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    RECOMBINANT ADENOVIRUS COMPRISING TISSUE-SPECIFIC PROMOTER AND TUMOR-TARGETING TRANS-SPLICING RIBOZYME AND USES THEREOF
    1.
    发明申请
    RECOMBINANT ADENOVIRUS COMPRISING TISSUE-SPECIFIC PROMOTER AND TUMOR-TARGETING TRANS-SPLICING RIBOZYME AND USES THEREOF 审中-公开
    包含组织特异性促进剂和肿瘤靶向转移性RIBOZYME的重组腺病毒及其用途

    公开(公告)号：US20110256524A1

    公开(公告)日：2011-10-20

    申请号：US12599671

    申请日：2008-08-27

    申请人： Seong-Wook Lee ,  Min-Sun Song ,  In-Hoo Kim ,  Jin-Sook Jeong

    发明人： Seong-Wook Lee ,  Min-Sun Song ,  In-Hoo Kim ,  Jin-Sook Jeong

    IPC分类号： C12Q1/70 ,  C12N7/01

    CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N15/86 ,  C12N2310/124 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2840/445

    摘要： Disclosed herein are a recombinant adenovirus comprising tissue-specific promoters and trans-splicing ribozymes targeting tumor-specific genes, and uses thereof. More specifically, disclosed herein are a recombinant adenovirus comprising (1) a tissue-specific promoter, (2) a trans-splicing ribozyme acting on tumor-specific genes operably linked to the promoter, and (3) a therapeutic or reporter gene linked to 3′ exon of the ribozyme, an anticancer pharmaceutical composition comprising the same, and a composition for cancer diagnosis comprising the same.The recombinant adenovirus exhibits high specificity and significantly improved therapeutic efficacy to gene targeted tissues. Accordingly, the recombinant adenovirus is useful as a gene delivery vector for anticancer agents or cancer diagnostics.

    摘要翻译： 本文公开了包含靶向肿瘤特异性基因的组织特异性启动子和反式剪接核酶的重组腺病毒及其用途。 更具体地，本文公开了一种重组腺病毒，其包含（1）组织特异性启动子，（2）作用于与启动子可操作地连接的肿瘤特异性基因的反式剪接核酶，和（3）与 3'外显子，包含其的抗癌药物组合物和包含其的用于癌症诊断的组合物。 重组腺病毒表现出高特异性，并显着改善了对基因靶向组织的治疗功效。 因此，重组腺病毒可用作抗癌剂或癌症诊断的基因递送载体。

    PHOTOSENSITIZER-METAL NANOPARTICLE COMPLEX AND COMPOSITION CONTAINING THE COMPLEX FOR PHOTODYNAMIC THERAPY OR DIAGNOSIS
    7.
    发明申请
    PHOTOSENSITIZER-METAL NANOPARTICLE COMPLEX AND COMPOSITION CONTAINING THE COMPLEX FOR PHOTODYNAMIC THERAPY OR DIAGNOSIS 有权
    含光复合物的光敏金属纳米复合物及其组合物用于光化学治疗或诊断

    公开(公告)号：US20110293728A1

    公开(公告)日：2011-12-01

    申请号：US12665013

    申请日：2009-10-08

    申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

    发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

    IPC分类号： A61K9/14 ,  A61P35/00 ,  A61K38/10 ,  A61K38/08 ,  C07K7/06 ,  C07K7/08

    CPC分类号： A61K47/48861 ,  A61K41/0071 ,  A61K47/64 ,  A61K47/6923 ,  A61K49/0017 ,  A61K49/0065

    摘要： Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.

    摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒复合物和用于光动力学治疗或诊断的组合物。 复合物包括光敏剂，金属纳米颗粒和连接光敏剂与金属纳米颗粒的骨架。 骨架具有能够被蛋白酶特异性降解的多肽底物。 当将复合物施用于患者时，由于光敏剂和金属纳米颗粒之间的共振能量转移，共轭光敏剂的荧光和活性氧的产生被抑制在正常组织中，而在肿瘤组织中，荧光和活性氧的产生 从释放的光敏剂被激活，从而有效地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用蛋白酶激活的光敏剂 - 金属纳米颗粒复合物进一步提高肿瘤诊断的准确性。

    Photosensitizer-metal nanoparticle complex and composition containing the complex for photodynamic therapy or diagnosis
    8.
    发明授权
    Photosensitizer-metal nanoparticle complex and composition containing the complex for photodynamic therapy or diagnosis 有权
    光敏剂 - 金属纳米粒子复合物和含有光动力学治疗或诊断复合物的组合物

    公开(公告)号：US09339557B2

    公开(公告)日：2016-05-17

    申请号：US12665013

    申请日：2009-10-08

    申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

    发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  In-Hoo Kim ,  Jin-Young Park

    IPC分类号： A61K51/00 ,  A61K49/00 ,  A61B5/00 ,  A61K39/00 ,  C07D345/00 ,  C07B47/00 ,  C07D225/00 ,  C07D295/00 ,  A61K47/48 ,  A61K41/00 ,  C12N9/00

    CPC分类号： A61K47/48861 ,  A61K41/0071 ,  A61K47/64 ,  A61K47/6923 ,  A61K49/0017 ,  A61K49/0065

    摘要： Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.

    摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒复合物和用于光动力学治疗或诊断的组合物。 复合物包括光敏剂，金属纳米颗粒和连接光敏剂与金属纳米颗粒的骨架。 骨架具有能够被蛋白酶特异性降解的多肽底物。 当将复合物施用于患者时，由于光敏剂和金属纳米颗粒之间的共振能量转移，共轭光敏剂的荧光和活性氧的产生被抑制在正常组织中，而在肿瘤组织中，荧光和活性氧的产生 从释放的光敏剂被激活，从而有效地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用蛋白酶激活的光敏剂 - 金属纳米颗粒复合物进一步提高肿瘤诊断的准确性。

    Photosensitizer-metal nanoparticle charge complex and composition containing the complex for photodynamic therapy or diagnosis
    9.
    发明授权
    Photosensitizer-metal nanoparticle charge complex and composition containing the complex for photodynamic therapy or diagnosis 有权
    光敏剂 - 金属纳米粒子电荷复合物和含有光动力学治疗或诊断复合物的组合物

    公开(公告)号：US09095613B2

    公开(公告)日：2015-08-04

    申请号：US12673122

    申请日：2009-10-28

    申请人： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

    发明人： Yong-Doo Choi ,  Bo-Seung Jang ,  Jin-Young Park ,  Jung-Im Lee ,  In-Hoo Kim

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K41/00 ,  A61K33/24 ,  A61K49/00

    CPC分类号： A61K41/0071 ,  A61K33/24 ,  A61K49/0036 ,  A61K49/0065 ,  Y10T428/2991

    摘要： Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.

    摘要翻译： 提供了一种光敏剂 - 金属纳米颗粒电荷复合物和用于光动力学治疗或诊断的组合物。 络合物包括金属纳米颗粒，带有第一电荷的光敏剂和与金属纳米颗粒结合的连接体，并且与第一电荷具有相反极性的第二电荷充电。 在血液循环过程中，光敏剂 - 金属纳米粒子电荷复合物保持复合型，从而可以降低光敏感副作用的持续时间。 在肿瘤组织中，复合物被特异地累积，但在正常组织中，复合物难以渗透。 因此，复合物可以选择性地破坏肿瘤组织。 此外，肿瘤组织中的选择性荧光可以使用复合物进一步提高诊断肿瘤的准确性。