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公开(公告)号：US20160038938A1
公开(公告)日：2016-02-11
申请号：US14775338
申请日：2014-03-13
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： Dafeng Chen , James E. Rasmussen , Manish Deshpande
IPC: B01L3/00
CPC classification number: B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/523 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , F16K99/003 , F16K2099/008 , F16K2099/0084
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
Abstract translation: 微流体产品袋组件可用于微流体芯片。 微流体产品袋可以包括围绕内室的袋，并且具有破裂部分和位于内室内的内膜。 内膜可以将内室分离成第一腔和第二腔。 试剂可以定位在第一腔和/或第二腔内。 微流体产品袋组件还可以包括破裂结构。 破裂结构可以被配置为选择性地破坏微流体产品袋的破裂部分。
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公开(公告)号：US20170120164A1
公开(公告)日：2017-05-04
申请号：US15318898
申请日：2015-06-16
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Dafeng Chen , James E. Rasmussen , Manish Deshpande
IPC: B01D19/00
CPC classification number: B01D19/0031 , B01D19/0063
Abstract: A fluidic device and a method for degassing a fluidic device are presented. The fluidic device includes a plurality of fluidic components such as channels, chambers, and integrated valves and pumps, etc. A porous membrane is disposed on a degassing area of the fluidic device for removing gas (such as, for example, bubbles) contained in a liquid. A fluid control device monitors a pressure profile indicating a pressure in the fluidic device over time and applies a pressure differential between two sides of the membrane when activated. The membrane is permeable to gas in the fluidic device and is impermeable to liquids through the pores under the pressure differential. The disclosed method enables degassing large volume of gas at a high flow rate and provides a bubble free filling in a fluidic device which is critical to precision sample metering, mixing, fluid control, reaction, and detection, etc.
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公开(公告)号：US20160318019A1
公开(公告)日：2016-11-03
申请号：US15206669
申请日：2016-07-11
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： David J. Ledden , Dafeng Chen , James E. Rasmussen
CPC classification number: B01L3/502753 , B01L3/502715 , B01L3/502738 , B01L2200/0605 , B01L2200/14 , B01L2200/142 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/161 , B01L2400/0688 , B01L2400/084 , G01N1/30
Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.
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公开(公告)号：US11235321B2
公开(公告)日：2022-02-01
申请号：US16598363
申请日：2019-10-10
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Dafeng Chen , James E. Rasmussen , Manish Deshpande
IPC: B01L3/00
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
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公开(公告)号：US10105701B2
公开(公告)日：2018-10-23
申请号：US15206669
申请日：2016-07-11
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： David J. Ledden , Dafeng Chen , James E. Rasmussen
Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.
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Patent Agency Ranking
公开(公告)号：US09416776B2
公开(公告)日：2016-08-16
申请号：US14776172
申请日：2014-03-13
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： David J. Ledden , Dafeng Chen , James E. Rasmussen
IPC: B01L3/00 , B01L3/02 , G01N33/00 , G01N15/06 , G01N33/48 , F04B13/00 , F04B17/03 , G01N35/10 , B05B1/02
CPC classification number: F04B13/00 , B01L3/502738 , B01L3/502753 , B01L2200/0652 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/161 , B01L2400/0688 , B01L2400/084 , B05B1/02 , F04B17/03 , G01N35/1095
Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.
Abstract translation: 具有用于分析流体样品（例如血液）的多个微通道的微流体分配装置。 微流体分配装置具有流体样品入口端口，流体样品的子样本从该流体样本入口端口分配到多个微通道，在该微通道中流体子样品被处理以供测试装置分析。
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公开(公告)号：US20200038855A1
公开(公告)日：2020-02-06
申请号：US16598363
申请日：2019-10-10
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Dafeng Chen , James E. Rasmussen , Manish Deshpande
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
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公开(公告)号：US10441951B2
公开(公告)日：2019-10-15
申请号：US14775338
申请日：2014-03-13
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Dafeng Chen , James E. Rasmussen , Manish Deshpande
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
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公开(公告)号：US10391425B2
公开(公告)日：2019-08-27
申请号：US15318898
申请日：2015-06-16
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： Dafeng Chen , James E. Rasmussen , Manish Deshpande
Abstract: A fluidic device and a method for degassing a fluidic device are presented. The fluidic device includes a plurality of fluidic components such as channels, chambers, and integrated valves and pumps, etc. A porous membrane is disposed on a degassing area of the fluidic device for removing gas (such as, for example, bubbles) contained in a liquid. A fluid control device monitors a pressure profile indicating a pressure in the fluidic device over time and applies a pressure differential between two sides of the membrane when activated. The membrane is permeable to gas in the fluidic device and is impermeable to liquids through the pores under the pressure differential. The disclosed method enables degassing large volume of gas at a high flow rate and provides a bubble free filling in a fluidic device which is critical to precision sample metering, mixing, fluid control, reaction, and detection, etc.
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公开(公告)号：US20150352548A1
公开(公告)日：2015-12-10
申请号：US14763588
申请日：2014-01-27
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： Manish Deshpande , James E. Rasmussen , Dafeng Chen
IPC: B01L3/00
CPC classification number: B01L3/5027 , B01L3/545 , B01L2200/04 , B01L2200/14 , B01L2300/021 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655
Abstract: Microfluidic chips may include one or more microfluidic elements and one or more channels providing fluid communication throughout the microfluidic chip. The microfluidic chips may also include an identifier for identifying a predetermined configuration of the one or more microfluidic elements and the one or more channels from a set of predetermined different configurations of the one or more microfluidic elements and the one or more channels.
Abstract translation: 微流控芯片可以包括一个或多个微流体元件和一个或多个通道，提供贯穿整个微流体芯片的流体连通。 微流体芯片还可以包括用于从一个或多个微流体元件和一个或多个通道的一组预定的不同配置中识别一个或多个微流体元件和一个或多个通道的预定配置的标识符。
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