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    Method And Apparatus For Measuring Particle Characteristics through Mass Detection
    4.
    发明申请
    Method And Apparatus For Measuring Particle Characteristics through Mass Detection 有权
    通过质量检测测量粒子特性的方法和装置

    公开(公告)号：US20090044608A1

    公开(公告)日：2009-02-19

    申请号：US12087495

    申请日：2007-10-11

    申请人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

    发明人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

    IPC分类号： G01N29/22

    CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

    摘要： Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

    摘要翻译： 测量目标粒子性质的方法。 校准悬浮微通道谐振器以确定检测到的质量和谐振器的谐振频率偏移之间的关系。 目标颗粒悬浮在流体中并被引入到谐振器中，并且测量由于颗粒引起的谐振器频率偏移。 目标粒子质量由共振器频率偏移，目标粒子密度和流体密度计算。 从计算出的目标粒子质量确定目标粒子性质如尺寸或体积。

    Method and apparatus for measuring particle characteristics through mass detection
    6.
    发明授权
    Method and apparatus for measuring particle characteristics through mass detection 有权
    通过质量检测测量颗粒特性的方法和装置

    公开(公告)号：US08087284B2

    公开(公告)日：2012-01-03

    申请号：US12087495

    申请日：2007-10-11

    申请人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

    发明人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

    IPC分类号： G01N9/00

    CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

    摘要： Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

    摘要翻译： 测量目标粒子性质的方法。 校准悬浮微通道谐振器以确定检测到的质量和谐振器的谐振频率偏移之间的关系。 目标颗粒悬浮在流体中并被引入到谐振器中，并且测量由于颗粒引起的谐振器频率偏移。 目标粒子质量由共振器频率偏移，目标粒子密度和流体密度计算。 从计算出的目标粒子质量确定目标粒子性质如尺寸或体积。

    Monitoring heparin by microelectronic devices
    9.
    发明申请
    Monitoring heparin by microelectronic devices 审中-公开
    通过微电子器件监测肝素

    公开(公告)号：US20070212786A1

    公开(公告)日：2007-09-13

    申请号：US11540695

    申请日：2006-09-29

    申请人： Scott Manalis ,  Tzu Loh ,  Michel Godin ,  Nebojsa Milovic ,  Jonathan Behr ,  Aarthi Chandrasekaran ,  Ram Sasisekharan

    发明人： Scott Manalis ,  Tzu Loh ,  Michel Godin ,  Nebojsa Milovic ,  Jonathan Behr ,  Aarthi Chandrasekaran ,  Ram Sasisekharan

    IPC分类号： G01N33/86

    CPC分类号： C12Q1/56 ,  B01L3/5027 ,  G01N27/4145 ,  G01N2333/8128

    摘要： In one aspect, the present invention provides a device and method for real-time, direct detection of heparin in buffer and in serum comprising a microfluidic field-effect device as an affinity biosensor. The sensor is based on an electrolyte-insulator-silicon structure, and is manufactured by a standard high-yield silicon microfabrication process. The binding of heparin to the sensor surface induces a change in the insulator-electrolyte surface potential, which is measured as a change in sensor capacitance. To ensure the binding selectivity, protamine and antithrombin III are used as affinity probes.

    摘要翻译： 一方面，本发明提供了用于在缓冲液和血清中实时，直接检测肝素的装置和方法，其包括作为亲和生物传感器的微流场效应装置。 该传感器基于电解质 - 绝缘体 - 硅结构，并通过标准的高产率硅微细加工工艺制造。 肝素与传感器表面的结合导致绝缘体 - 电解质表面电位的变化，其被测量为传感器电容的变化。 为了确保结合选择性，使用鱼精蛋白和抗凝血酶III作为亲和探针。