摘要:
A compound of the formula ##STR1## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tettrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.
摘要:
The compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, amino, isonitrile or an organic residue bonded through nitrogen; R.sup.2 is carboxy or a group derivable therefrom; X is hydrogen, methoxy, formylamino, alkyl which may be substituted, alkylthio in which the sulfur atom may be oxidized or azido, or forms a double bond together with the adjacent carbon atom; provided that when R.sup.1 is acetylamino or amino and X is hydrogen, R.sup.2 is not para-nitrobenzyloxycarbonyl or benzhydryloxycarbonyl, or a pharmaceutically acceptable salt thereof, exhibit excellent antimicrobial activity, and are utilized as antimicrobial agents.
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.
摘要:
Novel antibiotics TAN-1057 represented by the formula: ##STR1## wherein, the absolute configuration at (A) is R or S; R.sub.1 is hydrogen and both R.sub.2 and R.sub.3 taken together form a chemical bond, or R.sub.3 is hydrogen and both R.sub.1 and R.sub.2 taken together form a chemical bond; were produced by microorganisms belonging to the genus Flexibacter. TAN-1057 strongly inhibit the growth of pathogenic microorganisms and malignant tumors, thus being useful as therapeutic agents of infectious diseases or antitumor agents.
摘要:
The iron-containing biologically active peptide TAN-866 produced by microorganisms belonging to the genus Pseudomonas and its iron free compounds have antibacterial activity mainly against gram-negative bacteria. These peptides can be used as a therepeutic agent for bacterial infections in mammals, domestic fowl, etc., caused by Pseudomonas aeruginosa. Further, TAN-866 and its deacyl compounds are also promising as the starting materials and intermediates for the synthesis of novel products.
摘要:
Antibiotic TAN-558 produced by a microorganism of the genus Empedobacter or genus Lysobacter, its p-nitrobenzyl- or benzhydryl ester derivative, or their N-deacetylated derivatives or salts thereof possess antimicrobial activities against Gram-positive and Gram-negative bacteria, and can be used as a therapeutic agent for bacterial infections in mammals, fowls, etc.
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 stands for hydrogen, alanyl or alanyl-alanyl, or its salt, which can be produced by cultivating a microorganism belonging to the genus Lysobacter, is useful as a therapeutic agent against infectious disease caused by bacteria.
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 is ##STR2## HOOC--(CH.sub.2).sub.3 --CO-- or hydrogen, or a salt thereof, is useful as an intermediate for the production of cephem compounds, and some of them are useful as antimicrobial agents.
摘要:
Disclosed is a data communication apparatus for non-contact data communication using electromagnetic induction. At least a portion of a conductor 5a of the loop coil antenna (5) of the data communication apparatus, adapted for non-contact data communication, exploiting electromagnetic induction, is arranged for extending along the lateral side of an enclosure (2a) for equalizing the sensitivity of the loop coil antenna (5) across both major surfaces of the enclosure (2a).
摘要:
A compound of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or aliphatic acyl, A is amino which may be protected, X is an amino acid sequence consisting of 1 to 10 amino acid residues which contain at least one amino acid residue having a water-solubility enhancing group, or a salt thereof has an activity of remarkably improving hematopoietic disorder and is useful as an immuno-stimulating agent or an agent for treating thrombocytopenia.