公开(公告)号：US20230232721A1

公开(公告)日：2023-07-20

申请号：US17893563

申请日：2022-08-23

Applicant: YANSHAN UNIVERSITY ,  SHANDONG UNIVERSITY

Inventor： Chuanzhen HUANG ,  Kai MENG ,  Zhenyu SHI ,  Zhen WANG ,  Longhua XU ,  Dun LIU ,  Shuiquan HUANG ,  Xiaolan BAI

IPC: H01L41/18 ,  H01L41/083 ,  H01L41/273 ,  H01L41/37 ,  B23B27/14 ,  C04B35/10 ,  C04B35/468 ,  C04B35/491 ,  C04B35/626 ,  C04B35/645 ,  C22C32/00 ,  C22C30/00 ,  C22C29/12

CPC classification number: H01L41/183 ,  H01L41/083 ,  H01L41/273 ,  H01L41/37 ,  B23B27/148 ,  C04B35/10 ,  C04B35/4684 ,  C04B35/491 ,  C04B35/6261 ,  C04B35/645 ,  C22C32/0005 ,  C22C30/00 ,  C22C29/12 ,  C04B2235/3217 ,  C04B2235/3206 ,  C04B2235/3236 ,  C04B2235/3249 ,  C04B2235/3843 ,  C04B2235/3826 ,  C04B2235/405 ,  C04B2235/6581

Abstract: A ceramic tool material, in particular with piezoelectric effect and a preparation method thereof, and a cutting tool. The ceramic tool material includes the following raw materials by weight: 30-70 parts of matrix material, 30-70 parts of piezoelectric material, 5-10 parts of binder, and 10-20 parts of reinforcing phase and can be made into cutting tools. The cutting tool has a piezoelectric effect and excellent mechanical properties and can convert the cutting force signal into the charge signal during machining. By collecting charge signals, a cutting force can be measured and ceramic cutting tool condition can be monitored. Cutting force measurement function and high mechanical properties are integrated. A ceramic tool material with piezoelectric effect can measure the cutting force on the premise by meeting the cutting performance requirements.

公开(公告)号：US20230364690A1

公开(公告)日：2023-11-16

申请号：US17900504

申请日：2022-08-31

Applicant: YANSHAN UNIVERSITY ,  SHANDONG UNIVERSITY

Inventor： Chuanzhen HUANG ,  Jinrui LI ,  Zhenyu SHI ,  Zhen WANG ,  Longhua XU ,  Dun LIU ,  Shuiquan HUANG ,  Xiaolan BAI ,  Yabin GUAN

IPC: B23C5/20 ,  B23C5/28

CPC classification number: B23C5/20 ,  B23C5/28 ,  B23C2226/18

Abstract: A ceramic tool with integrated temperature sensing and cutting functions and preparation method and application thereof. The ceramic tool comprises a ceramic matrix, a positive thermoelectric layer and a negative thermoelectric layer being provided on two surfaces of the ceramic matrix; the ceramic matrix being formed by sintering a first matrix material, a first binding agent and a first reinforcing phase, and the thermoelectric layer being formed by sintering of a thermoelectric material; the first matrix material comprises one or more of Al2O3, Si3N4 and CBN; the first binding agent comprises one or more of Mo, Ni, Co, W and Cr; the first reinforcing phase comprises one or more of TiC, WC, SiC, MgO, Cr2O3, TiO2 and ZrO2; the thermoelectric material for the positive thermoelectric layer comprises ZrB2 and SiC; the thermoelectric material for the negative thermoelectric layer comprises ZrB2, SiC, and graphite.

公开(公告)号：US20240302352A1

公开(公告)日：2024-09-12

申请号：US18182091

申请日：2023-03-10

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Zhuang CHEN ,  Hanlian LIU ,  Peng YAO ,  Dun LIU ,  Hongtao ZHU ,  Bin ZOU ,  Zhen WANG ,  Jun WANG ,  Longhua XU ,  Shuiquan HUANG ,  Meina QU ,  Zhengkai XU ,  Minting WANG ,  Yabin GUAN

IPC: G01N33/50 ,  B33Y70/00 ,  B33Y80/00 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797

CPC classification number: G01N33/5082 ,  B33Y70/00 ,  B33Y80/00 ,  C12N5/0618 ,  C12N5/0619 ,  C12N5/0623 ,  C12N2501/13 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2533/74

Abstract: A method of rapid constructing human cerebral cortical organoids by 3D bioprinting and an application including preparing microfluidic chips, preparation of hydrogel of human cerebral cortical organoids, and printing of human cerebral cortical organoids. The microfluidic chip comprises a mixed-flow channel layer, liquid pool layer, microporous array layer, human cerebral cortical organoid culture layer, and culture medium recovery layer; the human cerebral cortical organoid hydrogel has gelatin, alginate, and hyaluronic acid; printing directly human cerebral cortical organoids in microfluidic chips by FRESH printing method, obtaining human cerebral cortical organoid chips after packaging. The application directly constructs large-scale human cerebral cortex-like with three layers of mutually connected structures in situ in organ chip through 3D bioprinting, simulates cerebrospinal fluid circulation through perfusion culture.

公开(公告)号：US20220314400A1

公开(公告)日：2022-10-06

申请号：US17367415

申请日：2021-07-04

Applicant: SHANDONG UNIVERSITY

Inventor： Dun LIU ,  Yifei ZHANG ,  Hongtao ZHU ,  Weijie ZHANG ,  Chuanzhen HUANG

IPC: B24C1/04 ,  B24C7/00

Abstract: The present disclosure discloses an abrasive water jet full-section cutting type cutter head and application devices. The cutter head includes a cutter head body and a rotor eccentrically arranged on a working surface of the cutter head body. The rotor revolves with the cutter head body and also rotates about its own axis. At least one first nozzle is arranged on an edge of a working surface of the rotor. At least one group of second nozzles and at least one third nozzle are arranged on the working surface of the cutter head body, and the second nozzles and the third nozzle cooperate during the rotation of the cutter head body and the rotor, then a material to be cut is cut into a plurality of concentric rings, and the first nozzle cuts off the ring material to form fragments.

公开(公告)号：US20240108784A1

公开(公告)日：2024-04-04

申请号：US18081964

申请日：2022-12-15

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Zhuang CHEN ,  Hanlian LIU ,  Peng YAO ,  Zhenyu SHI ,  Dun LIU ,  Hongtao ZHU ,  Bin ZOU ,  Zhen WANG ,  Minting WANG ,  Longhua XU ,  Shuiquan HUANG ,  Meina QU ,  Zhengkai XU ,  Yabin GUAN

IPC: A61L26/00 ,  B29C64/118 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

CPC classification number: A61L26/008 ,  A61L26/0052 ,  B29C64/118 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  B29K2005/00 ,  B29L2031/753

Abstract: A hydrogel for cell-laden bioprinting, bioink, and a preparation method and an application thereof, relates to the technical field of biomedical polymer hydrogels. The hydrogel for cell-laden bioprinting is polymer gel formed by adding a cell-specific material into a matrix of alginate and gelatin and crosslinking and curing, wherein the cell-specific material is polypeptide selected according to different laden cells. The structures printed using the hydrogel may have the advantages such as adjustable mechanical properties, adjustable porosity, high biocompatibility, high printing accuracy, and high customizability, which may widely support the printing of human tissues and organs such as spinal cord, cartilage, and heart, and has good prospects for applications in tissue repair, organ transplantation and so on.

公开(公告)号：US20230405874A1

公开(公告)日：2023-12-21

申请号：US17941726

申请日：2022-09-09

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Xuefei LIU ,  Hanlian LIU ,  Peng YAO ,  Hongtao ZHU ,  Bin ZOU ,  Dun LIU ,  Jun WANG ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG

IPC: B28D5/04 ,  G02B1/118 ,  G02B1/113 ,  B23K26/0622

CPC classification number: B28D5/04 ,  G02B1/118 ,  G02B1/113 ,  B23K26/0624 ,  B23K2103/56

Abstract: A monocrystalline silicon micro-nano dual-scale anti-reflection texture and a preparation method therefor. The preparation method combines nanosecond-laser-assisted waterjet near-damage-free processing and femtosecond laser scanning, and subsurface damage caused by a re-cast layer phenomenon and a hot crack in a monocrystalline silicon laser texturing process can be effectively reduced by combining a nanosecond-laser-assisted waterjet near-damage-free processing technology and an ultra-short pulse femtosecond laser cold processing technology; and meanwhile, a micro-scale frame structure and a nano-scale structure can be flexibly modified respectively by adjusting nanosecond-laser-assisted waterjet technological parameters and femtosecond laser technological parameters, a geometry light trapping effect and an effective dielectric effect can be achieved in a micro-nano dual-scale hybrid structure at the same time, and surface reflection is reduced.

公开(公告)号：US20240067567A1

公开(公告)日：2024-02-29

申请号：US17955237

申请日：2022-09-28

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Zexin LI ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Dun LIU ,  Hongtao ZHU ,  Bin ZOU ,  Jun WANG ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG ,  Meina QU ,  Zhengkai XU

IPC: C04B35/117 ,  B23B27/14 ,  C04B35/626 ,  C04B35/645

CPC classification number: C04B35/117 ,  B23B27/148 ,  C04B35/6261 ,  C04B35/6264 ,  C04B35/62655 ,  C04B35/645 ,  C04B2235/3206 ,  C04B2235/3217 ,  C04B2235/3224 ,  C04B2235/3258 ,  C04B2235/3856 ,  C04B2235/3886 ,  C04B2235/606 ,  C04B2235/656 ,  C04B2235/6581 ,  C04B2235/9607

Abstract: An alumina-based ceramic tool material with low thermal expansion and a preparation process thereof, accordingly, the ceramic tool material may have both the high hardness of alumina ceramics after the hot pressing sintering, and reduces the thermal expansion coefficient of the overall ceramic material by adding the Sc2W3O12 as the negative thermal expansion phase, which improves the thermal shock resistance of ceramic tools in high-speed cutting engineering and meets the requirements of large temperature range during the machining of nickel-based superalloys. Moreover, the composite material does not use metal binder and has strong thermal stability even in the high-speed machining under extreme heat-force-chemistry coupling, so it has a high machining compatibility for nickel-based superalloys.

公开(公告)号：US20230405187A1

公开(公告)日：2023-12-21

申请号：US17939524

申请日：2022-09-07

Applicant: YANSHAN UNIVERSITY ,  SHANDONG UNIVERSITY

Inventor： Chuanzhen HUANG ,  Xu HAN ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Hongtao ZHU ,  Bin ZOU ,  Dun LIU ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG

IPC: A61L27/52 ,  C08J3/075 ,  C12N5/00 ,  A61L27/26 ,  B33Y70/00 ,  B33Y80/00 ,  B33Y40/00 ,  B33Y10/00

CPC classification number: A61L27/52 ,  C08J3/075 ,  C12N5/0062 ,  A61L27/26 ,  B33Y70/00 ,  B33Y80/00 ,  B33Y40/00 ,  B33Y10/00 ,  C08J2489/04 ,  C08J2301/28 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2533/78

Abstract: A composite hydrogel for light-cured 3D cell-laden printing and a preparation method and application thereof. The composite hydrogel of the present disclosure combines advantages of gelatin methacryloyl, sodium carboxymethylcellulose, hyaluronic acid-glutamic acid polymer, and the like. The provided composite hydrogel for 3D printing has the characteristics of low toxicity, good biocompatibility and adjustable mechanical properties, can provide cells with a three-dimensional living environment, promotes cell adhesion and migration on gradient scaffolds, and is suitable for tissue engineering scaffolds and cell-laden printing of tissues. The printing process of a scaffold is simple and can be completed within a short time, and the porosity and mechanical properties of the 3D printed hydrogel scaffold can be adjusted by adjusting the proportion of HA-Glu and Col in the hydrogel system.

公开(公告)号：US20230303453A1

公开(公告)日：2023-09-28

申请号：US17943596

申请日：2022-09-13

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Xinyao CUI ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Xiaolan BAI ,  Zhen WANG ,  Longhua XU ,  Dun LIU ,  Shuiquan HUANG ,  Hongtao ZHU ,  Bin ZOU

IPC: C04B35/58 ,  C04B35/626 ,  C04B35/645

CPC classification number: C04B35/58021 ,  C04B35/6261 ,  C04B35/645 ,  C04B35/6264 ,  C04B2235/3886 ,  C04B2235/3843 ,  C04B2235/3891 ,  C04B2235/405 ,  C04B2235/404 ,  C04B2235/75 ,  C04B2235/786 ,  C04B2235/785 ,  C04B2235/604 ,  C04B2235/6562 ,  C04B2235/6567 ,  B26D2001/002

Abstract: A crack self-healing functionally gradient material for ceramic cutting tools and a preparation method thereof. The material for ceramic cutting tools has a symmetrical gradient structure, and based on the percentage by mass, components of each layer include 50%-80% of Ti(C7,N3), 25%-5% of (W7,Ti3)C and 20%-0% of TiSi2; contents of components of layers that are symmetrical relative to a central layer are the same and a thickness is symmetrically distributed; a content of Ti(C7,N3) gradually increases from the surface layer to the central layer, contents of (W7,Ti3)C and Ti Si2 gradually decrease by 5% from the surface layer to the central layer, and the contents of Ni and Mo gradually increase from the surface layer to the central layer.

公开(公告)号：US20230279345A1

公开(公告)日：2023-09-07

申请号：US17851731

申请日：2022-06-28

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Zhichao WANG ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Dun LIU ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG ,  Minting WANG ,  Hongtao ZHU ,  Bin ZOU

IPC: C12N5/00 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/106

CPC classification number: C12N5/0068 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/106 ,  C12N2533/30 ,  B29L2031/7534

Abstract: A vascular structure-containing large-scale biological tissue and a construction method thereof. In the existing three-dimensional cell culture, it is contradictory for the elastic modulus of the scaffold material in ensuring structural stability and biocompatibility, and the vascular structure is required to provide channels for nutrient exchange when a large-scale structure is prepared. A cell-laden matrix material is poured into a hollow scaffold serving as a supporting scaffold. The overall stability of the scaffold structure can be ensured by regulating the mechanical properties of the supporting scaffold, thereby resolving the contradiction in ensuring structural stability and biocompatibility for the mechanical properties of the scaffold material in the conventional three-dimensional cell culture. A coaxially printing outer material contains a thermosensitive material. The removal of the outer thermosensitive material can increase the porosity of the vascular walls, and further increase the diffusion in the hollow vascular ducts.