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    Manipulation of fluids and reactions in microfluidic systems
    3.
    发明授权
    Manipulation of fluids and reactions in microfluidic systems 有权
    在微流体系统中操纵流体和反应

    公开(公告)号：US08772046B2

    公开(公告)日：2014-07-08

    申请号：US12525749

    申请日：2008-02-06

    申请人： Seth Fraden ,  Galder Cristobal-Azkarate

    发明人： Seth Fraden ,  Galder Cristobal-Azkarate

    IPC分类号： G01N1/38 ,  B01L3/00

    CPC分类号： B01L3/502784 ,  B01L3/06 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L7/54 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  G01N1/38 ,  G01N2001/386 ,  Y10T137/0318 ,  Y10T436/2575

    摘要： Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. In some embodiments, positioning of the droplets can take place in the order in which they are introduced into the microfluidic network (e.g., sequentially) without significant physical contact between the droplets. Because of the little or no contact between the droplets, there may be little or no coalescence between the droplets. Accordingly, in some such embodiments, surfactants are not required in either the fluid sample or the carrier fluid to prevent coalescence of the droplets. Structures and methods described herein also enable droplets to be removed sequentially from the predetermined regions.

    摘要翻译： 提供微流体结构和操纵流体和反应的方法。 这样的结构和方法可以涉及在微流体网络中的预定区域中将例如液​​滴形式的流体样品定位在载体流体（例如，可能与流体样品不混溶的油）中。 在一些实施例中，液滴的定位可以按照它们被引入微流体网络（例如，顺序地）而没有液滴之间的显着物理接触的顺序进行。 由于液滴之间很少或没有接触，所以液滴之间可能很少或没有聚结。 因此，在一些这样的实施方案中，在流体样品或载体流体中不需要表面活性剂以防止液滴的聚结。 本文所述的结构和方法还使得能够从预定区域顺序地去除液滴。

    MANIPULATION OF FLUIDS AND REACTIONS IN MICROFLUIDIC SYSTEMS
    4.
    发明申请
    MANIPULATION OF FLUIDS AND REACTIONS IN MICROFLUIDIC SYSTEMS 有权
    微流控系统中流体和反应的操作

    公开(公告)号：US20100163109A1

    公开(公告)日：2010-07-01

    申请号：US12525749

    申请日：2008-02-06

    申请人： Seth Fraden ,  Galder Cristobal-Azkarate

    发明人： Seth Fraden ,  Galder Cristobal-Azkarate

    IPC分类号： F17D1/00

    CPC分类号： B01L3/502784 ,  B01L3/06 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L7/54 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2400/0406 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  G01N1/38 ,  G01N2001/386 ,  Y10T137/0318 ,  Y10T436/2575

    摘要： Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. In some embodiments, positioning of the droplets can take place in the order in which they are introduced into the microfluidic network (e.g., sequentially) without significant physical contact between the droplets. Because of the little or no contact between the droplets, there may be little or no coalescence between the droplets. Accordingly, in some such embodiments, surfactants are not required in either the fluid sample or the carrier fluid to prevent coalescence of the droplets. Structures and methods described herein also enable droplets to be removed sequentially from the predetermined regions.

    摘要翻译： 提供微流体结构和操纵流体和反应的方法。 这样的结构和方法可以涉及在微流体网络中的预定区域中将例如液​​滴形式的流体样品定位在载体流体（例如，可能与流体样品不混溶的油）中。 在一些实施例中，液滴的定位可以按照它们被引入微流体网络（例如，顺序地）而没有液滴之间的显着物理接触的顺序进行。 由于液滴之间很少或没有接触，所以液滴之间可能很少或没有聚结。 因此，在一些这样的实施方案中，在流体样品或载体流体中不需要表面活性剂以防止液滴的聚结。 本文所述的结构和方法还使得能够从预定区域顺序地去除液滴。

    SYSTEMS AND METHODS FOR DETERMINING PROCESS CONDITIONS IN CONFINED VOLUMES
    8.
    发明申请
    SYSTEMS AND METHODS FOR DETERMINING PROCESS CONDITIONS IN CONFINED VOLUMES 审中-公开
    用于确定配制体积过程条件的系统和方法

    公开(公告)号：US20120190127A1

    公开(公告)日：2012-07-26

    申请号：US13377929

    申请日：2010-06-08

    申请人： Seth Fraden

    发明人： Seth Fraden

    IPC分类号： G01N1/28 ,  G01N23/20

    CPC分类号： B01D9/00 ,  B01D9/0077 ,  C07K1/306 ,  C30B7/00 ,  C30B29/58 ,  C30B35/00 ,  Y10T436/25

    摘要： Systems and methods for the determination of properties in confined (volumes are generally described. Generally, a gradient in at least one parameter (e.g., temperature) may be established across a plurality of confined volumes. In addition, at least one property (e.g., whether a crystal has been formed in the confined volume) of an interaction in at least one confined volume may be determined. In some embodiments, based upon the property determining step, a relationship between at least one parameter and at least one property may be determined. The confined volumes in which crystals may be contained may include, but are not limited to, droplets, microwells, and the like.

    摘要翻译： 通常可以在多个限定体积内建立至少一个参数（如温度）中的梯度，另外还有至少一个属性（例如， 在一些实施例中，基于属性确定步骤，可以确定至少一个参数与至少一个属性之间的关系，并且可以确定在至少一个限制体积中的相互作用的关系 可以含有晶体的限定体积可以包括但不限于液滴，微孔等。