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公开(公告)号:US06482638B1
公开(公告)日:2002-11-19
申请号:US09708916
申请日:2000-11-08
IPC分类号: C12M134
CPC分类号: B01J19/0046 , B01J2219/00495 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B29C35/0272 , B29C35/0805 , B29C61/02 , B29C61/0625 , B29C2035/0855 , C40B40/06 , C40B60/14
摘要: Articles, such as high density arrays, on heat-relaxable substrates that can be relaxed by exposure to thermal energy are disclosed, along with methods of manufacturing the arrays, and systems/apparatus for relaxing arrays using electromagnetic energy. The arrays may themselves include electromagnetic energy sensitive material in their construction, in which case exposure of the arrays to suitable electromagnetic energy can provide the thermal energy required to cause the arrays to relax. In other embodiments, the arrays may not include an electromagnetic energy sensitive material in their construction, in which case the arrays may be heated indirectly, i.e., by locating the arrays within a system or apparatus that includes an electromagnetic energy sensitive material and transferring the thermal energy from the electromagnetic energy sensitive material to the array by, e.g., conduction.
摘要翻译: 公开了诸如高密度阵列的物品,其可以通过暴露于热能而放松的热松弛基底上,以及制造阵列的方法以及使用电磁能量放松阵列的系统/装置。 阵列本身可以包括其结构中的电磁能量敏感材料,在这种情况下,阵列暴露于合适的电磁能可以提供使阵列放松所需的热能。 在其他实施例中,阵列在其结构中可以不包括电磁能量敏感材料,在这种情况下,阵列可以间接加热,即通过将阵列定位在包括电磁能量敏感材料并传递热量的系统或装置内 通过例如导电从电磁能敏感材料到阵列的能量。
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公开(公告)号:US06548607B2
公开(公告)日:2003-04-15
申请号:US10060798
申请日:2002-01-30
IPC分类号: C08F830
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要: High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
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3.
公开(公告)号:US07189842B2
公开(公告)日:2007-03-13
申请号:US10167204
申请日:2002-06-11
IPC分类号: C07H21/00
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要: High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
摘要翻译: 高密度,小型化阵列,包括高表面积。 所描述的阵列包括具有连接剂涂层的底物,以及附着在基材上的反应物的阵列。 制造高密度反应物阵列的方法。 这些方法包括使用取向的热收缩膜和弹性体材料。 使用连接剂官能化底物的方法用于随后的反应物固定也在本文中公开。
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公开(公告)号:US06593089B2
公开(公告)日:2003-07-15
申请号:US09909585
申请日:2001-07-20
IPC分类号: C12Q168
CPC分类号: B41M3/00 , B01J19/0046 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00664
摘要: The present invention provides high-density arrays including mask layers and methods of manufacturing the same. The arrays are formed on a polymeric substrate and include a mask layer. Various linking agents, linking agent coatings, and/or reactants may be provided on the mask layer. Where present, the linking agents and reactants preferably operate together to capture a desired analyte which can then be detected based on an electromagnetic signal, e.g., fluorescence, that is emitted by the analyte in response to excitation energy incident on the array. With the mask layer in place, the signal-to-background ratio provided by the arrays can be increased.
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5.
公开(公告)号:US5958782A
公开(公告)日:1999-09-28
申请号:US810969
申请日:1997-02-27
申请人: James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
发明人: James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
IPC分类号: G01N21/64 , C07D498/18 , C09B23/10 , G01N31/22 , G01N33/20 , G01N33/487
CPC分类号: C07D498/18 , C09B23/102 , G01N31/22 , G01N31/221
摘要: A fluorescent ionophoric compound is disclosed that includes a complexing moiety, such as a cryptand or crown-ether portion, and a fluorescing moiety such as a coumarin portion. The coumarin portion may be substituted at the 3-position with an electron withdrawing or polarizable group such as a substituted aromatic group or a substituted heterocyclic group having a heteroatom in at least one of its alpha positions. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.
摘要翻译: 公开了一种荧光离子化合物,其包括络合部分,例如穴状或冠醚部分,以及荧光部分如香豆素部分。 香豆素部分可以在3位被吸电子或可极化基团取代,例如取代的芳基或在其α位中的至少一个具有杂原子的取代的杂环基。 具有良好的光稳定性的化合物可以通过方便的共价连接点并入阳离子感应复合结构中。
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6.
公开(公告)号:US06841258B2
公开(公告)日:2005-01-11
申请号:US10060799
申请日:2002-01-30
IPC分类号: G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N33/543 , G01N37/00 , B32B13/12
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要: High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
摘要翻译: 高密度,小型化阵列,包括高表面积。 所描述的阵列包括具有连接剂涂层的底物,以及附着在基材上的反应物的阵列。 制造高密度反应物阵列的方法。 这些方法包括使用取向的热收缩膜和弹性体材料。 使用连接剂官能化底物的方法用于随后的反应物固定也在本文中公开。
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公开(公告)号:US06573338B2
公开(公告)日:2003-06-03
申请号:US10060794
申请日:2002-01-30
IPC分类号: C08F870
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要: High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
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公开(公告)号:US06881538B1
公开(公告)日:2005-04-19
申请号:US09519450
申请日:2000-03-05
申请人: Louis C. Haddad , Moses M. David , Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen , James I. Hembre
发明人: Louis C. Haddad , Moses M. David , Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen , James I. Hembre
IPC分类号: G01N33/53 , B01J19/00 , C08J7/04 , C08J7/12 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/02 , C40B40/06 , C40B50/06 , G01N37/00 , C12M1/36 , G01B7/16 , G01N15/06
CPC分类号: C08J7/12 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24975
摘要: Materials for use in miniaturized arrays, the arrays, and methods of manufacturing. Materials for making arrays described include a substrate with a silicon-containing layer, optionally with linking agents and reactants.
摘要翻译: 用于小型化阵列的材料,阵列和制造方法。 制备阵列的材料包括具有含硅层的基底,任选地具有连接剂和反应物。
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公开(公告)号:US06783838B2
公开(公告)日:2004-08-31
申请号:US09845946
申请日:2001-04-30
申请人: Patrick L. Coleman , Kurt J. Halverson , James I. Hembre , Sanjay L. Patil , Anila Prabhu , Raj Rajagopal , Jerald K. Rasmussen , Barbara C. Swenson , Patrick S. Quint
发明人: Patrick L. Coleman , Kurt J. Halverson , James I. Hembre , Sanjay L. Patil , Anila Prabhu , Raj Rajagopal , Jerald K. Rasmussen , Barbara C. Swenson , Patrick S. Quint
IPC分类号: B23B500
CPC分类号: B82Y30/00 , B01J2219/00351 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/545 , G01N33/548 , Y10S530/81 , Y10S530/816 , Y10T428/24355 , Y10T428/24446 , Y10T428/24628 , Y10T428/263 , Y10T428/264 , Y10T428/31725 , Y10T428/31757 , Y10T428/31855 , Y10T436/2575
摘要: A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed.
摘要翻译: 公开了具有包括可收缩聚合物膜,离子涂层和任选的水凝胶的离子表面的涂覆层压板。 公开了一种将样品分子从基质转移到具有离子表面的涂覆层压体的方法。
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公开(公告)号:US06664060B2
公开(公告)日:2003-12-16
申请号:US09910392
申请日:2001-07-20
IPC分类号: C07H2104
CPC分类号: B41M3/00 , B01J19/0046 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00664
摘要: The present invention provides high-density arrays including mask layers and methods of manufacturing the same. The arrays are formed on a polymeric substrate and include a mask layer. Various linking agents, linking agent coatings, and/or reactants may be provided on the mask layer. Where present, the linking agents and reactants preferably operate together to capture a desired analyte which can then be detected based on an electromagnetic signal, e.g., fluorescence, that is emitted by the analyte in response to excitation energy incident on the array. With the mask layer in place, the signal-to-background ratio provided by the arrays can be increased.
摘要翻译: 本发明提供了包括掩模层的高密度阵列及其制造方法。 阵列形成在聚合物基底上并包括掩模层。 可以在掩模层上提供各种连接剂,交联剂涂层和/或反应物。 当存在时,连接剂和反应物优选一起操作以捕获所需的分析物,然后可以基于由分析物响应于入射到阵列上的激发能量而发射的电磁信号(例如荧光)而被检测。 通过掩模层就位,由阵列提供的信号与背景比可以增加。
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