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1.发明公开公开(公告)号：US20240302352A1
公开(公告)日：2024-09-12
申请号：US18182091
申请日：2023-03-10
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Zhuang CHEN , Hanlian LIU , Peng YAO , Dun LIU , Hongtao ZHU , Bin ZOU , Zhen WANG , Jun WANG , Longhua XU , Shuiquan HUANG , Meina QU , Zhengkai XU , Minting WANG , Yabin GUAN
IPC: G01N33/50 , B33Y70/00 , B33Y80/00 , C12N5/079 , C12N5/0793 , C12N5/0797
CPC classification number: G01N33/5082 , B33Y70/00 , B33Y80/00 , C12N5/0618 , C12N5/0619 , C12N5/0623 , C12N2501/13 , C12N2513/00 , C12N2533/54 , C12N2533/74
Abstract: A method of rapid constructing human cerebral cortical organoids by 3D bioprinting and an application including preparing microfluidic chips, preparation of hydrogel of human cerebral cortical organoids, and printing of human cerebral cortical organoids. The microfluidic chip comprises a mixed-flow channel layer, liquid pool layer, microporous array layer, human cerebral cortical organoid culture layer, and culture medium recovery layer; the human cerebral cortical organoid hydrogel has gelatin, alginate, and hyaluronic acid; printing directly human cerebral cortical organoids in microfluidic chips by FRESH printing method, obtaining human cerebral cortical organoid chips after packaging. The application directly constructs large-scale human cerebral cortex-like with three layers of mutually connected structures in situ in organ chip through 3D bioprinting, simulates cerebrospinal fluid circulation through perfusion culture.
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2.发明公开公开(公告)号：US20240216581A1
公开(公告)日：2024-07-04
申请号：US17911188
申请日：2021-09-17
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Xu HAN , Hanlian LIU , Peng YAO , Hongtao ZHU , Bin ZOU , Jun WANG
CPC classification number: A61L27/52 , A61L27/20 , A61L27/222 , B33Y10/00 , B33Y80/00 , C08J3/075 , C08J2305/04 , C08J2401/28 , C08J2405/00 , C08J2405/08
Abstract: A photocurable composite hydrogel matrix precursor, a preparation method thereof and a scaffold with same. The photocurable composite hydrogel matrix precursor includes gelatin methacrylate, sodium alginate, sodium carboxymethyl cellulose and chondroitin sulfate, where the mass ratio of a photoinitiator to the gelatin methacrylate to the sodium alginate to the sodium carboxymethyl cellulose to the chondroitin sulfate is (0.2-0.3):(8-10):(1-3):(0.6-0.8):(0.05-0.07). By adoption of the precursor, a cell-loaded printing hydrogel scaffold can be obtained through an extrusion-based 3D bio-printing technology, and the scaffold is controllable in form, good in moldability, high in precision, and has good stability; the biocompatibility and bioactivity are high, so that a good growing environment can be provided for fibroblasts; and the preparation process is simple and can be completed within a short time, moreover, the porosity and mechanical performance of the 3D printing hydrogel scaffold can be adjusted by adjusting the raw material ratio.
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公开(公告)号：US20220221384A1
公开(公告)日：2022-07-14
申请号：US17580358
申请日：2022-01-20
Inventor： Shanchao HU , Jing ZUO , Jianguo NING , Jun WANG , Yong GUO , Wenkai RU
IPC: G01N3/08
Abstract: The disclosure discloses an automatic simulation test bench and a test method for similar materials of top-coal caving mining. Wherein, the test bench includes a test bench base, a coal seam and strata simulation module, a coal releasing simulation module, a material recovery module, automatic mixing system and a central control system. The disclosure adopts modular construction to meet the requirements of similar material simulation test of top-coal caving mining under different geological conditions and mining technology to the greatest extent. The disclosure adopts automatic control, reduces the working intensity and operation difficulty of the test personnel, and reduces the influence of human factors on the test results. The disclosure adopts a lifting structural design, so as to meet the requirements of similar simulation test of top-coal caving mining under different mining and caving ratios.
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4.发明公开公开(公告)号：US20240067567A1
公开(公告)日：2024-02-29
申请号：US17955237
申请日：2022-09-28
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Zexin LI , Hanlian LIU , Zhenyu SHI , Peng YAO , Dun LIU , Hongtao ZHU , Bin ZOU , Jun WANG , Zhen WANG , Longhua XU , Shuiquan HUANG , Meina QU , Zhengkai XU
IPC: C04B35/117 , B23B27/14 , C04B35/626 , C04B35/645
CPC classification number: C04B35/117 , B23B27/148 , C04B35/6261 , C04B35/6264 , C04B35/62655 , C04B35/645 , C04B2235/3206 , C04B2235/3217 , C04B2235/3224 , C04B2235/3258 , C04B2235/3856 , C04B2235/3886 , C04B2235/606 , C04B2235/656 , C04B2235/6581 , C04B2235/9607
Abstract: An alumina-based ceramic tool material with low thermal expansion and a preparation process thereof, accordingly, the ceramic tool material may have both the high hardness of alumina ceramics after the hot pressing sintering, and reduces the thermal expansion coefficient of the overall ceramic material by adding the Sc2W3O12 as the negative thermal expansion phase, which improves the thermal shock resistance of ceramic tools in high-speed cutting engineering and meets the requirements of large temperature range during the machining of nickel-based superalloys. Moreover, the composite material does not use metal binder and has strong thermal stability even in the high-speed machining under extreme heat-force-chemistry coupling, so it has a high machining compatibility for nickel-based superalloys.
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5.发明公开公开(公告)号：US20230166342A1
公开(公告)日：2023-06-01
申请号：US17762960
申请日：2021-04-12
Applicant: SHANDONG UNIVERSITY
Inventor： Chuanzhen HUANG , Zhen CHEN , Hanlian LIU , Hongtao ZHU , Bin ZOU , Peng YAO , Jun WANG
IPC: B23C5/26
CPC classification number: B23C5/26 , B23C2210/0407 , B23C2210/54
Abstract: A milling machine fly-cutter with adjustable cutting-tool geometric angle and milling machine includes a fly-cutter plate body, a plurality of combination grooves are evenly set in the circumferential direction of the fly-cutter plate body, and adjusting assemblies are mounted in the combination grooves. Wherein, the adjusting assemblies include an adjusting block for rake angle and relief angle, an adjusting block for tool cutting edge angle and minor cutting edge angle, an adjusting block for tool cutting edge inclination angle. A first side of the adjusting block is attached with a cutter handle, and a second side is connected with the adjusting block for rake angle and relief angle by the adjusting block for tool cutting edge angle and minor cutting edge angle. The milling machine fly-cutter realizes adjustment of the geometric angles of cutting tool, and is able to adapt to cutter handles of a variety of different specifications.
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Patent Agency Ranking
公开(公告)号：US20220404238A1
公开(公告)日：2022-12-22
申请号：US17618692
申请日：2021-01-15
Applicant: SHANDONG UNIVERSITY
Inventor： Chuanzhen HUANG , Binghao LI , Hanlian LIU , Hongtao ZHU , Bin ZOU , Peng YAO , Jun WANG
Abstract: A BTA drilling quick-stop device (QSD) and a method, wherein the BTA drilling QSD includes a base. The base includes a hollow cavity. A side portion of the base has an opening communicating with the hollow cavity. The opening is closed by a through cover. A horizontally movable fixture is disposed in the hollow cavity. A stopper is disposed at a top portion of the base. A bottom portion of the stopper is disposed lower than a top portion of the fixture to stop the fixture from moving during processing. An elastic element is disposed between the through cover and a side portion of the fixture to push the fixture to move after processing.
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7.发明申请公开(公告)号：US20220105682A1
公开(公告)日：2022-04-07
申请号：US16479828
申请日：2018-10-17
Applicant: SHANDONG UNIVERSITY
Inventor： Chuanzhen HUANG , Zhen WANG , Jun WANG , Bin ZOU , Hanlian LIU , Hongtao ZHU , Peng YAO
Abstract: A self-rotation cleaning device has outer and inner housings, a workpiece rotating system, an ultrasonic cleaning system and a fluid perfusion system. The inner housing is in the outer housing in a horizontal direction. A cylindrical cavity is inside the inner housing. One end of the inner housing has a sealing cover detachably connected thereto, and the other end is closed. The workpiece rotating system is in the cavity for fixing a member to be cleaned, and realizes self-rotation of the member. The ultrasonic cleaning system supplies mechanical energy to the cleaning liquid in the inner housing to generate bubbles therein. The bubbles remove residual resin attached to the cleaned member surface by continuous vibration and burst. The fluid perfusion system provides self-rotation power for the cleaned member, and continuously delivers the cleaning liquid to the inside of the cleaned member, and the cleaning liquid is carried out after cleaning.
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8.发明申请公开(公告)号：US20200319070A1
公开(公告)日：2020-10-08
申请号：US16652961
申请日：2019-02-28
Inventor： Xuesheng LIU , Shilin SONG , Yunliang TAN , Deyuan FAN , Jianguo NING , Qingheng GU , Ning JIANG , Jun WANG , Qiang XU
Abstract: A rock mechanics test system with impact loading-confining pressure unloading and its usage method. The test system includes bearing frame unit, axial compression loading unit, impact loading unit and confining pressure loading unit. The bearing frame unit includes pedestal, column and cross beam. The column is vertically installed on both sides of the upper surface of the pedestal, and the cross beam is horizontally fixed on the upper part of the column. The axial compression loading unit is fixed at the middle position of the upper surface of the pedestal and is used to exert the axial bottom-up pressure to the sample. The impact loading unit is fixed on the cross beam and is used to exert the axial top-down impact load on the sample.
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公开(公告)号：US20250002660A1
公开(公告)日：2025-01-02
申请号：US18692195
申请日：2022-01-11
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Zhichao WANG , Hanlian LIU , Peng YAO , Wei WANG , Zhen WANG , Longhua XU , Shuiquan HUANG , Jun WANG , Hongtao ZHU , Bin ZOU
Abstract: A method for prepring a porous aerogel scaffold includes: adding a photoinitiator and polyethylene glycol diacrylate in a buffer solution, dissolving by heating and evenly mixing, adding Pluronic F127 into the mixed solution, and standing at a low temperature to obtain an aerogel scaffold material; printing a hydrogel scaffold by using a 3D printing technology, and performing UV irradiation so that a cross-linking of the hydrogel scaffold is caused to form a three-dimensional scaffold with a stable structure, performing low-temperature soaking to remove Pluronic F127, and then freeze drying the three-dimensional scaffold to obtain the porous aerogel scaffold. Wherein, Pluronic F127 serves as a sacrificial material which is removed after the 3D printing of the hydrogel scaffold is completed, and then a porous structure can be formed in the scaffold in combination with a freeze drying technology, which facilitates the survival, growth and proliferation of cells during the three-dimensional culture.
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10.发明公开公开(公告)号：US20230405874A1
公开(公告)日：2023-12-21
申请号：US17941726
申请日：2022-09-09
Applicant: SHANDONG UNIVERSITY , YANSHAN UNIVERSITY
Inventor： Chuanzhen HUANG , Xuefei LIU , Hanlian LIU , Peng YAO , Hongtao ZHU , Bin ZOU , Dun LIU , Jun WANG , Zhen WANG , Longhua XU , Shuiquan HUANG
IPC: B28D5/04 , G02B1/118 , G02B1/113 , B23K26/0622
CPC classification number: B28D5/04 , G02B1/118 , G02B1/113 , B23K26/0624 , B23K2103/56
Abstract: A monocrystalline silicon micro-nano dual-scale anti-reflection texture and a preparation method therefor. The preparation method combines nanosecond-laser-assisted waterjet near-damage-free processing and femtosecond laser scanning, and subsurface damage caused by a re-cast layer phenomenon and a hot crack in a monocrystalline silicon laser texturing process can be effectively reduced by combining a nanosecond-laser-assisted waterjet near-damage-free processing technology and an ultra-short pulse femtosecond laser cold processing technology; and meanwhile, a micro-scale frame structure and a nano-scale structure can be flexibly modified respectively by adjusting nanosecond-laser-assisted waterjet technological parameters and femtosecond laser technological parameters, a geometry light trapping effect and an effective dielectric effect can be achieved in a micro-nano dual-scale hybrid structure at the same time, and surface reflection is reduced.
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