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公开(公告)号：US6165991A
公开(公告)日：2000-12-26
申请号：US80963
申请日：1998-05-19
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C12N9/12 , C12N15/31 , C12N15/54 , G01N33/569 , C07H21/00 , C12N15/63
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , C12N9/1205 , C12N9/1223 , G01N2800/52
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase Polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase Polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US6165992A
公开(公告)日：2000-12-26
申请号：US81689
申请日：1998-05-20
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/40 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/31 , C12Q1/02 , C12R1/46 , G01N33/50 , C07H21/00 , C12N15/62 , C12N15/63
CPC分类号： C12N9/1223 , A61K38/00 , A61K48/00 , G01N33/5005 , G01N2800/52
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06218528B1
公开(公告)日：2001-04-17
申请号：US09078691
申请日：1998-05-14
申请人： Nicola G Wallis , Min Wang , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Alison Frances Chalker , David John Holmes , Karen A Ingraham , Deborah D Jaworski , Jennifer Ray , Lisa K Shilling
发明人： Nicola G Wallis , Min Wang , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Alison Frances Chalker , David John Holmes , Karen A Ingraham , Deborah D Jaworski , Jennifer Ray , Lisa K Shilling
IPC分类号： C07H2104
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C12Y101/01158
摘要： The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了MurB多肽和编码MurB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用MurB多肽筛选抗菌化合物的方法。
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公开(公告)号：US6162619A
公开(公告)日：2000-12-19
申请号：US81686
申请日：1998-05-20
申请人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
CPC分类号： C12N9/1205
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06225457B1
公开(公告)日：2001-05-01
申请号：US09305001
申请日：1999-05-04
申请人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07H2104
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码murF2多肽的murF2多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用murF2多肽筛选抗菌化合物的方法。
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公开(公告)号：US07202071B2
公开(公告)日：2007-04-10
申请号：US10437581
申请日：2003-05-14
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06228625B1
公开(公告)日：2001-05-08
申请号：US09273686
申请日：1999-03-22
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12Q1/6876 , A61K38/00 , C07K14/3156
摘要： The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了metK多肽和编码metK多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用metK多肽来筛选抗菌化合物的方法。
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公开(公告)号：US06268177B1
公开(公告)日：2001-07-31
申请号：US09285576
申请日：1999-04-02
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N1500
CPC分类号： C12N9/1077
摘要： The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了ndp多肽和编码ndp多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ndp多肽筛选抗菌化合物的方法。
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公开(公告)号：US06245891B1
公开(公告)日：2001-06-12
申请号：US09285515
申请日：1999-04-02
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07K100
CPC分类号： C07K14/3156
摘要： The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码nusB多肽的nusB多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用nusB多肽筛选抗菌化合物的方法。
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10.发明授权Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae 有权编码来自肺炎链球菌的tRNA甲基转移酶的多核苷酸
公开(公告)号：US6165764A
公开(公告)日：2000-12-26
申请号：US274825
申请日：1999-03-23
申请人： David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker
发明人： David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides tRNA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trmD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供tRNA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用trmD多肽筛选抗菌化合物的方法。
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