scaffold to obtain the porous aerogel scaffold. Wherein, Pluronic F127 serves as a sacrificial material which is removed after the 3D printing of the hydrogel scaffold is completed, and then a porous structure can be formed in the scaffold in combination with a freeze drying technology, which facilitates the survival, growth and proliferation of cells during the three-dimensional culture.
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10.发明公开公开(公告)号：US20240108784A1
公开(公告)日：2024-04-04
申请号：US18081964
申请日：2022-12-15
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Zhuang CHEN , Hanlian LIU , Peng YAO , Zhenyu SHI , Dun LIU , Hongtao ZHU , Bin ZOU , Zhen WANG , Minting WANG , Longhua XU , Shuiquan HUANG , Meina QU , Zhengkai XU , Yabin GUAN
IPC: A61L26/00 , B29C64/118 , B33Y10/00 , B33Y70/00 , B33Y80/00
CPC classification number: A61L26/008 , A61L26/0052 , B29C64/118 , B33Y10/00 , B33Y70/00 , B33Y80/00 , B29K2005/00 , B29L2031/753
Abstract: A hydrogel for cell-laden bioprinting, bioink, and a preparation method and an application thereof, relates to the technical field of biomedical polymer hydrogels. The hydrogel for cell-laden bioprinting is polymer gel formed by adding a cell-specific material into a matrix of alginate and gelatin and crosslinking and curing, wherein the cell-specific material is polypeptide selected according to different laden cells. The structures printed using the hydrogel may have the advantages such as adjustable mechanical properties, adjustable porosity, high biocompatibility, high printing accuracy, and high customizability, which may widely support the printing of human tissues and organs such as spinal cord, cartilage, and heart, and has good prospects for applications in tissue repair, organ transplantation and so on.
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