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21 条记录 (耗时 0.024 秒)

    Antibiotic tan-749, its derivatives, production and use thereof
    2.
    发明授权
    Antibiotic tan-749, its derivatives, production and use thereof 失效
    抗生素tan-749，其衍生物，生产和使用

    公开(公告)号：US4906659A

    公开(公告)日：1990-03-06

    申请号：US129737

    申请日：1987-12-07

    申请人： Setsuo Harada ,  Hideo Ono ,  Hirotomo Masuya ,  Hideaki Natsugari

    发明人： Setsuo Harada ,  Hideo Ono ,  Hirotomo Masuya ,  Hideaki Natsugari

    IPC分类号： C07C237/22 ,  C07C255/29 ,  C07C257/14 ,  C07D295/13 ,  C07C123/00 ,  A61K35/00

    CPC分类号： C07D295/13 ,  C07C237/22 ,  C07C255/29 ,  C07C257/14 ,  C07C2101/02 ,  Y02P20/55

    摘要： A compound of the formula ##STR1## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tettrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.

    摘要翻译： 式IMA的化合物，其中R 1和R 4独立地为氨基或通过氮键合的有机残基，R 2为氢或可被取代的烷基，R 3为氢或保护基，R 5为可被取代的羟基或氨基 其可以被取代或其盐; 条件是当R1为氨基，亮氨酰氨基，乙酰氨基或苄氧羰基氨基时，R3为氢，甲基或2-四氢吡喃基，R4为氨基，乙酰氨基或苄氧羰基氨基，R5为可被取代的羟基或可被取代的氨基，R2为烷基 其可以被取代，对耐药细菌具有抗菌活性，因此可用作哺乳动物细菌感染的化学治疗药物。

    Cephem compounds and their production
    4.
    发明授权
    Cephem compounds and their production 失效
    头孢烯化合物及其生产

    公开(公告)号：US4667027A

    公开(公告)日：1987-05-19

    申请号：US681783

    申请日：1984-12-14

    申请人： Setsuo Harada ,  Yukimasa Nozaki ,  Hideo Ono

    发明人： Setsuo Harada ,  Yukimasa Nozaki ,  Hideo Ono

    IPC分类号： C07D501/28 ,  C07D501/57 ,  C12P35/06 ,  C12P35/08 ,  A61K31/545 ,  C07D501/40

    CPC分类号： C12P35/06 ,  C12P35/08

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.

    摘要翻译： 下式的化合物：其中R1代表氢或甲酰氨基，R2是选自丝氨酸和丙氨酸的氨基酸残基，或这些氨基酸中的至少一个的肽或氢，R3 代表通过培养属于黄单胞菌属的微生物产生的-NH-C（= NH）-NH 2或-CH 2 NH 2或其盐可用作抗细菌感染性疾病的治疗剂。

    Antibiotics, their production and use
    6.
    发明授权
    Antibiotics, their production and use 失效
    抗生素，其生产和使用

    公开(公告)号：US4656288A

    公开(公告)日：1987-04-07

    申请号：US714084

    申请日：1985-03-20

    申请人： Hideo Ono ,  Yukimasa Nozaki ,  Setsuo Harada

    发明人： Hideo Ono ,  Yukimasa Nozaki ,  Setsuo Harada

    IPC分类号： C12P1/04 ,  C07D261/02 ,  A61K31/42

    CPC分类号： C12P1/04

    摘要： Antibiotic TAN-558 produced by a microorganism of the genus Empedobacter or genus Lysobacter, its p-nitrobenzyl- or benzhydryl ester derivative, or their N-deacetylated derivatives or salts thereof possess antimicrobial activities against Gram-positive and Gram-negative bacteria, and can be used as a therapeutic agent for bacterial infections in mammals, fowls, etc.

    摘要翻译： 抗生素TAN-558由霉菌属或溶血杆菌属的微生物，其对硝基苄基 - 或二苯甲基酯衍生物或其N-脱乙酰基化衍生物或其盐具有抗革兰氏阳性和革兰氏阴性菌的抗微生物活性，并且可以 用作哺乳动物，家禽等细菌感染的治疗剂

    Friction engagement device
    10.
    发明申请
    Friction engagement device 有权
    摩擦接合装置

    公开(公告)号：US20070199789A1

    公开(公告)日：2007-08-30

    申请号：US11703793

    申请日：2007-02-08

    申请人： Masaaki Nishida ,  Satoru Kasuya ,  Masashi Kito ,  Yoshihisa Yamamoto ,  Akitomo Suzuki ,  Masato Fujikawa ,  Ryuji Ibaraki ,  Masatoshi Adachi ,  Tsuyoshi Mikami ,  Hideo Ono

    发明人： Masaaki Nishida ,  Satoru Kasuya ,  Masashi Kito ,  Yoshihisa Yamamoto ,  Akitomo Suzuki ,  Masato Fujikawa ,  Ryuji Ibaraki ,  Masatoshi Adachi ,  Tsuyoshi Mikami ,  Hideo Ono

    IPC分类号： F16D13/72

    CPC分类号： F16D25/123 ,  F16D13/683 ,  F16D13/74 ,  F16D2300/06 ,  F16H57/0482

    摘要： Lubricating oil supply holes are drilled into a first member that is fitted to a plurality of first annular plates by a spline. Of splines to which each lubricating oil supply hole corresponds, lubricating oil grooves provided in the plurality of first annular plates do not overlap the splines on at least one of the front and rear surfaces of the first annular plates, and therefore lubricating oil flowing out of the lubricating oil supply holes is dispersed in a circumferential direction and flows from the inner periphery to the outer periphery of the first annular plates, rather than gathering in each lubricating oil groove and flowing in an outer peripheral direction. As a result, a force generated by an axial lubricating oil flow, which acts in a direction for causing the second annular plates to contact friction materials on the first annular plates, is suppressed, leading to a reduction in drag torque.

    摘要翻译： 润滑油供给孔被钻入通过花键装配到多个第一环形板的第一构件。 每个润滑油供应孔对应的花键，设置在多个第一环形板中的润滑油槽不与第一环形板的前表面和后表面中的至少一个上的花键重叠，因此润滑油从 润滑油供给孔沿圆周方向分散，从第一环状板的内周向外周流动，而不是聚集在各润滑油槽内并沿外周方向流动。 结果，抑制了由使第二环状板与第一环状板上的摩擦材料接触的方向起作用的轴向润滑油流产生的力，导致拖曳转矩的降低。