摘要:
A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.
摘要:
Antibiotic TAN-558 produced by a microorganism of the genus Empedobacter or genus Lysobacter, its p-nitrobenzyl- or benzhydryl ester derivative, or their N-deacetylated derivatives or salts thereof possess antimicrobial activities against Gram-positive and Gram-negative bacteria, and can be used as a therapeutic agent for bacterial infections in mammals, fowls, etc.
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 stands for hydrogen, alanyl or alanyl-alanyl, or its salt, which can be produced by cultivating a microorganism belonging to the genus Lysobacter, is useful as a therapeutic agent against infectious disease caused by bacteria.
摘要:
A compound of the formula ##STR1## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tettrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 is ##STR2## HOOC--(CH.sub.2).sub.3 --CO-- or hydrogen, or a salt thereof, is useful as an intermediate for the production of cephem compounds, and some of them are useful as antimicrobial agents.
摘要:
Novel antibiotics TAN-1057 represented by the formula: ##STR1## wherein, the absolute configuration at (A) is R or S; R.sub.1 is hydrogen and both R.sub.2 and R.sub.3 taken together form a chemical bond, or R.sub.3 is hydrogen and both R.sub.1 and R.sub.2 taken together form a chemical bond; were produced by microorganisms belonging to the genus Flexibacter. TAN-1057 strongly inhibit the growth of pathogenic microorganisms and malignant tumors, thus being useful as therapeutic agents of infectious diseases or antitumor agents.
摘要:
The iron-containing biologically active peptide TAN-866 produced by microorganisms belonging to the genus Pseudomonas and its iron free compounds have antibacterial activity mainly against gram-negative bacteria. These peptides can be used as a therepeutic agent for bacterial infections in mammals, domestic fowl, etc., caused by Pseudomonas aeruginosa. Further, TAN-866 and its deacyl compounds are also promising as the starting materials and intermediates for the synthesis of novel products.
摘要:
For cutting sheet metal or other work by means of a jet of water containing abrasive particles, an abrasive water jet nozzle assembly is provided to which there are separately supplied highly pressurized water and an abrasive suspension. The abrasive suspension is such that abrasive particles with an average size of up to 100 microns are held in suspension in water. The abrasive suspension is introduced into the ejected water by virtue of a partial vacuum created in the nozzle assembly by the pressurized water. The nozzle assembly directs the resulting mixture as an abrasive water jet against the work for cutting thereof. Preferably, the abrasive water jet is recovered for recirculation back to the nozzle assembly as an abrasive suspension of controlled abrasive concentration. Various constructions of the nozzle assembly and various recovery systems are also disclosed.
摘要:
A crack-type fatigue detecting sensor comprises: a foil substrate having a first surface and a second surface fixed to a member to be tested; and a foil fracture piece having a slit formed in a central portion between opposite end portions in a longitudinal direction thereof such that the slit extends from one side portion toward the other side portion in a width direction thereof perpendicular to the longitudinal direction, wherein the opposite end portions of the fracture piece are respectively fixed to the first surface of the substrate and a portion including the central portion having the slit has a thickness smaller than a thickness of the opposite end portions over a whole width.
摘要:
Lubricating oil supply holes are drilled into a first member that is fitted to a plurality of first annular plates by a spline. Of splines to which each lubricating oil supply hole corresponds, lubricating oil grooves provided in the plurality of first annular plates do not overlap the splines on at least one of the front and rear surfaces of the first annular plates, and therefore lubricating oil flowing out of the lubricating oil supply holes is dispersed in a circumferential direction and flows from the inner periphery to the outer periphery of the first annular plates, rather than gathering in each lubricating oil groove and flowing in an outer peripheral direction. As a result, a force generated by an axial lubricating oil flow, which acts in a direction for causing the second annular plates to contact friction materials on the first annular plates, is suppressed, leading to a reduction in drag torque.