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31 条记录 (耗时 0.024 秒)

    Isomerization of .beta.-lactam compounds
    4.
    发明授权
    Isomerization of .beta.-lactam compounds 失效
    β-内酰胺化合物异构化

    公开(公告)号：US4497742A

    公开(公告)日：1985-02-05

    申请号：US351927

    申请日：1982-02-24

    申请人： Setsuo Harada ,  Shigetoshi Tsubotani ,  Mitsuko Asai

    发明人： Setsuo Harada ,  Shigetoshi Tsubotani ,  Mitsuko Asai

    IPC分类号： C07D477/20 ,  C12P17/18 ,  C07D487/04 ,  A61K31/40

    CPC分类号： C07D477/20 ,  C12P17/184

    摘要： Compounds of the formula (I): ##STR1## wherein R is an ethyl group which may optionally be substituted and n is 0 or 1, or a physiologically acceptable salt thereof, can be produced by subjecting to isomerization a compound of the formula (II): ##STR2## wherein R and n have the same meaning as defined above, or a salt thereof, by using a quaternary ammonium halide and are useful as a bactericide or disinfectant, and also a synergistic effect with penicillin and/or cephalosporin antibiotic agents.Among the compounds of the formula (I), compounds shown by the formula: ##STR3## wherein R.sub.6 is H or --SO.sub.3 H, as well as salts thereof, are novel.

    摘要翻译： 式（I）化合物：其中R是可任意取代的乙基，n为0或1的化合物或其生理学上可接受的盐可以通过将 式（II）：其中R和n具有与上述相同的含义，或其盐，通过使用季铵卤化物，并且可用作杀菌剂或消毒剂，以及与青霉素的协同效应 和/或头孢菌素抗生素。 在式（I）的化合物中，由下式表示的化合物：其中R6是H或-SO3H，以及其盐是新颖的。

    Cephem compounds and their production
    5.
    发明授权
    Cephem compounds and their production 失效
    头孢烯化合物及其生产

    公开(公告)号：US4667027A

    公开(公告)日：1987-05-19

    申请号：US681783

    申请日：1984-12-14

    申请人： Setsuo Harada ,  Yukimasa Nozaki ,  Hideo Ono

    发明人： Setsuo Harada ,  Yukimasa Nozaki ,  Hideo Ono

    IPC分类号： C07D501/28 ,  C07D501/57 ,  C12P35/06 ,  C12P35/08 ,  A61K31/545 ,  C07D501/40

    CPC分类号： C12P35/06 ,  C12P35/08

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.

    摘要翻译： 下式的化合物：其中R1代表氢或甲酰氨基，R2是选自丝氨酸和丙氨酸的氨基酸残基，或这些氨基酸中的至少一个的肽或氢，R3 代表通过培养属于黄单胞菌属的微生物产生的-NH-C（= NH）-NH 2或-CH 2 NH 2或其盐可用作抗细菌感染性疾病的治疗剂。

    Antibiotics, their production and use
    8.
    发明授权
    Antibiotics, their production and use 失效
    抗生素，其生产和使用

    公开(公告)号：US4656288A

    公开(公告)日：1987-04-07

    申请号：US714084

    申请日：1985-03-20

    申请人： Hideo Ono ,  Yukimasa Nozaki ,  Setsuo Harada

    发明人： Hideo Ono ,  Yukimasa Nozaki ,  Setsuo Harada

    IPC分类号： C12P1/04 ,  C07D261/02 ,  A61K31/42

    CPC分类号： C12P1/04

    摘要： Antibiotic TAN-558 produced by a microorganism of the genus Empedobacter or genus Lysobacter, its p-nitrobenzyl- or benzhydryl ester derivative, or their N-deacetylated derivatives or salts thereof possess antimicrobial activities against Gram-positive and Gram-negative bacteria, and can be used as a therapeutic agent for bacterial infections in mammals, fowls, etc.

    摘要翻译： 抗生素TAN-558由霉菌属或溶血杆菌属的微生物，其对硝基苄基 - 或二苯甲基酯衍生物或其N-脱乙酰基化衍生物或其盐具有抗革兰氏阳性和革兰氏阴性菌的抗微生物活性，并且可以 用作哺乳动物，家禽等细菌感染的治疗剂

    Antibiotic tan-749, its derivatives, production and use thereof
    10.
    发明授权
    Antibiotic tan-749, its derivatives, production and use thereof 失效
    抗生素tan-749，其衍生物，生产和使用

    公开(公告)号：US4906659A

    公开(公告)日：1990-03-06

    申请号：US129737

    申请日：1987-12-07

    申请人： Setsuo Harada ,  Hideo Ono ,  Hirotomo Masuya ,  Hideaki Natsugari

    发明人： Setsuo Harada ,  Hideo Ono ,  Hirotomo Masuya ,  Hideaki Natsugari

    IPC分类号： C07C237/22 ,  C07C255/29 ,  C07C257/14 ,  C07D295/13 ,  C07C123/00 ,  A61K35/00

    CPC分类号： C07D295/13 ,  C07C237/22 ,  C07C255/29 ,  C07C257/14 ,  C07C2101/02 ,  Y02P20/55

    摘要： A compound of the formula ##STR1## wherein R.sup.1 and R.sup.4 are independently amino or an organic residue bonded through nitrogen, R.sup.2 is hydrogen or alkyl which may be substituted, R.sup.3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R.sup.1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R.sup.3 is hydrogen, methyl or 2-tettrahydropyranyl, R.sup.4 is amino, acetylamino or benzyloxycarbonylamino and R.sup.5 is hydroxyl which may be substituted or amino which may be substituted, R.sup.2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.

    摘要翻译： 式IMA的化合物，其中R 1和R 4独立地为氨基或通过氮键合的有机残基，R 2为氢或可被取代的烷基，R 3为氢或保护基，R 5为可被取代的羟基或氨基 其可以被取代或其盐; 条件是当R1为氨基，亮氨酰氨基，乙酰氨基或苄氧羰基氨基时，R3为氢，甲基或2-四氢吡喃基，R4为氨基，乙酰氨基或苄氧羰基氨基，R5为可被取代的羟基或可被取代的氨基，R2为烷基 其可以被取代，对耐药细菌具有抗菌活性，因此可用作哺乳动物细菌感染的化学治疗药物。